Development of a Novel Cooling Vest to Prevent Heat-Induced Thermoregulatory Dysfunction in Persons with Spinal Cord Injury
开发新型降温背心以预防脊髓损伤患者因热引起的体温调节功能障碍
基本信息
- 批准号:10701833
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-11-01 至 2024-10-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdverse effectsAffectAttenuatedAutonomic PathwaysBiomedical EngineeringBody TemperatureBrainCervical spinal cord injuryCessation of lifeCollaborationsCompensationCutaneousDevelopmentEffectivenessEnsureEnvironmentEsthesiaExperimental DesignsExposure toFatigueFeedbackFeelingFunctional disorderGoalsHealthHeat ExhaustionHeat LossesHeat Stress DisordersHeat StrokeHeat WavesHomeostasisHourHuman EngineeringHyperthermiaHypothalamic structureImpaired cognitionImpairmentIncreased sweatingInjuryInterruptionInterventionInvestigationLaboratory ResearchLesionLettersLiquid substanceMaintenanceMarketingMeasuresMedicalMethodsMotorNormal RangeOrgan failurePacific NorthwestParticipantPathway interactionsPerceptionPerformancePersonsPhysiologic ThermoregulationPilot ProjectsPositioning AttributeQuadriplegiaQuality of lifeRegulationReligionReportingResearch PersonnelRiskSafetySeasonsSeizuresSensoryShiveringSkin TemperatureSpinal cord injurySpottingsSunlightSweatingTechnology TransferTemperatureTestingThinkingTravelUnconscious StateVasodilationVasomotorVeteransWorkbody systemclimate zonecold injurydesignefficacy evaluationefficacy testingexperiencehome testhot climatehuman subjectimprovedmilitary veterannovelpreventprogramsprototyperecruitsafety testingsocialthoracic vertebra bone structurevasoconstrictionwarm temperature
项目摘要
Persons with spinal cord injury (SCI), particularly those with injuries above T6 (Hi-SCI), are unable to effectively
regulate core body temperature (Tcore) due to interruption of motor, sensory, and sympathetic pathways.
Interruption of sympathetic pathways limits central regulation of vasodilation and sweating for increasing heat
loss and vasoconstriction for decreasing heat loss. Thus, when exposed to ambient heat, limited control of
cutaneous vasodilation and sweating impairs the ability to maintain a constant Tcore. Persons with Hi-SCI often
find themselves in hot environments for prolonged periods during social, religious, or work functions, especially
during warmer seasons or when in hot climate zones. They report rapidly progressing to feeling “overheated,”
uncomfortable, and fatigued during even limited exposure to conditions considered as mildly hot by able-bodied
(AB) controls. During these times, their dramatic rise in Tcore can reach hyperthermia (≥38°C) and, if allowed to
progress, can lead to heat stroke, causing seizures, loss of consciousness, and potentially death. Interventions
that address the increased risk for heat-related illness in persons with SCI are limited. Therefore, continuing
development of our feedback-controlled ”smart” cooling vest and testing its safety and efficacy to sufficiently
dissipate body heat to compensate for thermodysregulation, is absolutely vital to minimize the adverse effects
on health and quality of life that most Veterans with Hi-SCI experience during exposure to warm temperatures.
The goals of this pilot study are to: 1) further develop and test the safety and tolerability of a self-regulating
cooling vest in AB participants, and 2) determine the efficacy of the cooling vest to provide protection from an
excessive rise in Tcore and thermal discomfort during warm exposure in Veterans with Hi-SCI. Five AB
participants and ten participants with Hi-SCI (C4-T2, AIS A-B) will be recruited for study. AB participants will be
observed to ensure the safety of the vest, which will be determined by assessing skin temperatures and
subjective thermal sensation beneath the vest during 2 hours of warm exposure (35°C). In participants with Hi-
SCI during 2 hours of warm exposure (35°C), a repeated measures experimental design for [two-conditions (wet
vest, no vest)] is being proposed to demonstrate the efficacy of the cooling vest to attenuate the expected rise
in Tcore and thermal discomfort.
Primary Objective (Safety): In a warm thermal chamber (35°C), AB participants will wear the wet cooling vest
at maximal setting for 2 hours in the seated position to determine: (1) minimum skin temperatures beneath the
wet cooling vest, and (2) subjective comfort of the wet cooling vest (safety testing).
Primary Hypotheses: AB participants will demonstrate (1) All skin temperatures beneath the vest will be ≥20°C.
(2) All participants will report a thermal sensation (TS) ≥ “cool” (not “cold” or “very cold”) (Zhang 9-point Thermal
Sensation scale).
Secondary Objective (Efficacy in SCI): On 2 separate days, participants with Hi-SCI will wear either the wet
cooling vest [or no vest] (in random order) for up to 2 hours in the seated position in a warm thermal chamber
(35°C) to determine: (1) change in Tcore, and (2) change in thermal comfort (efficacy testing).
Secondary Hypotheses: Participants with Hi-SCI wearing the wet cooling vest when in the warm environment
will have the following findings: 1) 65% will demonstrate a significantly reduced elevation in Tcore (≤0.3°C)
than the expected mean increase (0.6±0.3°C) in the [no vest condition], and 2) a greater percentage of
participants with SCI will report a decreased perception of heat and thermal discomfort (Zhang 6-point Thermal
Comfort scale) than the expected perceptions of “hot or very hot” and “uncomfortable” that will be reported in
the [no vest condition].
脊髓损伤(SCI)的人,特别是T6以上的损伤(Hi-SCI),无法有效地
项目成果
期刊论文数量(0)
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John P Handrakis其他文献
John P Handrakis的其他文献
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{{ truncateString('John P Handrakis', 18)}}的其他基金
Development of a Novel Cooling Vest to Prevent Heat-Induced Thermoregulatory Dysfunction in Persons with Spinal Cord Injury
开发新型降温背心以预防脊髓损伤患者因热引起的体温调节功能障碍
- 批准号:
10585195 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Developing a Feedback-Controlled Heated Vest to Address Thermoregulatory Dysfunction in Persons with Spinal Cord Injury
开发反馈控制加热背心以解决脊髓损伤患者的体温调节功能障碍
- 批准号:
10543979 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Developing a Feedback-Controlled Heated Vest to Address Thermoregulatory Dysfunction in Persons with Spinal Cord Injury
开发反馈控制加热背心以解决脊髓损伤患者的体温调节功能障碍
- 批准号:
10310398 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Developing a Feedback-Controlled Heated Vest to Address Thermoregulatory Dysfunction in Persons with Spinal Cord Injury
开发反馈控制加热背心以解决脊髓损伤患者的体温调节功能障碍
- 批准号:
9816585 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Effect of Heat Exposure on Cognition in Persons with Higher Cord Lesions
热暴露对高位脊髓损伤患者认知的影响
- 批准号:
9067159 - 财政年份:2015
- 资助金额:
-- - 项目类别:
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