Immune determinants of pediatric HIV/SIV reservoir establishment and maintenance

儿科 HIV/SIV 病毒库建立和维持的免疫决定因素

• 批准号: 10701468
• 负责人: Ann M Chahroudi
• 金额: $ 3.41万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701468
• 关键词: Accountability; Accounting; Achievement; Acquired Immunodeficiency Syndrome; Adherence; Administrative Personnel; Advisory Committees; Animals; Annual Reports; Area; Bioinformatics; Cloud Computing; Collaborations; Communication; Communities; Complement; Computer software; Data; Decision Making; Dedications; Doctor of Philosophy; Documentation; Ensure; Environment; Feedback; Fostering; Funding; Funding Opportunities; Future; Goals; Guidelines; HIV-1; Immune; Infection; Infrastructure; Institution; Lead; Leadership; Maintenance; Manuscripts; Mentors; Monitor; Occupational activity of managing finances; Output; Play; Policies; Preparation; Production; Protocols documentation; Recording of previous events; Regulation; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resource Allocation; Resource Sharing; Resources; Role; SIV; Sampling; Schedule; Services; Site; Specimen; Strategic Planning; Structure; System; United States National Institutes of Health; Universities; Update; Work; biobank; cloud based; data communication; data dissemination; data management; data sharing; meetings; pediatric human immunodeficiency virus; programs; repository; symposium; synergism

ABSTRACT – Administrative Core This proposed Program’s overarching scientific goal is to understand the immune determinants of pediatric HIV reservoir establishment and maintenance. To ensure successful completion of the scientific Aims, the Administrative Core will coordinate oversight of all Program activities, create regulatory and NIH compliance documentation, and manage data and communication. The Core will serve as the Program hub for ensuring adherence to biorepository and institutional animal use policies and for coordinating the transfer of specimens and data. The Core will drive the Program’s focus on regular, consistent communication and will coordinate meetings to ensure extensive integration across Projects and Cores and to solicit feedback from the external Advisory Committee. The Administrative Core will also play a key role in ensuring the mentoring of early-stage investigators (ESIs) in Project Leadership roles, with support from the overall Program PI, Project Co-Leads, and the Emory Center for AIDS Research (CFAR). The Administrative Core will ensure fiscal accountability and proactively identify areas in which funds may need to be reallocated. This will be a key service of the Administrative Core that will help determine study directions in the later years of the project period. This function will be complemented by purposeful engagement of additional funding opportunities and strategic planning for future studies based on the results of the Program. The Administrative Core will also serve as the main contact for financial and data management with the Emory CFAR Cores that will be leveraged in this Program. Finally, the Core will contribute to Program synergy through the use of collaborative, cloud-based software that ensures the results generated across Projects are efficiently communicated and can be easily tracked and updated through the utilization of cloud-based computing outlined in the Bioinformatics Core. Regular maintenance of shared documents, experimental progress, and milestone achievement will allow for timely communication with the scientific community including the production of abstracts and manuscripts. The communication services provided by the Administrative Core will be critical in ensuring the objectives of each Research Project are met and that findings are disseminated to a broad public. By harnessing Emory’s existing research support environment and history of collaboration, this Core will ensure rapid Program start-up, including structure, efficiency, and expertise to support the proposed work.

抽象--管理核心 这一计划的主要科学目标是了解儿童艾滋病毒的免疫决定因素 水库的建立和维护。为确保圆满完成科学目标， 管理核心将协调对所有计划活动的监督，制定法规和NIH合规性 文档，并管理数据和通信。核心将作为计划中心，以确保 遵守生物保存库和机构动物使用政策，并协调标本转让 和数据。核心将推动该计划对定期、一致的沟通的关注，并将协调 召开会议，确保跨项目和核心的广泛整合，并征求外部反馈 咨询委员会。行政核心还将在确保早期指导方面发挥关键作用 项目领导角色中的调查员(ESIS)，在总体计划PI、项目联合领导、 和埃默里艾滋病研究中心(CFAR)。行政核心将确保财政问责 并主动确定可能需要重新分配资金的领域。这将是一项关键的服务 行政核心，将帮助确定项目期后期的研究方向。这 职能将通过有目的地参与其他资金机会和战略活动来补充 根据该计划的结果对未来的研究进行规划。行政核心也将作为 与Emory CFAR核心的财务和数据管理主要联系人 程序。最后，核心将通过使用协作、基于云的 确保跨项目生成的结果得到有效沟通并可以轻松实现的软件 通过利用《生物信息学核心》中概述的云计算进行跟踪和更新。 定期维护共享文档、试验进展和里程碑成就将允许 及时与科学界沟通，包括制作摘要和手稿。这个 行政核心提供的通信服务将是确保每一项目标的关键 满足研究项目，并将研究结果传播给广大公众。通过利用埃默里现有的 研究支持环境和协作历史，这一核心将确保快速启动计划， 包括支持拟议工作的结构、效率和专业知识。