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Innate Discovery Team

Innate Discovery Team
先天探索团队
批准号：
8294657
负责人：
Nina Bhardwaj
金额：
$120.4万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-07-01 至 2013-06-30
来源：
https://reporter.nih.gov/project-details/8294657
关键词：
AIDS/HIV problemActivities of Daily LivingAcuteHIV InfectionsImmunologyIn VitroIndividualInfectionPeripheral Blood Mononuclear CellPhasePropertyRelative (related person)Resistance to infectionVaccinesinnate immune functioninsightperipheral blood

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英文摘要
1. Specific aims The specific aims of the entire innate expansion project are: 1. To characterise the functional capacity of peripheral blood NK and DC subsets during the earliest phase of acute HIV infection (AMI), to gain insight into innate immune functions in the critical initial phase of infection, ii. To analyse the functional properties of peripheral blood NK and DC subsets in EU and UU individuals, to identify protective aspects of the functions/interaction of innate subsets associated with EU status. iii. To compare the capacity of peripheral blood mononuclear cells (PBMCs) from EU and UU individuals to support HIV infection in vitro, and investigate the mechanisms underlying relative resistance to infection.
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The Tisch Cancer Institute (TCI) Paul Calabresi K12 Career Development Award for Clinical Oncology
Dissecting myeloid cell-mediated resistance to immune checkpoint blockade in bladder cancer
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