Preclinical Core Component 3

临床前核心组件 3

• 批准号: 10679090
• 负责人: Lee Anna Cunningham
• 金额: $ 23.6万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10679090
• 关键词: Acceleration; Anatomy; Applications Grants; Area; Behavior; Behavioral; Biological Assay; Brain; Brain Injuries; Budgets; Clinical Investigator; Collaborations; Communities; Comprehensive Cancer Center; Computer software; Consultations; Data; Development; Documentation; Educational workshop; Electroencephalography; Ensure; Equipment; Experimental Designs; Fee-for-Service Plans; Fees; Fostering; Funding; Future; Goals; Grant; Image; Image Analysis; Income; Interdisciplinary Study; Investments; Laboratory Research; Malignant neoplasm of brain; Measures; Mentorship; Methodology; Methods; Mission; National Institute on Alcohol Abuse and Alcoholism; Neuroanatomy; Neurologic; Neurology; Neurosciences; Neurosciences Research; New Mexico; Outcome; Performance; Phase; Physiological; Play; Pre-Clinical Model; Procedures; Recovery; Reproducibility; Research; Research Design; Research Institute; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Rodent; Rodent Model; Role; Scanning; Schedule; Scientist; Site; Speed; Stroke; Structure; Survivors; System; Technical Expertise; Training; Translational Research; United States National Institutes of Health; Universities; Wing; addiction; alcohol exposure; alcohol research; base; behavior test; brain repair; cohort; confocal imaging; cost; design; functional improvement; improved; innovation; instrumentation; investigator training; man; multidisciplinary; nervous system disorder; neural; neurophysiology; neurosurgery; novel therapeutics; outreach; pre-clinical; pre-clinical research; programs; repaired; research facility; success; touchscreen; translational impact

PROJECT SUMMARY The Preclinical Core supports the mission of the Center for Brain Recovery and Repair by providing well- validated measures of both structural and functional alterations for investigators utilizing preclinical models of neurological disorders. The Core is a centralized resource providing intellectual guidance, technical expertise, training and instrumentation for high quality automated behavioral and structural analyses, broadly applicable across a range of preclinical models of brain and behavioral illnesses. Through cultivation of new research programs and collaborative interactions between young investigators and established experts, the Core has played an essential role in elevating the excellence of brain injury and repair research at UNM. Overall, the goal of the Core is to leverage our success in Phase I to catapult preclinical research capacity to the critical mass of funded investigators required to support the Center’s mission of self-sustainability beyond IDeA-level funding. We will continue to provide the resources and expertise required to support interdisciplinary cutting-edge research projects of Project Leads in neurophysiological mechanisms of brain recovery and repair, and to expand our user base of new and established investigators through project development and strategic investment in state-of-the-art instrumentation, approaches and methodologies. Via the cultivation of innovative new research programs and increased collaborative interactions between junior investigators and established scientists the Core will contribute to the sustainability of the Center for Brain Recovery and Repair as a nationally recognized leader for translational research in brain recovery. Since being established in 2015, the Preclinical Core has helped advance the field by leading in the development of translational EEG as a platform for assessing homology of neural activity during behaviors across species. Phase II builds on these successes with the combination of physiological and behavioral approaches, and adds higher throughput anatomical assessments to speed studies utilizing sophisticated confocal imaging. Continuing from Phase I, the Core will promote the Center mission of accelerating the trajectory of Project Leads toward independent NIH-R01 level funding for Junior Investigators or establishing themselves in the field of brain injury for more senior Investigators. The Preclinical Core will continue to foster multidisciplinary interactions between clinical and preclinical investigators at UNM and across the Mountain West. We will also provide a platform for the discovery of novel therapeutic avenues for brain recovery and repair using preclinical models that will enhance the overall level of excellence in this vital area of neuroscience research.

项目摘要 临床前核心支持中心的使命，为脑恢复和修复提供良好的- 为研究者利用临床前模型验证结构和功能改变的措施， 神经系统疾病核心是一个集中的资源，提供智力指导，技术专长， 用于高质量自动化行为和结构分析的培训和仪器，广泛适用 一系列大脑和行为疾病的临床前模型。通过培育新研究 项目和年轻研究人员与知名专家之间的合作互动，核心已经 在提升UNM脑损伤和修复研究的卓越性方面发挥了重要作用。总的来说，目标 的核心是利用我们在第一阶段的成功，以弹射临床前研究能力的临界质量， 资助的研究人员需要支持该中心的自我可持续性的使命超过IDEA级资金。 我们将继续提供所需的资源和专业知识，以支持跨学科的尖端 项目领导的研究项目，在脑恢复和修复的神经生理机制，并 通过项目开发和战略合作， 投资于最先进的仪器、方法和手段。通过培养创新能力 新的研究项目和增加初级研究人员之间的合作互动， 科学家的核心将有助于大脑恢复和修复中心的可持续性，作为一个国家 公认的大脑恢复转化研究的领导者。自2015年成立以来，临床前 Core通过领先开发转化EEG作为评估平台， 物种间行为过程中神经活动的同源性。第二阶段在这些成功的基础上， 结合生理和行为方法，并增加了更高通量的解剖评估 利用精密的共焦成像加速研究。从第一阶段开始，核心小组将促进 加速项目线索走向独立的NIH-R 01级资助的中心使命， 初级研究者或在脑损伤领域为更高级的研究者建立自己的地位。的 临床前核心将继续促进临床和临床前研究者之间的多学科互动 在新墨西哥大学和西山那边我们还将为发现新的治疗方法提供平台。 使用临床前模型进行大脑恢复和修复的途径，将提高整体卓越水平 神经科学研究的重要领域。