Targeting the hepatic adropin signaling pathway in obesity
靶向肥胖中的肝脏 adropin 信号通路
基本信息
- 批准号:10677279
- 负责人:
- 金额:$ 4.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimal ModelApoptosisAtherosclerosisBiochemicalBioenergeticsBiological ProcessBrainCardiacCell membraneCellsComplexCoronary ArteriosclerosisDefectDevelopmentDiabetes MellitusDietDiseaseDisease ProgressionEducationEndotheliumEnergy Metabolism PathwayEnzymesEssential GenesExhibitsFatty AcidsFatty LiverFatty acid glycerol estersFellowshipFibrosisG-Protein-Coupled ReceptorsGenetic DiseasesGlucoseGoalsHeartHepaticHepatocyteHistologicHomeostasisImmunohistochemistryImpairmentIn VitroInflammationInflammatory ResponseKnock-outKnockout MiceLigandsLinkLipidsLiverMeasuresMediatingMediatorMetabolicMetabolic DiseasesMetabolismMolecularNull LymphocytesNutrientNutrition DisordersObesityObesity associated diseaseObesity associated liver diseaseOrphanPPAR gammaPathologicPathologyPeripheralPhenotypePopulationPrevalenceRecombinantsRegulationRegulatory PathwayResearchResistanceRisk FactorsRoleSignal PathwaySignal TransductionTechniquesTestingTherapeutic EffectTissuesTrainingUnited StatesUp-RegulationWestern BlottingWild Type Mouseblood glucose regulationcareerdesigndiabeticeffective therapyhuman subjectin vivolipid metabolismliver developmentliver injurymouse modelnon-alcoholic fatty liver diseasenonalcoholic steatohepatitisnoveloxidationoxidative damagepeptide hormonepreventable deathprotective effectreceptorresponseuptake
项目摘要
PROJECT SUMMARY/ABSTRACT
Obesity is the second leading cause of preventable death in the United States. Obesity is a complex nutritional
and genetic disorder that is driven by energy imbalances, and serves as a fundamental risk factor in various
pathologies including coronary artery disease, diabetes, non-alcoholic fatty liver disease, and atherosclerosis.
The cellular and molecular mechanisms that drive obesity-related disease in different tissues are not fully
elucidated, and this represents an impediment to the development of effective and efficient treatments. Adropin
is a recently characterized liver- and brain-derived peptide hormone that exerts powerful effects on fuel
substrate metabolism in peripheral tissues. Adropin levels are significantly reduced in obese and diabetic
human subjects, and this decrease is linked to increased adiposity and impaired glucose homeostasis.
Furthermore, adropin depletion has been linked with the development of liver-associated obesity diseases
such as NAFLD and NASH. In this fellowship application, we will determine the molecular signaling pathways
underlying adropin function in liver fuel metabolism, and investigate its protective effects against NAFLD and
NASH. In Aim 1, we will determine how adropin associates with the cell membrane receptor GPR19 to regulate
hepatocyte fuel metabolism. In Aim 2, we will determine if GPR19 is necessary for the protective effects of
adropin against hepatic injury. By combining cutting-edge metabolic techniques and a comprehensive training
plan, this fellowship will allow me to prepare for the next stage of my career in metabolic research and scientific
education.
项目摘要/摘要
在美国,肥胖是可预防死亡的第二大原因。肥胖是一种复杂的营养问题
以及由能量不平衡驱动的遗传性疾病,是各种疾病的基本风险因素
病理包括冠状动脉疾病、糖尿病、非酒精性脂肪性肝病和动脉粥样硬化。
在不同组织中导致肥胖相关疾病的细胞和分子机制还不完全清楚。
这对开发有效和高效的治疗方法构成了障碍。阿洛平
是一种新近鉴定的肝脏和大脑衍生的多肽激素,对燃料有强大的作用
外周组织中的底物代谢。肥胖症和糖尿病患者肾上腺素水平显著降低
这种下降与肥胖增加和葡萄糖稳态受损有关。
此外,肾上腺素缺乏与肝脏肥胖症的发生有关。
例如NAFLD和NASH。在这个团契申请中,我们将确定分子信号通路
了解肾上腺素在肝脏燃料代谢中的作用,并探讨其对NAFLD和
纳什。在目标1中,我们将确定肾上腺素如何与细胞膜受体GPR19结合来调节
肝细胞燃料代谢。在目标2中,我们将确定GPR19是否为保护作用所必需的
阿屈平抗肝损伤。通过结合尖端的新陈代谢技术和全面的培训
计划,这笔奖学金将使我为代谢研究和科学研究的下一阶段做准备
教育。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Bellina Mushala其他文献
Bellina Mushala的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 4.32万 - 项目类别:
Grant-in-Aid for Early-Career Scientists














{{item.name}}会员




