The Lysophospholipid and Related Mediators Conference: From Bench to Clinic

摘要 FASE B溶血磷脂及其相关介体科学研究会议：从实验台到临床 将于2023年7月9日至7月13日在美国佛罗里达州墨尔本皇冠假日酒店举行。这次会议将讨论 主要与溶血磷脂1-磷酸鞘氨醇相关的研究现状和新概念 (S1P)和溶血磷脂酸(LPA)及其在健康和疾病中的作用。S1P和LPA是信号脂质 分别激活5G和6G蛋白偶联受体，并与细胞内靶蛋白结合进行调节 细胞生物学。这些生物相互作用控制着心血管系统、免疫系统、 和神经系统。这些脂质在肺纤维化、动脉粥样硬化、癌症、自身免疫、 和其他疾病状态。调节溶血磷脂代谢的受体和酶都已显示出来。 作为诊断、预防或治疗疾病的潜在治疗靶点。会议将强调 将这项工作转化为临床实践，并突出正在快速取得的研究进展 这一领域的许多新调查人员。这次会议为来自世界各地的科学家提供了一个独特而宝贵的论坛 不同学科的会议和讨论他们的最新研究成果。会议的目的是：1)提供 多学科的溶血磷脂研究人员与实习生之间的智力交流 研究；2)鼓励和促进早期职业和新调查人员之间的积极讨论 通过互动式职业研讨会和建立网络/协作的多种机会，成为知名科学家； 以及3)提供一个平台，促进妇女和代表性不足的少数群体的参与。这次会议 将允许不同的早期职业和成熟的研究人员交流最新的研究成果和 促进未来与溶血磷脂发挥作用的疾病的治疗相一致的互动 主要角色。在爱尔兰的会议地点将最大限度地促进欧洲科学家的参与， 来自国外的其他国家的科学家和美国同行促进富有成效的互动，重点是 溶血磷脂的翻译含义。

Abstract The FASEB Science Research Conference on Lysophospholipid and Related Mediators: From Bench to Clinic will be held July 9 - July 13, 2023 at the Crown Plaza Hotel, Melbourne, Florida, USA. This conference will address current research and emerging concepts related primarily to the lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) and their roles in health and disease. S1P and LPA are signaling lipids that activate 5 and 6 G protein-coupled receptors, respectively, and bind to intracellular target proteins to regulate cell biology. These biological interactions control vital functions in the cardiovascular system, the immune system, and the nervous system. These lipids are important in pulmonary fibrosis, atherosclerosis, cancer, autoimmunity, and other disease states. Both receptors and enzymes regulating lysophospholipid metabolism have been shown to function as potential therapeutic targets to diagnose, prevent or treat disease. The conference will emphasize the translation of this work into clinical practice and highlight the research advances being made at a rapid pace by many new investigators in this field. The meeting provides a unique and invaluable forum for scientists from diverse disciplines to meet and discuss their latest research findings. The conference aims are to 1) provide intellectual exchange between scientists and trainees from multiple disciplines engaged in lysophospholipid research; 2) encourage and facilitate active discussion between early career and new investigators and established scientists via interactive career workshops and multiple opportunities for networking/collaboration; and 3) provide a platform to promote the participation of women and underrepresented minorities. The conference will allow diverse early career and established investigators to communicate late-breaking research results and promote future interactions aligned with developing therapies for diseases in which lysophospholipids play a predominant role. The conference site in Ireland will facilitate maximum participation of European scientists, scientists from other countries abroad, and US counterparts to promote productive interactions focusing on the translational implications of lysophospholipids.