The Effect of Acoustic Enhancement of Slow-Wave Activity on Cognitive Control and Emotional Reactivity in Young Adults with Anxiety and Depression Symptoms

慢波活动的声学增强对患有焦虑和抑郁症状的年轻人的认知控制和情绪反应性的影响

• 批准号: 10678866
• 负责人: Michelle Elizabeth Stepan
• 金额: $ 17.47万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678866
• 关键词: Acoustic Stimulation; Acoustics; Affective; Amygdaloid structure; Anterior; Anxiety; Anxiety Disorders; Arousal; Aversive Stimulus; Behavior assessment; Brain; Clinical; Cognitive; Coupling; Crossover Design; Development; Devices; Diagnostic; Dorsal; Electroencephalography; Emotional; Female; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Health behavior; Image; Individual; Inferior; Insula of Reil; Investigational Therapies; Knowledge; Measures; Mental Depression; Mental Health; Mental disorders; Mentorship; Modeling; Mood Disorders; National Institute of Mental Health; Neuronal Plasticity; Onset of illness; Outcome; Parietal Lobe; Participant; Patient Self-Report; Patient-Focused Outcomes; Performance; Physiological; Play; Polysomnography; Positioning Attribute; Predictive Factor; Prefrontal Cortex; Preventive treatment; Principal Investigator; Process; Psychiatry; REM Sleep; Randomized; Recording of previous events; Research; Research Activity; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Schedule; Science; Scientist; Sleep; Sleep Architecture; Sleep Stages; Sleep disturbances; Slow-Wave Sleep; Synapses; Techniques; Testing; Thalamic structure; Therapeutic; Training; Training Activity; Universities; Work; adequate sleep; affective neuroscience; anxiety symptoms; career; cingulate cortex; cingulate gyrus; circadian; cognitive control; cognitive process; comorbidity; density; depressive symptoms; disorder prevention; emotion regulation; experience; improved; information processing; innovation; medical schools; negative affect; neural circuit; neurobehavioral; primary outcome; programs; skills; sleep health; therapeutic target; treatment of anxiety disorders; young adult

PROJECT SUMMARY/ABSTRACT Anxiety and mood disorders are the most common psychiatric conditions. They are also highly comorbid, and co-occurrence is associated with worse patient outcomes. Neurobehavioral dysfunction in cognitive control and emotional reactivity are considered fundamental mechanisms of disorder onset and progression. To inform effective preventative treatments, it is critical to identify modifiable factors that directly impact these transdiagnostic processes. Sleep is one such factor. The deepest stage of sleep, slow-wave sleep, is consistently reduced in most psychiatric conditions and can be modified using a variety of techniques. Slow-wave sleep predominates over the prefrontal cortex, providing particular benefit to cognitive processes, including cognitive control. Cognitive control is instrumental in downregulating negative affect to aversive stimuli. The aim of the current study is to elucidate the role of slow-wave sleep in cognitive control and emotional reactivity to aversive stimuli. We will study 40 young adults with elevated anxiety and depression symptoms and sleep disturbance. Participants will complete two overnights in our sleep lab with polysomnography to assess sleep architecture. Participants will also wear an acoustic stimulation device to enhance slow-wave sleep. During one of the overnights, the device will play sub-arousal tones to boost slow-wave sleep; during the other overnight, tone volume will be zero. The day after each overnight, participants will complete assessments of cognitive control and emotional reactivity in an fMRI scanner. We will examine effects of acoustic enhancement of slow-wave sleep on neurobehavioral measures of cognitive control and emotional reactivity and whether improvements in emotional reactivity occur through cognitive control improvements. This study will elucidate sleep-based mechanisms of anxiety and mood disorder onset in an at-risk sample and inform innovative, targeted, accessible sleep preventative treatments. The candidate possesses skills in sleep manipulation, polysomnography, and assessment of cognitive processes to conduct the proposed research. With additional critical training in 1) advanced targeted sleep manipulation and sleep EEG spectral analysis, 2) cognitive-affective neuroscience and fMRI, and 3) clinical knowledge and treatment of anxiety and mood disorders, the Principal Investigator will obtain the skills necessary to develop an independent research program focused on sleep and mental health. Training and research activities for the current proposal will be completed at the University of Pittsburgh School of Medicine. The Department of Psychiatry and the Center for Sleep and Circadian Science are leaders in sleep and mental health research and devoted to the professional development of early career scientists. The candidate has assembled a mentorship team of experienced independent researchers and clinicians with expertise in the proposed research aims and a successful history of mentorship. The intellectual and material resources provided by the University of Pittsburgh, combined with the proposed mentorship team’s guidance strongly position the candidate to achieve her proposed training, research, and career goals.

项目概要/摘要 焦虑和情绪障碍是最常见的精神疾病。他们也有高度共病，并且 同时发生与较差的患者预后相关。认知控制和神经行为功能障碍 情绪反应被认为是疾病发生和进展的基本机制。告知 有效的预防性治疗，确定直接影响这些的可改变因素至关重要 跨诊断过程。睡眠就是这样的因素之一。睡眠的最深阶段，即慢波睡眠，持续存在 在大多数精神疾病中，这种现象都会减少，并且可以使用多种技术进行修改。慢波睡眠 主导前额皮质，为认知过程提供特别的好处，包括认知 控制。认知控制有助于下调厌恶刺激的负面影响。该组织的目标是 目前的研究旨在阐明慢波睡眠在认知控制和厌恶情绪反应中的作用 刺激。我们将研究 40 名患有严重焦虑和抑郁症状以及睡眠障碍的年轻人。 参与者将在我们的睡眠实验室完成两晚的多导睡眠图评估睡眠结构。 参与者还将佩戴声刺激装置来增强慢波睡眠。期间之一 晚上，该设备将播放亚唤醒音以促进慢波睡眠；在另一晚，语气 体积将为零。每个过夜后的第二天，参与者将完成认知控制的评估 以及功能磁共振成像扫描仪中的情绪反应。我们将研究慢波声学增强的效果 睡眠对认知控制和情绪反应的神经行为测量的影响，以及是否改善 情绪反应是通过认知控制的改善而发生的。这项研究将阐明基于睡眠的 危险样本中焦虑和情绪障碍发生的机制，并提供创新、有针对性、易于理解的信息 睡眠预防治疗。候选人拥有睡眠控制、多导睡眠图和睡眠监测方面的技能 评估认知过程以进行拟议的研究。在 1) 中进行额外的关键培训 先进的有针对性的睡眠操纵和睡眠脑电图频谱分析，2）认知情感神经科学和 fMRI，以及 3) 焦虑和情绪障碍的临床知识和治疗，首席研究员将 获得开发专注于睡眠和心理健康的独立研究项目所需的技能。 当前提案的培训和研究活动将在匹兹堡大学学院完成 医学。精神病学系和睡眠与昼夜节律科学中心是睡眠领域的领导者 和心理健康研究，致力于早期职业科学家的专业发展。这 候选人组建了一支由经验丰富的独立研究人员和临床医生组成的导师团队 拟议研究目标的专业知识和成功的指导历史。智力和物质 匹兹堡大学提供的资源，结合拟议的导师团队的指导 强烈定位候选人以实现她提出的培训、研究和职业目标。