Establishing the Relationship Between Muscle Quality and Joint Loading for Individuals with Transtibial Amputation
建立小腿截肢患者的肌肉质量和关节负荷之间的关系
基本信息
- 批准号:10677236
- 负责人:
- 金额:$ 6.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-24 至 2026-04-23
- 项目状态:未结题
- 来源:
- 关键词:Activities of Daily LivingAffectAmputationAnisotropyAwardBiomechanicsBiomedical EngineeringClinical ResearchCollaborationsComputer ModelsDataDegenerative polyarthritisDevelopmentDevicesDiffusion Magnetic Resonance ImagingEducational workshopEnvironmentEvaluationEventFellowshipFiberFibrosisFoundationsFunctional disorderFutureGaitGoalsGrantHealthImageImaging TechniquesIndividualInfiltrationInjuryInstitutionInterventionIsometric ExerciseJointsKineticsKneeKnee jointLengthLifeLimb structureLower ExtremityMagnetic Resonance ImagingMapsMeasuresMechanicsMedical ImagingMentorsMentorshipModelingMorphologyMotionMovementMuscleMuscle FibersMuscle functionMusculoskeletalNational Research Service AwardsOrthopedicsOutcomeParticipantPatient Self-ReportPostdoctoral FellowPropertyQuality of lifeRelaxationResearch PersonnelRiskScientistSideStatistical Data InterpretationSurveysTechnical ExpertiseTechniquesTestingThigh structureTimeTissuesTrainingUnited StatesWalkingWorkWritingcareercareer developmentclinically relevantdesignfunctional improvementfunctional outcomesimage processingimprovedinsightinstrumentjoint loadingkinematicslimb amputationlimb losslong-term sequelaeloss of functionmuscle strengthnovelnovel imaging techniquenovel therapeutic interventionprosthesis wearerprosthetic socketquadriceps muscleresearch data disseminationresidual limbskill acquisitionskillsstatisticssuccesstranslational scientist
项目摘要
ABSTRACT
The loss of function following an amputation is profound and life altering. To date, interventions to improve long
term functional abilities and limit detrimental secondary injuries (e.g. osteoarthritis) have not been effective.
While multifactorial, the effect of altered muscle quality, specifically of the quadriceps, on functional outcomes
for individuals with transtibial amputation is poorly understood. Work by our group in other conditions shows
that muscle quality changes after injury and is directly related to loss of function, including protracted strength
deficits. My long-term career goal is to combine my background in bioengineering with the skills developed
through this F32 training grant to develop novel therapeutic strategies and devices to improve function and
quality of life for individuals with lower limb loss. This training award will allow me to 1) assess the muscle
quality of the thigh of the intact and residual limbs with novel magnetic resonance imaging sequences, 2)
predict the relationship between thigh muscle quality and muscle strength, and finally 3) characterize the
relationship between muscle quality, muscle strength, and knee joint loading for individuals with transtibial
amputation. Muscle quality will be assessed using novel magnetic resonance imaging techniques including
T1rho mapping and diffusion tensor imaging. These techniques will provide new insights on the muscle tissue
morphology, including any increases in fibrotic tissue or decreases in pennation angle and fiber tract length,
that affect the muscle's overall ability to function properly and efficiently. To evaluate muscle strength and
mobility, participants will complete maximum voluntary isometric knee flexion and validated surveys targeting
self-reported mobility. Finally, joint contact forces of the intact limb will be assessed through a computational
musculoskeletal model. Through the work proposed for this NRSA F32, I will refine and gain skills critical for a
successful career as an independent translational researcher seeking to collaborate with clinician scientists.
Training will include skills development in medical imaging acquisition and analysis, clinically relevant strength
assessment, instrumented motion analysis, musculoskeletal modeling, clinical research management, and
statistical analysis. Including in the training plan are accessory career development activities including related
course work (e.g. biomechanics, statistics, medical imaging), grant writing workshops, opportunities for
research dissemination, and mentorship that will all be key components to developing a well-rounded skill set
for a future academic career. My selected sponsor, institution, and mentors will provide the perfect
environment for encouraging success.
抽象的
截肢后的功能丧失是深远的,并且会改变生活。迄今为止,改善长期的干预措施
长期功能能力和限制有害的继发性损伤(例如骨关节炎)效果不佳。
虽然是多因素的,但肌肉质量改变(特别是股四头肌)对功能结果的影响
对于经过胫骨截肢的人来说,人们知之甚少。我们小组在其他条件下的工作表明
肌肉质量在受伤后发生变化,与功能丧失直接相关,包括持久的力量
赤字。我的长期职业目标是将我的生物工程背景与所开发的技能结合起来
通过这项 F32 培训补助金来开发新的治疗策略和设备,以改善功能和
下肢丧失患者的生活质量。该训练奖将使我能够 1) 评估肌肉
使用新型磁共振成像序列评估完整肢体和残肢的大腿质量,2)
预测大腿肌肉质量和肌肉力量之间的关系,最后3)表征
跨胫骨患者的肌肉质量、肌肉力量和膝关节负荷之间的关系
截肢。将使用新型磁共振成像技术评估肌肉质量,包括
T1rho 映射和扩散张量成像。这些技术将为肌肉组织提供新的见解
形态学,包括纤维化组织的任何增加或羽状角和纤维束长度的减少,
影响肌肉正常有效运作的整体能力。评估肌肉力量和
活动性,参与者将完成最大限度的自愿等长膝关节屈曲和针对目标的经过验证的调查
自我报告的流动性。最后,完整肢体的关节接触力将通过计算进行评估
肌肉骨骼模型。通过为 NRSA F32 提出的工作,我将完善并获得对 NRSA F32 至关重要的技能
作为一名独立转化研究人员,寻求与临床科学家合作,取得了成功的职业生涯。
培训将包括医学成像采集和分析方面的技能发展、临床相关实力
评估、仪器化运动分析、肌肉骨骼建模、临床研究管理,以及
统计分析。培训计划中包括辅助职业发展活动,包括相关的
课程作业(例如生物力学、统计学、医学成像)、资助写作研讨会、
研究传播和指导都是发展全面技能的关键组成部分
为了未来的学术生涯。我选择的赞助商、机构和导师将提供完美的
鼓励成功的环境。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Meredith Owen其他文献
Meredith Owen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 6.91万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 6.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 6.91万 - 项目类别:
Studentship














{{item.name}}会员




