iPSC-CM Modeling to Define Sodium-Calcium Dysfunction in Heart Failure

iPSC-CM 建模定义心力衰竭中的钠钙功能障碍

基本信息

  • 批准号:
    10677713
  • 负责人:
  • 金额:
    $ 51.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Project Summary Heart failure (HF) continues to have a major clinical and economic burden with stagnation in new therapies over the past two decades. A significant barrier to improved therapies is the incomplete understanding of the role of Na+/Ca2+ dysregulation in HF and its contribution to electrical and mechanical dysfunction. Project 1 of this Program Project Grant (PPG) aims to elucidate the role of Na+/Ca2+ dysregulation in electro-mechanical dysfunction associated with (HF) using human induced pluripotent stem cell-derived cardiomyocytes (iPSC- CMs) based modeling. The Project will first phenotype DCM iPSC-CMs from individuals with heterogeneous causative variants and genome edited controls. Then the role of molecular pathways that regulate Na+/Ca2+ homeostasis will be examined in each of the iPSC-CMs to define major pathways implicated in electro- mechanical dysfunction and delineate genotype-specific mechanisms within DCM. Drug treatment cellular responses and gene expression profiles will then be used to define genotype-specific drug responses and novel drug targets. We are well positioned to achieve the project goals within five years. The ability to define genotype-based mechanisms and drug treatments within HF is well aligned with NIH and NHLBI goals of precision medicine models.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Joseph C. Wu其他文献

Clinical Neurochemical Implications of Sleep Deprivation's Effects on the Anterior Cingulate of Depressed Responders
睡眠剥夺对抑郁反应者前扣带回影响的临床神经化学意义
  • DOI:
    10.1016/s0893-133x(01)00336-0
  • 发表时间:
    2001
  • 期刊:
  • 影响因子:
    7.6
  • 作者:
    Joseph C. Wu;M. Buchsbaum;W. Bunney
  • 通讯作者:
    W. Bunney
In Vivo Tomographic Cardiac Imaging: Positron Emission Tomography and Magnetic Resonance Imaging
体内断层心脏成像:正电子发射断层扫描和磁共振成像
  • DOI:
    10.1002/9781118495148.ch34
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    14
  • 作者:
    B. Huber;P. Nguyen;Joseph C. Wu
  • 通讯作者:
    Joseph C. Wu
Evaluating Gene and Cell Therapy
评估基因和细胞疗法
A novel platform device for rodent echocardiography.
一种用于啮齿动物超声心动图的新型平台装置。
  • DOI:
    10.1093/ilar.49.2.e1
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    I. Kutschka;Ahmad Y. Sheikh;R. Sista;S. Hendry;H. Chun;G. Hoyt;Werner Kutschka;M. Pelletier;T. Quertermous;Joseph C. Wu;R. Robbins
  • 通讯作者:
    R. Robbins
Nanocrown electrodes for reliable and robust intracellular recording of cardiomyocytes and cardiotoxicity screening
纳米冠电极用于可靠、稳健的心肌细胞内记录和心脏毒性筛查
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Z. Jahed;Yang Yang;Ching;Ethan P. Foster;Allister F. McGuire;Huaxiao Yang;Aofei Liu;Csaba Forró;Zenguang Yan;Xinghong Jiang;Ming;Wei Zhang;Xiao Li;Thomas L. Li;Annalisa Pawlosky;Joseph C. Wu;B. Cui
  • 通讯作者:
    B. Cui

Joseph C. Wu的其他文献

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{{ truncateString('Joseph C. Wu', 18)}}的其他基金

Modeling Cardiovascular Risks of Air Pollutants with Human Induced Pluripotent Stem Cell-Derived Cardiovascular-Associated Cells (Project 3) for the Air pollution disrupts Inflammasome Regulation in
使用人类诱导多能干细胞衍生的心血管相关细胞(项目 3)模拟空气污染物的心血管风险,以了解空气污染扰乱炎症体调节的情况
  • 批准号:
    10460332
  • 财政年份:
    2021
  • 资助金额:
    $ 51.4万
  • 项目类别:
Modeling Cardiovascular Risks of Air Pollutants with Human Induced Pluripotent Stem Cell-Derived Cardiovascular-Associated Cells (Project 3) for the Air pollution disrupts Inflammasome Regulation in
使用人类诱导多能干细胞衍生的心血管相关细胞(项目 3)模拟空气污染物的心血管风险,以了解空气污染扰乱炎症体调节的情况
  • 批准号:
    10269336
  • 财政年份:
    2021
  • 资助金额:
    $ 51.4万
  • 项目类别:
Human iPSC Model for Elucidating Crosstalk Signaling and Secretomes: Down Syndrome Administrative Supplement
用于阐明串扰信号和分泌组的人类 iPSC 模型:唐氏综合症行政补充
  • 批准号:
    9897087
  • 财政年份:
    2019
  • 资助金额:
    $ 51.4万
  • 项目类别:
Admin Core (Wu)
管理核心(吴)
  • 批准号:
    10249144
  • 财政年份:
    2019
  • 资助金额:
    $ 51.4万
  • 项目类别:
Admin Core (Wu)
管理核心(吴)
  • 批准号:
    10677708
  • 财政年份:
    2019
  • 资助金额:
    $ 51.4万
  • 项目类别:
Elucidating Electro-Mechanical Dysfunction in Heart Failure with Human Stem Cell Models
用人类干细胞模型阐明心力衰竭中的机电功能障碍
  • 批准号:
    10471335
  • 财政年份:
    2019
  • 资助金额:
    $ 51.4万
  • 项目类别:
iPSC-CM Modeling to Define Sodium-Calcium Dysfunction in Heart Failure
iPSC-CM 建模定义心力衰竭中的钠钙功能障碍
  • 批准号:
    10471338
  • 财政年份:
    2019
  • 资助金额:
    $ 51.4万
  • 项目类别:
Elucidating Electro-Mechanical Dysfunction in Heart Failure with Human Stem Cell Models
用人类干细胞模型阐明心力衰竭中的机电功能障碍
  • 批准号:
    10006331
  • 财政年份:
    2019
  • 资助金额:
    $ 51.4万
  • 项目类别:
iPSC-CM Modeling to Define Sodium-Calcium Dysfunction in Heart Failure
iPSC-CM 建模定义心力衰竭中的钠钙功能障碍
  • 批准号:
    10249147
  • 财政年份:
    2019
  • 资助金额:
    $ 51.4万
  • 项目类别:
iPSC-CM Modeling to Define Sodium-Calcium Dysfunction in Heart Failure
iPSC-CM 建模定义心力衰竭中的钠钙功能障碍
  • 批准号:
    10006340
  • 财政年份:
    2019
  • 资助金额:
    $ 51.4万
  • 项目类别:

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