Mentoring and Patient Oriented Research in Cardiovascular Health and Digital Data Science

项目 摘要/摘要 心血管病 相联 预付款 这个 传感器 曝光。 很容易 分析 导电 集成 问题 焦点 和 谁 和 毕业生， 目标 劳动力市场。“ 能力 K24 数据 表型 健康状况 (CV)疾病影响了近一半的美国成年人。虽然达到了理想的简历健康，但我还是S 由于死亡率和发病率较低，许多人正在努力改变心血管疾病的健康行为。 在精准医学领域，更好地针对这些行为来改善心血管健康提供了希望。完毕 过去十年，数字数据呈指数级增长(例如社交媒体、在线搜索、远程 措施)由个人产生，反映其健康行为、态度和环境 但是，这些数据源通常未与经过验证的度量相链接、未处理且未 可解释用于研究或临床实践。我的研究组合一直专注于收集和 CV专注于数字数据，用于洞察、预测和临床应用。我的职业重点是 高影响力的面向客户的研究(POR)，以更好地了解如何最好地访问、分析和 这些数据是以患者为中心的，应用程度很高。这包括侧重于以下方面的工作 与隐私、安全和患者偏好相关。这项K24奖励将支持我的受保护时间 目前：1)实施研究计划，以促进个人简历健康和数字数据科学的POR 2)培训一批在开展这项工作的方法方面受过良好培训的调查人员 将是未来POR在这一研究领域的领导者。这项建议侧重于开发 执行全面和结构化的导师计划，以支持学员(本科生、 研究员，教师)，用于研究和职业发展。这一重点与NHLBIS总体一致 在“数据科学”和“进一步发展、多样化和维持以NHLBI为重点的科学 该提案建立在我当前的NHLBI R01、R21和基金会拨款基础上，并将支持我的 在临床试验、社交媒体道德和学术领导力方面进行以职业为导向的培训。这 还将支持两个新的研究领域：1)使用大型数字媒体构建计算模型 用于实时监测可修改的心血管健康行为的人群级别设置，2)发展中的患者 反映使用和参与，可为数字干预提供信息，以解决可修改的简历 行为。 一个 P， 这个K24的环境是宾夕法尼亚大学-一所世界知名的机构 拥有广泛的资源来支持医学、计算机科学、 通信和工程--对推进这项研究和支持跨学科至关重要的领域 实习生。K24的重点领域代表了精确医学和数字表型的新前沿 对于简历健康，可以由训练有素的跨学科POR研究人员来推动和领导。

Project Summary/Abstract Cardiovascular associated Advances the sensor exposures. easily analyzing conducting integrate issues focus and who and graduate, objectives workforce.” ability K24 data phenotypes health (CV) disease affects nearly half of all adult Americans. Although achieving “ideal CV health” i s with lower mortality nd morbidity, many individuals struggle with modifying CV health behaviors. in precision medicine offer promise in better targeting these behaviors to improve CV health. Over past decade, there has been exponential growth in digital data (e.g. social media, online search, remote measures) generated by individuals which reflects their health behaviors, attitudes, and environmental These data sources however are often not linked with validated measures, unprocessed, and not interpretable for use in research or clinical practice. My research portfolio has focused on collecting and CV focused digital data for insights, prediction, and clinical applications. My career focus is on high-impact atient-oriented research (POR) t o better understand how to best access, analyze and these data in a way that is patient-centered and highly applied. This includes work which focuses on related to privacy, security, and patient preferences. This K24 award will support protected time for me i ntently on: 1) implementing a research program to advance POR in CV health and digital data science 2) training a pipeline of investigators who are well trained in methodologies for conducting this work and will be future POR leaders i n this area of study. This proposal focuses on necessary steps for developing executing a comprehensive and structured mentorship program that will support mentees (undergraduate, fellow, faculty) for research and career development. This focus aligns with NHLBIs overarching in “data science” and “further developing, diversifying and sustaining a NHLBI focused scientific This proposal builds on my current NHLBI R01, R21, and Foundation grants and will support my to pursue career-oriented training in clinical trials, social media ethics, and academic leadership. This will also support two new areas of research: 1) building computational models using large digital media sets for population-level surveillance of modifiable CV health behaviors in real time, 2) developing patient reflecting use and engagement which can inform digital interventions to address modifiable CV behaviors. a p , The environment for this K24 is the University of Pennsylvania-a world renowned institution with extensive resources to support research at the intersection of medicine, computer science, communication, and engineering—fields critical for advancing this research and supporting interdisciplinary trainees. The areas of focus for this K24 represent new frontiers in precision medicine and digital phenotyping for CV health that can be advanced and led by well-trained interdisciplinary POR researchers.