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Establishing the Relationship Between Muscle Quality and Joint Loading for Individuals with Transtibial Amputation

建立小腿截肢患者的肌肉质量和关节负荷之间的关系

基本信息

批准号：
10677236
负责人：
Meredith Owen
金额：
$ 6.91万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-24 至 2026-04-23
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10677236
关键词：
Activities of Daily Living Affect Amputation Anisotropy Award Biomechanics Biomedical Engineering Clinical Research Collaborations Computer Models Data Degenerative polyarthritis Development Devices Diffusion Magnetic Resonance Imaging Educational workshop Environment Evaluation Event Fellowship Fiber Fibrosis Foundations Functional disorder Future Gait Goals Grant Health Image Imaging Techniques Individual Infiltration Injury Institution Intervention Isometric Exercise Joints Kinetics Knee Knee joint Length Life Limb structure Lower Extremity Magnetic Resonance Imaging Maps Measures Mechanics Medical Imaging Mentors Mentorship Modeling Morphology Motion Movement Muscle Muscle Fibers Muscle function Musculoskeletal National Research Service Awards Orthopedics Outcome Participant Patient Self-Report Postdoctoral Fellow Property Quality of life Relaxation Research Personnel Risk Scientist Side Statistical Data Interpretation Surveys Technical Expertise Techniques Testing Thigh structure Time Tissues Training United States Walking Work Writing career career development clinically relevant design functional improvement functional outcomes image processing improved insight instrument joint loading kinematics limb amputation limb loss long-term sequelae loss of function muscle strength novel novel imaging technique novel therapeutic intervention prosthesis wearer prosthetic socket quadriceps muscle research data dissemination residual limb skill acquisition skills statistics success translational scientist

项目摘要

ABSTRACT The loss of function following an amputation is profound and life altering. To date, interventions to improve long term functional abilities and limit detrimental secondary injuries (e.g. osteoarthritis) have not been effective. While multifactorial, the effect of altered muscle quality, specifically of the quadriceps, on functional outcomes for individuals with transtibial amputation is poorly understood. Work by our group in other conditions shows that muscle quality changes after injury and is directly related to loss of function, including protracted strength deficits. My long-term career goal is to combine my background in bioengineering with the skills developed through this F32 training grant to develop novel therapeutic strategies and devices to improve function and quality of life for individuals with lower limb loss. This training award will allow me to 1) assess the muscle quality of the thigh of the intact and residual limbs with novel magnetic resonance imaging sequences, 2) predict the relationship between thigh muscle quality and muscle strength, and finally 3) characterize the relationship between muscle quality, muscle strength, and knee joint loading for individuals with transtibial amputation. Muscle quality will be assessed using novel magnetic resonance imaging techniques including T1rho mapping and diffusion tensor imaging. These techniques will provide new insights on the muscle tissue morphology, including any increases in fibrotic tissue or decreases in pennation angle and fiber tract length, that affect the muscle's overall ability to function properly and efficiently. To evaluate muscle strength and mobility, participants will complete maximum voluntary isometric knee flexion and validated surveys targeting self-reported mobility. Finally, joint contact forces of the intact limb will be assessed through a computational musculoskeletal model. Through the work proposed for this NRSA F32, I will refine and gain skills critical for a successful career as an independent translational researcher seeking to collaborate with clinician scientists. Training will include skills development in medical imaging acquisition and analysis, clinically relevant strength assessment, instrumented motion analysis, musculoskeletal modeling, clinical research management, and statistical analysis. Including in the training plan are accessory career development activities including related course work (e.g. biomechanics, statistics, medical imaging), grant writing workshops, opportunities for research dissemination, and mentorship that will all be key components to developing a well-rounded skill set for a future academic career. My selected sponsor, institution, and mentors will provide the perfect environment for encouraging success.

摘要