Immune determinants of pediatric HIV/SIV reservoir establishment and maintenance

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ABSTRACT – Administrative Core This proposed Program’s overarching scientific goal is to understand the immune determinants of pediatric HIV reservoir establishment and maintenance. To ensure successful completion of the scientific Aims, the Administrative Core will coordinate oversight of all Program activities, create regulatory and NIH compliance documentation, and manage data and communication. The Core will serve as the Program hub for ensuring adherence to biorepository and institutional animal use policies and for coordinating the transfer of specimens and data. The Core will drive the Program’s focus on regular, consistent communication and will coordinate meetings to ensure extensive integration across Projects and Cores and to solicit feedback from the external Advisory Committee. The Administrative Core will also play a key role in ensuring the mentoring of early-stage investigators (ESIs) in Project Leadership roles, with support from the overall Program PI, Project Co-Leads, and the Emory Center for AIDS Research (CFAR). The Administrative Core will ensure fiscal accountability and proactively identify areas in which funds may need to be reallocated. This will be a key service of the Administrative Core that will help determine study directions in the later years of the project period. This function will be complemented by purposeful engagement of additional funding opportunities and strategic planning for future studies based on the results of the Program. The Administrative Core will also serve as the main contact for financial and data management with the Emory CFAR Cores that will be leveraged in this Program. Finally, the Core will contribute to Program synergy through the use of collaborative, cloud-based software that ensures the results generated across Projects are efficiently communicated and can be easily tracked and updated through the utilization of cloud-based computing outlined in the Bioinformatics Core. Regular maintenance of shared documents, experimental progress, and milestone achievement will allow for timely communication with the scientific community including the production of abstracts and manuscripts. The communication services provided by the Administrative Core will be critical in ensuring the objectives of each Research Project are met and that findings are disseminated to a broad public. By harnessing Emory’s existing research support environment and history of collaboration, this Core will ensure rapid Program start-up, including structure, efficiency, and expertise to support the proposed work.