University of Arizona Cancer Center - Cancer Center Support Grant

总体：摘要 亚利桑那大学癌症中心（UACC）是美国唯一的国家癌症研究所（NCI）指定的 癌症中心总部设在亚利桑那州。UACC成立于45年前， 担任亚利桑那大学癌症研究的推动者，在集水区，并在 亚利桑那州。UACC的愿景是成为克服癌症风险，改善治疗， 培训有才华的科学家和供应商，并通过共同的决心参与社区， 发现、创新和消除社会不平等。这一愿景是通过UACC的使命来实现的， 减轻癌症对五个县集水区及其他地区的患者和家庭的负担 通过：（1）通过跨学科合作和团队科学寻求科学发现;（2） 在患者的癌症旅程中增加对最新方法的访问;（3）为几代人做好准备， 研究人员和卫生专业人员每天都在与癌症和影响弱势群体的不平等作斗争， （4）在尊重、一致和 共同的信念Joann Sweasy博士于2020年被任命为UACC主任，并促进了参与度 癌症中心的领导人和成员围绕这一使命和愿景。斯韦西发起了一项强有力的战略 规划过程，导致制定了2020 - 2025年战略计划，"战胜癌症"， 强调围绕中心范围内三个高度相关的科学主题开展跨学科合作 UACC的集水区：癌症与环境;癌症成像和生物工程;和小说 治疗和预防干预。UACC的151名成员来自11所学院和36所大学。 部门总资金为3380万美元（DC），其中包括2610万美元的同行评审资金，其中1160万美元 (44%）来自NCI，1300万美元（50%）来自其他国立卫生研究院机构。这代表了一个几乎 与项目前期相比，同行评审资金增加20%。值得注意的是，UACC收到了 在此期间，NCI补充了270万美元。2020年，共有2，835名患者参加了干预性试验， 与2016年相比，应计利润增长超过300%或3倍。在项目期间， 启动了社区外联和参与，并启动了人口健康评估， 更深入地了解集水区;癌症研究培训和教育协调办公室 还建立了整合和扩大癌症管道计划和初级研究员指导。下 Sweasy的方向，研究计划和共享资源也进行了审查和重组， 更大的影响;扩大了内部筹资机会和创新工作组，以促进 跨学科合作与协调;根据新的《联合国志愿人员组织法》启动了多年征聘工作， 战略计划;实施严格的方法以确保指标与癌症的相关性;以及 与Banner Health-Tucson建立了前所未有的合作关系，以促进临床研究和护理。

OVERALL: ABSTRACT The University of Arizona Cancer Center (UACC) is the only National Cancer Institute (NCI)-designated Cancer Center headquartered in the state of Arizona. UACC was established over 45 years ago and has served as the driver of cancer research at the University of Arizona, within the Catchment Area, and in the state of Arizona. UACC’s vision is to be a national leader for overcoming cancer risks, improving treatments, training talented scientists and providers, and engaging communities though a shared determination to discover, innovate, and remove social inequities. This vision is realized through UACC’s mission, which is to alleviate the burden of cancer on patients and families within a five-county Catchment Area and beyond through: (1) a quest for scientific discovery through interdisciplinary collaboration and team science; (2) increasing access to the latest approaches throughout a patient’s cancer journey; (3) preparing generations of researchers and health professionals to fight each day against cancer and the inequities affecting vulnerable populations; and (4) providing national leadership in engaging populations with respect, consistency, and shared conviction. Joann Sweasy, PhD, was appointed UACC Director in 2020 and has promoted engagement of cancer center leaders and members around this mission and vision. Sweasy initiated a robust strategic planning process that led to development of the 2020–2025 Strategic Plan, “Bear Down on Cancer”, emphasizing transdisciplinary collaboration around three Center-wide scientific themes that are highly relevant to UACC’s Catchment Area: Cancer and the Environment; Cancer Imaging and Bioengineering; and Novel Therapeutics and Preventive Interventions. UACC draws its 151 members from 11 colleges and 36 departments. Total funding is $33.8M (DC), which includes $26.1M in peer-reviewed funding of which $11.6M (44%) is from NCI and $13M (50%) from other National Institutes of Health agencies. This represents a nearly 20% increase in peer-reviewed funding compared to the prior project period. Of note, UACC has received $2.7M in NCI supplements during this period. In 2020, 2,835 patients were accrued to interventional trials, a more than 300% or 3-fold increase in accruals compared to 2016. During the project period, the Office of Community Outreach & Engagement was launched, and a population health assessment was initiated to profile the Catchment Area more deeply; an Office of Cancer Research Training & Education Coordination was also established to integrate and expand cancer pipeline programs and junior investigator mentorship. Under Sweasy’s direction, Research Programs and Shared Resources were also reviewed and reorganized for greater impact; internal funding opportunities and Innovative Working Groups were expanded to promote transdisciplinary collaboration and coordination; a multi-year recruitment effort was initiated based on the new Strategic Plan; rigorous methods were implemented to ensure cancer relevance of metrics; and an unprecedented collaboration was formed with Banner Health – Tucson to foster clinical research and care.