University of Arizona Cancer Center - Cancer Center Support Grant

总体：摘要 亚利桑那大学癌症中心(UACC)是唯一一个由国家癌症研究所(NCI)指定的 癌症中心总部设在亚利桑那州。UACC成立于45年前，已经 曾在亚利桑那大学、汇水区和 亚利桑那州。UACC的愿景是成为克服癌症风险、改进治疗方法的全国领导者， 培训有才华的科学家和供应商，并通过共同的决心让社区参与进来 发现、创新和消除社会不平等现象。这一愿景是通过UACC的使命实现的，即 减轻五县集水区内外癌症患者和家庭的负担 通过：(1)通过跨学科协作和团队科学探索科学发现；(2) 在患者的癌症之旅中增加获得最新方法的机会；(3)为几代人的 研究人员和卫生专业人员每天都在与癌症和影响弱势群体的不平等作斗争 以及(4)提供国家领导，以尊重、一致和 共同的信念。Joann Sweasy博士于2020年被任命为UACC主任，并促进了参与 癌症中心领导和成员围绕着这一使命和愿景。Sweasy启动了一项强有力的战略 导致制定2020-2025年战略计划的规划过程--“战胜癌症”， 强调围绕三个高度相关的中心范围的科学主题进行跨学科合作 到UACC的集水区：癌症与环境；癌症成像与生物工程；以及 治疗学和预防性干预。UACC吸引了来自11所大学和36所大学的151名成员 各部门。总资金为3380万美元(DC)，其中包括2610万美元的同行审查资金，其中1160万美元 (44%)来自NCI，1300万美元(50%)来自其他国家卫生研究院机构。这代表着一个几乎 与上一个项目期相比，同行审查的资金增加了20%。值得注意的是，UACC已经收到了 在此期间，NCI补充剂价值270万美元。2020年，2835名患者参加了介入试验，a 与2016年相比，应计项目增加了300%或3倍以上。在项目期间，办公室 启动了社区外联和参与活动，并启动了人口健康评估，以 更深入地描述集水区；癌症研究培训和教育协调办公室是 还成立了整合和扩大癌症管道计划和初级研究员指导的机构。在……下面 Sweasy的方向、研究计划和共享资源也进行了审查和重组 影响更大；扩大了内部筹资机会和创新工作组，以促进 跨学科协作和协调；在新的基础上启动了多年征聘工作 战略计划；实施了严格的方法以确保指标与癌症的相关性；以及 与Banner Health-Tucson形成了前所未有的合作，以促进临床研究和护理。

OVERALL: ABSTRACT The University of Arizona Cancer Center (UACC) is the only National Cancer Institute (NCI)-designated Cancer Center headquartered in the state of Arizona. UACC was established over 45 years ago and has served as the driver of cancer research at the University of Arizona, within the Catchment Area, and in the state of Arizona. UACC’s vision is to be a national leader for overcoming cancer risks, improving treatments, training talented scientists and providers, and engaging communities though a shared determination to discover, innovate, and remove social inequities. This vision is realized through UACC’s mission, which is to alleviate the burden of cancer on patients and families within a five-county Catchment Area and beyond through: (1) a quest for scientific discovery through interdisciplinary collaboration and team science; (2) increasing access to the latest approaches throughout a patient’s cancer journey; (3) preparing generations of researchers and health professionals to fight each day against cancer and the inequities affecting vulnerable populations; and (4) providing national leadership in engaging populations with respect, consistency, and shared conviction. Joann Sweasy, PhD, was appointed UACC Director in 2020 and has promoted engagement of cancer center leaders and members around this mission and vision. Sweasy initiated a robust strategic planning process that led to development of the 2020–2025 Strategic Plan, “Bear Down on Cancer”, emphasizing transdisciplinary collaboration around three Center-wide scientific themes that are highly relevant to UACC’s Catchment Area: Cancer and the Environment; Cancer Imaging and Bioengineering; and Novel Therapeutics and Preventive Interventions. UACC draws its 151 members from 11 colleges and 36 departments. Total funding is $33.8M (DC), which includes $26.1M in peer-reviewed funding of which $11.6M (44%) is from NCI and $13M (50%) from other National Institutes of Health agencies. This represents a nearly 20% increase in peer-reviewed funding compared to the prior project period. Of note, UACC has received $2.7M in NCI supplements during this period. In 2020, 2,835 patients were accrued to interventional trials, a more than 300% or 3-fold increase in accruals compared to 2016. During the project period, the Office of Community Outreach & Engagement was launched, and a population health assessment was initiated to profile the Catchment Area more deeply; an Office of Cancer Research Training & Education Coordination was also established to integrate and expand cancer pipeline programs and junior investigator mentorship. Under Sweasy’s direction, Research Programs and Shared Resources were also reviewed and reorganized for greater impact; internal funding opportunities and Innovative Working Groups were expanded to promote transdisciplinary collaboration and coordination; a multi-year recruitment effort was initiated based on the new Strategic Plan; rigorous methods were implemented to ensure cancer relevance of metrics; and an unprecedented collaboration was formed with Banner Health – Tucson to foster clinical research and care.