The Lysophospholipid and Related Mediators Conference: From Bench to Clinic

溶血磷脂及相关介质会议：从实验室到临床

基本信息

批准号：
10682798
负责人：
Annarita Di Lorenzo
金额：
$ 1万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-19 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10682798
关键词：
Address Atherosclerosis Autoimmune Diseases Autoimmunity Binding Biochemistry Biological Cardiovascular Diseases Cardiovascular system Cellular biology Child Child Care Collaborations Communication Complex Country Crowns Diagnosis Discipline Disease Drug Industry Drug Targeting Educational workshop Enzymes European Faculty Fees Fibrosis Florida Funding Future GPR6 gene Goals Grant Health Human Human Pathology Immune system Immunology Industry Interdisciplinary Study Ireland Knowledge Lipids Lysophosphatidic Acid Receptors Lysophospholipids Malignant Neoplasms Mediator Metabolic Metabolism Mission National Heart, Lung, and Blood Institute Nervous System Neurosciences Outcome Participant Pharmacologic Substance Play Postdoctoral Fellow Productivity Proteins Public Health Pulmonary Fibrosis Request for Applications Research Research Personnel Role Scholarship Science Scientist Signal Transduction Site Students System Translations Travel Underrepresented Minority Underrepresented Populations United States National Institutes of Health Woman Work bench to bedside career clinical practice human disease insight interest lysophosphatidic acid meetings multidisciplinary posters prevent receptor sphingosine 1-phosphate symposium therapeutic target therapy development translational scientist

项目摘要

Abstract The FASEB Science Research Conference on Lysophospholipid and Related Mediators: From Bench to Clinic will be held July 9 - July 13, 2023 at the Crown Plaza Hotel, Melbourne, Florida, USA. This conference will address current research and emerging concepts related primarily to the lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) and their roles in health and disease. S1P and LPA are signaling lipids that activate 5 and 6 G protein-coupled receptors, respectively, and bind to intracellular target proteins to regulate cell biology. These biological interactions control vital functions in the cardiovascular system, the immune system, and the nervous system. These lipids are important in pulmonary fibrosis, atherosclerosis, cancer, autoimmunity, and other disease states. Both receptors and enzymes regulating lysophospholipid metabolism have been shown to function as potential therapeutic targets to diagnose, prevent or treat disease. The conference will emphasize the translation of this work into clinical practice and highlight the research advances being made at a rapid pace by many new investigators in this field. The meeting provides a unique and invaluable forum for scientists from diverse disciplines to meet and discuss their latest research findings. The conference aims are to 1) provide intellectual exchange between scientists and trainees from multiple disciplines engaged in lysophospholipid research; 2) encourage and facilitate active discussion between early career and new investigators and established scientists via interactive career workshops and multiple opportunities for networking/collaboration; and 3) provide a platform to promote the participation of women and underrepresented minorities. The conference will allow diverse early career and established investigators to communicate late-breaking research results and promote future interactions aligned with developing therapies for diseases in which lysophospholipids play a predominant role. The conference site in Ireland will facilitate maximum participation of European scientists, scientists from other countries abroad, and US counterparts to promote productive interactions focusing on the translational implications of lysophospholipids.

抽象的 Faseb科学研究会议上的溶物磷脂和相关介体：从板凳到诊所将于2023年7月9日至7月13日在美国佛罗里达州墨尔本的Crown Plaza Hotel举行。这次会议将解决当前的研究和新兴概念主要与1-磷酸盐的溶血磷脂有关（S1P）和溶物磷脂酸（LPA）及其在健康和疾病中的作用。 S1P和LPA是信号脂质的分别激活5和6 G蛋白偶联受体，并与细胞内靶蛋白结合以调节细胞生物学。这些生物学相互作用控制心血管系统中的重要功能，免疫系统，和神经系统。这些脂质在肺纤维化，动脉粥样硬化，癌症，自身免疫性中很重要，和其他疾病状态。已经显示了调节溶物磷脂代谢的受体和酶充当诊断，预防或治疗疾病的潜在治疗靶标。会议将强调这项工作将这项工作转化为临床实践，并突出了以迅速发展的研究进展在该领域的许多新调查人员中。会议为来自的科学家提供了一个独特而宝贵的论坛各种各样的学科，以见面并讨论他们最新的研究结果。会议的目的是1）提供来自从事溶血磷脂的多个学科的科学家和学员之间的智力交流研究; 2）鼓励和促进早期职业与新调查人员之间的积极讨论以及通过互动职业研讨会和网络/协作的多个机会建立了科学家； 3）提供一个平台来促进妇女和代表性不足的少数民族的参与。会议将允许多样化的早期职业，并建立了调查人员，以交流破裂的研究结果和促进未来的相互作用与开发疾病的疗法一致，其中溶血磷脂发挥了主要作用。爱尔兰的会议地点将促进欧洲科学家的最大参与，来自国外其他国家的科学家和美国的科学家，以促进着重于生产性互动溶物磷脂的翻译意义。