Preclinical Core Component 3

临床前核心组件 3

• 批准号: 10679090
• 负责人: Lee Anna Cunningham
• 金额: $ 23.6万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10679090
• 关键词: Acceleration; Anatomy; Applications Grants; Area; Behavior; Behavioral; Biological Assay; Brain; Brain Injuries; Budgets; Clinical Investigator; Collaborations; Communities; Comprehensive Cancer Center; Computer software; Consultations; Data; Development; Documentation; Educational workshop; Electroencephalography; Ensure; Equipment; Experimental Designs; Fee-for-Service Plans; Fees; Fostering; Funding; Future; Goals; Grant; Image; Image Analysis; Income; Interdisciplinary Study; Investments; Laboratory Research; Malignant neoplasm of brain; Measures; Mentorship; Methodology; Methods; Mission; National Institute on Alcohol Abuse and Alcoholism; Neuroanatomy; Neurologic; Neurology; Neurosciences; Neurosciences Research; New Mexico; Outcome; Performance; Phase; Physiological; Play; Pre-Clinical Model; Procedures; Recovery; Reproducibility; Research; Research Design; Research Institute; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Rodent; Rodent Model; Role; Scanning; Schedule; Scientist; Site; Speed; Stroke; Structure; Survivors; System; Technical Expertise; Training; Translational Research; United States National Institutes of Health; Universities; Wing; addiction; alcohol exposure; alcohol research; base; behavior test; brain repair; cohort; confocal imaging; cost; design; functional improvement; improved; innovation; instrumentation; investigator training; man; multidisciplinary; nervous system disorder; neural; neurophysiology; neurosurgery; novel therapeutics; outreach; pre-clinical; pre-clinical research; programs; repaired; research facility; success; touchscreen; translational impact

PROJECT SUMMARY The Preclinical Core supports the mission of the Center for Brain Recovery and Repair by providing well- validated measures of both structural and functional alterations for investigators utilizing preclinical models of neurological disorders. The Core is a centralized resource providing intellectual guidance, technical expertise, training and instrumentation for high quality automated behavioral and structural analyses, broadly applicable across a range of preclinical models of brain and behavioral illnesses. Through cultivation of new research programs and collaborative interactions between young investigators and established experts, the Core has played an essential role in elevating the excellence of brain injury and repair research at UNM. Overall, the goal of the Core is to leverage our success in Phase I to catapult preclinical research capacity to the critical mass of funded investigators required to support the Center’s mission of self-sustainability beyond IDeA-level funding. We will continue to provide the resources and expertise required to support interdisciplinary cutting-edge research projects of Project Leads in neurophysiological mechanisms of brain recovery and repair, and to expand our user base of new and established investigators through project development and strategic investment in state-of-the-art instrumentation, approaches and methodologies. Via the cultivation of innovative new research programs and increased collaborative interactions between junior investigators and established scientists the Core will contribute to the sustainability of the Center for Brain Recovery and Repair as a nationally recognized leader for translational research in brain recovery. Since being established in 2015, the Preclinical Core has helped advance the field by leading in the development of translational EEG as a platform for assessing homology of neural activity during behaviors across species. Phase II builds on these successes with the combination of physiological and behavioral approaches, and adds higher throughput anatomical assessments to speed studies utilizing sophisticated confocal imaging. Continuing from Phase I, the Core will promote the Center mission of accelerating the trajectory of Project Leads toward independent NIH-R01 level funding for Junior Investigators or establishing themselves in the field of brain injury for more senior Investigators. The Preclinical Core will continue to foster multidisciplinary interactions between clinical and preclinical investigators at UNM and across the Mountain West. We will also provide a platform for the discovery of novel therapeutic avenues for brain recovery and repair using preclinical models that will enhance the overall level of excellence in this vital area of neuroscience research.

项目概要 临床前核心通过提供良好的服务来支持脑恢复和修复中心的使命 为研究人员利用临床前模型对结构和功能改变进行验证的测量 神经系统疾病。核心是一个集中资源，提供智力指导、技术专长、 高质量自动化行为和结构分析的培训和仪器，广泛适用 涵盖一系列大脑和行为疾病的临床前模型。通过培育新的研究 核心项目以及年轻研究者和知名专家之间的协作互动 在提升新墨西哥大学脑损伤和修复研究的卓越性方面发挥了重要作用。总体而言，目标 核心是利用我们在第一阶段的成功将临床前研究能力提升到临界质量 资助研究人员，以支持该中心超越 IDeA 级别资金的自我维持使命。 我们将继续提供支持跨学科前沿所需的资源和专业知识 项目负责人的研究项目涉及大脑恢复和修复的神经生理学机制，并 通过项目开发和战略，扩大我们的新老研究者的用户群 投资最先进的仪器、方法和方法。通过培养创新 新的研究计划以及初级研究人员和已建立的研究人员之间增加的合作互动 核心科学家将为脑恢复和修复中心作为国家级机构的可持续性做出贡献 公认的脑恢复转化研究领导者。自2015年成立以来，临床前研究中心 Core 通过引领转化脑电图作为评估平台的开发，帮助推动了该领域的发展 跨物种行为过程中神经活动的同源性。第二阶段建立在这些成功的基础上 生理和行为方法的结合，并增加了更高通量的解剖评估 利用复杂的共焦成像加速研究。从第一阶段开始，核心将促进 中心的使命是加速项目线索走向独立的 NIH-R01 级别资助 初级研究人员或为更高级的研究人员在脑损伤领域建立自己的地位。这 临床前核心将继续促进临床和临床前研究人员之间的多学科互动 在新墨西哥大学和西山区。我们还将提供一个发现新疗法的平台 使用临床前模型进行大脑恢复和修复的途径将提高整体卓越水平 在神经科学研究的这个重要领域。