Engineering Core C

工程核心C

• 批准号: 10681342
• 负责人: MICHAEL R BAILEY
• 金额: $ 20.34万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681342
• 关键词: Acoustics; Automobile Driving; Calibration; Certification; Clinical Trials; Code; Computer software; Core Assembly; Custom; Data; Devices; Doctor of Philosophy; Electronics; Engineering; Ensure; Equipment; Excision; Focused Ultrasound Therapy; Funding; Goals; Image; Industrialization; Industry; International; Investigation; Laboratories; Lithotripsy; Measurement; Medical; Methods; Military Personnel; Noise; Output; Physics; Physiologic pulse; Program Research Project Grants; Quality Control; Reproducibility of Results; Research; Safety; Shock; System; Time; Transducers; Translational Research; Ultrasonic Therapy; Ultrasonic Transducer; Ultrasonics; Ultrasonography; Universities; Urinary Calculi; Validation; Washington; Work; clinic ready; cost; design; experience; experimental study; fabrication; flexibility; instrument; instrumentation; pre-clinical; programs; prototype; repaired; tool; ultrasound

PROJECT SUMMARY/ABSTRACT - Engineering Core (Core C) The Program will include an Engineering Core (Core C) co-led by Michael R. Bailey, Ph.D. and R. Lee Thompson Ph.D. and housed in the Applied Physics Laboratory (APL) Transducer Array Fabrication Laboratory. There is no off-the-shelf hardware to perform ultrasonic propulsion (UP) or burst wave lithotripsy (BWL). This instrumentation is all custom built and requires specific expertise to create driving electronics and transducers capable of safely and reliably generating the required outputs. These transducers produce outputs different from typical high intensity focused ultrasound (HIFU) transducers and shock wave lithotripters and require specific drive electronics to produce appropriate pulse types. Companies who develop traditional HIFU devices and lithotripters have little or no experience with the design constraints of UP or BWL devices. No single commercially available system or transducer can produce the large range of outputs desired for the parametric investigation performed in Project 2, so several similar transducers must be made and calibrated. Core C is one of a handful of facilities internationally with expertise and experience in fabricating imaging and therapy ultrasound systems for industry and research, and thus, is unique in its ability to support this Program Project Grant. Core C will provide design, fabrication, and characterization support for the ultrasound transducers and control/power electronics to be used by our research teams. The overall goal of Core C is to ensure that all experiments are conducted with appropriate, calibrated, and accurate instrumentation. To accomplish that goal, Core C has three specific aims. Aim 1 is to produce and maintain identical hardware systems across for all three Projects. This work ensures that the Projects have the correct tools to perform their studies. Aim 2 is to certify and maintain calibration of the UP and BWL hardware for all three Projects. This work establishes a quality control framework acceptable to FDA for rigorous and reproducible results. Aim 3 is to engineer new hardware to produce desired outputs and configurations needed for specific applications by each of the three Projects. As research progresses, we expect to determine specific outputs or combinations of outputs that will enhance stone specific (S-mode) ultrasound imaging, BWL, and UP applications. These enhancements may impose new requirements on the range of outputs needed from a transducer or electronics. As such, in order to accomplish the proposed Project Aims, Core C will design and fabricate new transducers or electronics, and perform firmware and software coding of the outputs, and synchronization across outputs to meet the project requirements.

项目总结/摘要-工程核心（核心C） 该计划将包括一个工程核心（核心C）由迈克尔R。贝利博士和R.李 汤普森博士并安置在应用物理实验室（APL）换能器阵列制造实验室中。 没有现成的硬件来执行超声推进（UP）或爆破波碎石术（BWL）。这 仪器都是定制的，需要特定的专业知识来创建驱动电子设备和传感器 能够安全可靠地产生所需的输出。这些传感器产生的输出不同于 典型的高强度聚焦超声（HIFU）换能器和冲击波碎石机，并且需要特定的 驱动电子设备以产生适当的脉冲类型。开发传统HIFU设备的公司， 碎石机对UP或BWL器械的设计限制几乎没有经验或没有经验。没有一个商业 现有的系统或传感器可以产生参数研究所需的大范围输出 在项目2中，必须制造和校准几个类似的传感器。核心C是为数不多的 在制造成像和治疗超声系统方面具有专业知识和经验的国际设施 为工业和研究，因此，在其能力，以支持这一计划项目补助金是独一无二的。 核心C将为超声换能器提供设计、制造和表征支持， 控制/电力电子产品将由我们的研究团队使用。核心C的总体目标是确保所有 用适当的、校准的和精确的仪器进行实验。为了实现这一目标， 核心C有三个具体目标。目标1是为这三个系统生产和维护相同的硬件系统 项目这项工作确保项目拥有进行研究的正确工具。目标2是证明 并维护所有三个项目的UP和BWL硬件的校准。这项工作建立了一个质量 FDA可接受的控制框架，以获得严格和可重现的结果。目标3是设计新硬件 产生三个项目中每个项目的特定应用所需的预期输出和配置。作为 研究进展，我们希望确定具体的输出或输出的组合，将提高石头 特定（S模式）超声成像、BWL和UP应用。这些改进可能会带来新的 对传感器或电子设备所需输出范围的要求。因此，为了实现 拟议的项目目标是，核心C将设计和制造新的传感器或电子设备，并执行 输出的固件和软件编码，以及输出之间的同步，以满足项目要求 要求.