Alliance NCORP Research Base

联盟NCORP研究基地

• 批准号: 10679045
• 负责人: Evanthia Galanis
• 金额: $ 1051.78万
• 依托单位: ALLIANCE NCTN FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10679045
• 关键词: Academic Medical Centers; Address; Advocate; Aging; Area; Attention; Behavior; Blood; Cancer Burden; Cancer Patient; Cancer Research Project; Caregivers; Clinical; Clinical Oncology; Clinical Research; Clinical Trials; Collaborations; Collection; Committee Membership; Communities; Community Clinical Oncology Program; Companions; Data; Data Reporting; Databases; Development; Diagnosis; Disease; Disparity; Early Diagnosis; Education; Elderly; Functional disorder; Funding; Funding Opportunities; Grant; Health; Human; Incidence; Intervention; Maintenance; Malignant Neoplasms; Manuscripts; Mentors; Mentorship; Metastatic Neoplasm to the Bone; Metastatic malignant neoplasm to brain; Minority; Minority Groups; Mission; Monitor; Morbidity - disease rate; National Cancer Institute; National Clinical Trials Network; Natural History; Nausea and Vomiting; Oncologist; Oncology; Outcome; Outcome Assessment; Outcomes Research; Parents; Patient Outcomes Assessments; Patients; Pharmacologic Substance; Population; Prevalence; Prevention; Publishing; Quality of life; Research; Research Methodology; Research Personnel; Research Priority; Risk; Site; Source; Symptoms; Technology; Tissue Sample; Toxic effect; Training; Translational Research; Tumor Tissue; Underserved Population; United States; Work; base; cancer care; cancer clinical trial; cancer health disparity; cancer prevention; cancer risk; cancer therapy; care delivery; chemotherapy; clinically relevant; clinically significant; community engagement; curative treatments; data sharing; disparity elimination; disparity reduction; experience; financial toxicity; forging; health disparity; high risk; improved; innovation; mortality; multidisciplinary; next generation; novel; older patient; premalignant; prevent; programs; reduce symptoms; repository; skeletal-related events; survivorship; translational oncology; treatment trial; underserved community

Alliance NCORP Research Base Project Summary/Abstract The Alliance for Clinical Trials in Oncology (Alliance), one of five National Clinical Trials Network groups, serves as the parent organization for the Alliance NCI Community Oncology Research Program (NCORP) Research Base (Alliance NCORP). The Alliance NCORP conducts interventional and observational clinical and translational research as well as database studies – all of which address important questions relevant to cancer prevention, symptom control, and cancer care delivery. In addition, the Alliance NCORP conducts clinically important quality of life studies that are embedded within cancer treatment trials. It places special emphasis on minority, underserved and older patients at risk for or diagnosed with cancer, and on building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance NCORP committee membership includes rich representation from both community-based and academic medical centers, as well as patient advocates, thus generating research results relevant to cancer patients across the United States. The Alliance NCORP also emphasizes mentorship and training of junior investigators. Over this past grant cycle, i.e., since August 2014, the Alliance NCORP has published 148 manuscripts and abstracts. This work has included practice-changing research in such areas as the prevention of chemotherapy-induced nausea and vomiting, the prevention of skeletal-related events from osseous metastases, the management of brain metastases, and the integration of patient-reported outcomes into cancer clinical trials. The Alliance NCORP conducts translational research that requires the collection of tumor tissue, premalignant tissue samples, blood, and other human biospecimens; and shares data and biospecimens for pooled analyses and other scientific collaborations. These biospecimens create an invaluable repository for understanding clinical observations from a mechanistic standpoint. The Alliance NCORP also collaborates broadly with other NCI-funded investigators and consortia, as well as with investigators supported through non-NCI sources. This practice-changing research and the scientific questions answered by the Alliance NCORP provide meaningful and innovative contributions to clinical and translational oncology, which can be conducted only within a publicly-funded research network.

联盟NCORP研究基础 项目摘要/摘要 肿瘤学临床试验联盟（联盟），五个国家临床试验网络组之一， 作为联盟NCI社区肿瘤研究计划（NCORP）的母公司组织 研究基础（联盟NCORP）。联盟NCORP进行介入和观察性临床 并翻译研究以及数据库研究 - 所有这些都解决了与 预防癌症，控制和癌症护理。此外，联盟NCORP进行 临床重要的生活质量研究嵌入了癌症治疗试验中。它特别是 强调少数民族，服务不足和老年患者有癌症或诊断的患者以及建造 与NCORP社区网站和少数民族/服务不足的社区网站的牢固的合作关系。这 联盟NCORP委员会成员资格包括社区和 学术医疗中心以及患者的拥护者，从而产生与癌症有关的研究结果 美国各地的患者。联盟NCORP还强调了初中的精神和培训 调查人员。在过去的赠款周期中，即自2014年8月以来，联盟NCORP已发布148 手稿和摘要。这项工作包括在诸如等领域进行练习的研究 预防化学疗法引起的恶心和呕吐，预防与骨骼有关的事件 骨转移，脑转移的管理以及患者报告的结果的整合 进入癌症临床试验。联盟NCORP进行转化研究，需要收集 肿瘤组织，前组织样品，血液和其他人类生物测量；并共享数据和 用于汇总分析和其他科学合作的生物测量。这些生物测量创造了 从机械角度来理解临床观察的宝贵存储库。联盟 NCORP还与其他NCI资助的调查员和财团进行了广泛的合作，以及 调查人员通过非NCI来源支持。这项实践改变的研究和科学 联盟NCORP回答的问题为临床和 翻译肿瘤学，只能在公共资助的研究网络中进行。