2023 Pancreatic Diseases Gordon Research Conference and Gordon Research Seminar

项目摘要 戈登研究会议（GRC）是一组著名的，非营利的，国际科学会议 自1931年以来一直举行。本R13提案涉及胰腺疾病GRC：“胰腺 疾病：了解细胞行为和通信”和相关的受训者领导的戈登研究 研讨会（GRS），于2023年4月29日至5月5日在卢卡，意大利举行。近年来，我们的技术发展迅速， 了解胰腺发育、再生和恶性肿瘤的分子机制 转化，以及我们在小鼠和人类细胞中模拟这些过程的能力。这些研究 揭示了不同胰腺细胞类型之间的谱系关系，以及 环境影响。此外，流行病学研究表明，胰腺癌与糖尿病之间存在明显的相关性。 疾病，特别是糖尿病和胰腺癌之间。然而，参与合作的机制- 对胰腺疾病的发生知之甚少。本研究旨在将生物学的理解与 外分泌和内分泌胰腺的应用于人类疾病。本次会议的独特之处在于， 召集来自胰腺生物学各个方面的专家以及从事转化方法的临床医生， 治疗糖尿病、胰腺癌和胰腺炎。通过提供一个论坛， 前沿的，未发表的概念和方法，本GRC的目标是激发讨论， 学科这种交流将促进跨学科的方法，促进思想交流， 这将有助于促进合作，并使年轻科学家能够向该领域的同行和领导者展示他们的工作。 即将到来的第五届胰腺疾病GRC将专注于了解细胞行为和通信， 胰腺疾病，目的是深入了解系统和局部环境如何影响 内分泌和外分泌细胞的健康和疾病。已经组装的程序是一流的， 受益于从事不同领域相关研究的国际世界级科学家的贡献， 胰腺疾病的各个方面。会议的最终目标是确定新的概念， 胰腺疾病，可能是利用药理学和细胞为基础的治疗方法。作为 对于所有GRCs，本次会议的指导原则是介绍新的，未发表的结果和免费的， 不受阻碍的讨论。特别强调青年科学家的参与， 简短的演讲和海报展示的机会。为进一步增加职业发展机会， 戈登研究研讨会（GRS）已被纳入本次会议。发生在 在GRC本身，GRS的特色是由学员专门制作的海报和讲座，以及设计的导师课程 为学员提供愿意帮助指导其职业生涯的知名导师。总之，这使得一个罕见的 促进年轻研究人员的平台，将学员纳入跨学科胰腺疾病研究 社区，并在他们的培训的关键时刻影响他们的职业轨迹。

PROJECT SUMMARY Gordon Research Conferences (GRCs) are a group of prestigious, non-profit, international scientific conferences that have been held since 1931. This R13 proposal relates to the GRC on Pancreatic Diseases: "Pancreatic Diseases: Understanding cell behavior and communication” and the associated trainee-led Gordon Research Seminar (GRS), held April 29 - May 5, 2023, in Lucca, Italy. Recent years have brought rapid advances in our understanding of the molecular mechanisms underlying pancreatic development, regeneration, and malignant transformation, as well as our ability to model these processes in mice and human cells. These studies have revealed lineage relationships between the different pancreatic cell types and plasticity in response to environmental influences. Moreover, epidemiological studies show a clear association between pancreatic diseases, in particular between diabetes and pancreatic cancer. Yet, the mechanisms involved in the co- occurrence of pancreatic diseases are poorly understood. This GRC aims to link the understanding of the biology of the exocrine and endocrine pancreas to applications for human diseases. This conference is unique in that it convenes experts from all aspects of pancreas biology as well as clinicians working on translational approaches for diabetes, pancreatic cancer and pancreatitis. By providing a forum for the presentation and discussion of cutting edge, unpublished concepts and approaches, the goal of this GRC is to stimulate discussion across disciplines. This exchange will foster interdisciplinary approaches and promote exchange of ideas to lead to new collaborations, as well as empower young scientists to showcase their work to peers and leaders in the field. The upcoming, fifth Pancreatic Diseases GRC will focus on understanding cell behavior and communication in pancreatic diseases with the goal of gaining insights into how the systemic and local environment impact endocrine and exocrine cells in health and disease. The program that has been assembled is first-rate, benefitting from the contribution of international world-class scientists engaged in research relevant to different aspects of pancreatic diseases. The ultimate goal of the conference is the identification of novel concepts in pancreatic diseases that might be exploitable for pharmacological and cell-based therapeutic approaches. As for all GRCs, the guiding principle of this conference is the presentation of new, unpublished results and the free, unhampered discussion that follows. Participation of young scientists is especially emphasized, with opportunities of short talks and poster presentations. To further enhance career development opportunities, a Gordon Research Seminar (GRS) has been integrated into this meeting. Taking place immediately prior to the GRC proper, the GRS features posters and talks exclusively by trainees as well as mentorship sessions designed to provide trainees with established mentors willing to help guide their careers. Together, this makes for a rare platform to promote young researchers, integrate trainees into the interdisciplinary pancreatic disease research community, and impact their career trajectory at a critical time in their training.