Redox regulation of protein functions linked to neurodegeneration
与神经变性相关的蛋白质功能的氧化还原调节
基本信息
- 批准号:10679058
- 负责人:
- 金额:$ 35.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-25 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAmyotrophic Lateral SclerosisAntibodiesAntisense OligonucleotidesAutophagocytosisBinding ProteinsBiochemicalBiological AssayBiological MarkersBiologyBrainCell DeathCell LineCell physiologyCellsCoupledCytoplasmDevelopmentGleanGrowthHealthHumanHydrogen PeroxideIndividualKnowledgeLinkMammalian CellMass Spectrum AnalysisMediatingMetabolicMetabolismMethionineMethodsMitochondriaMolecularMotor NeuronsMusMutateMutationMutation AnalysisNerve DegenerationNeurodegenerative DisordersNeuronsOrthologous GeneOutputOxidation-ReductionOxidative StressPathologyPhasePhenotypePhysical condensationProtein EngineeringProtein FootprintingProteinsRNARNA Recognition MotifRNA-Binding ProteinsRegulationReporterRespirationSCA2 proteinSignal TransductionSpinocerebellar AtaxiasStressTherapeuticTissue SampleVariantYeastsexperimental studyimprovedinnovationinsightinterestmetabolomicsmitochondrial dysfunctionmutantnoveloverexpressionoxidationpolyglutamineprotein TDP-43protein functionrecruitrespiratoryresponsesensorstress granuletherapeutic targettreatment strategyyeast protein
项目摘要
Project Summary/Abstract:
The molecular and metabolic mechanisms that go awry during the course of neurodegeneration
remain poorly understood. A conserved protein called ataxin-2 has been linked to
neurodegeneration due to the occurrence of polyglutamine tract expansions that can influence
the aggregation of itself and other proteins. However, the normal functions of this protein and
the consequences of their alteration have not been clear. It was recently shown that the protein
can function as a redox sensor to then regulate cellular metabolism and signaling in a manner
that sustains mitochondrial health and cell survivability. This proposal will investigate aspects of
the mechanism of redox sensing by ataxin-2 in both yeast and mammalian cells, the
downstream outputs, as well as the consequences of mutations and variants on associated
cellular functions.
项目总结/文摘:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Benjamin P Tu其他文献
Benjamin P Tu的其他文献
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{{ truncateString('Benjamin P Tu', 18)}}的其他基金
Metabolic signals regulating cell growth versus survival
调节细胞生长与存活的代谢信号
- 批准号:
10334542 - 财政年份:2020
- 资助金额:
$ 35.88万 - 项目类别:
Metabolic signals regulating cell growth versus survival
调节细胞生长与存活的代谢信号
- 批准号:
10551221 - 财政年份:2020
- 资助金额:
$ 35.88万 - 项目类别:
Redox regulation of protein functions linked to neurodegeneration
与神经变性相关的蛋白质功能的氧化还原调节
- 批准号:
10267703 - 财政年份:2019
- 资助金额:
$ 35.88万 - 项目类别:
Redox regulation of protein functions linked to neurodegeneration
与神经变性相关的蛋白质功能的氧化还原调节
- 批准号:
9917330 - 财政年份:2019
- 资助金额:
$ 35.88万 - 项目类别:
Redox regulation of protein functions linked to neurodegeneration
与神经变性相关的蛋白质功能的氧化还原调节
- 批准号:
10707560 - 财政年份:2019
- 资助金额:
$ 35.88万 - 项目类别:
Redox regulation of protein functions linked to neurodegeneration
与神经变性相关的蛋白质功能的氧化还原调节
- 批准号:
10904159 - 财政年份:2019
- 资助金额:
$ 35.88万 - 项目类别:
Redox regulation of protein functions linked to neurodegeneration
与神经变性相关的蛋白质功能的氧化还原调节
- 批准号:
10302940 - 财政年份:2019
- 资助金额:
$ 35.88万 - 项目类别:
Redox regulation of protein functions linked to neurodegeneration
与神经变性相关的蛋白质功能的氧化还原调节
- 批准号:
10474399 - 财政年份:2019
- 资助金额:
$ 35.88万 - 项目类别:
Redox regulation of protein functions linked to neurodegeneration
与神经变性相关的蛋白质功能的氧化还原调节
- 批准号:
10025191 - 财政年份:2019
- 资助金额:
$ 35.88万 - 项目类别:
Metabolic signals driving cell growth and proliferation
驱动细胞生长和增殖的代谢信号
- 批准号:
8050252 - 财政年份:2010
- 资助金额:
$ 35.88万 - 项目类别:
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