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Retinal vasculature in hypertension

高血压患者的视网膜血管

基本信息

批准号：
10701665
负责人：
NORMAN R HARRIS
金额：
$ 36.5万
依托单位：
LOUISIANA STATE UNIV HSC SHREVEPORT
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10701665
关键词：
Address Adhesions Adult Angiotensin II Antihypertensive Agents Area Basement membrane Blood Platelets Blood Pressure Blood Vessels Blood capillaries Blood flow Blood-Retinal Barrier CD31 Antigens Chronic Collagen Connexin 43 Data Dependence Desmin Development Disease E-Selectin Endothelial Cells Endothelin-1 Endothelium Event Extracellular Matrix Eye Female Fibronectins Functional disorder Future Glycocalyx Glycoproteins Glypican Gonadal Steroid Hormones Health Hemorrhage Hypertension Hypertensive Retinopathy Hypoxia Inbred SHR Rats Inbred WKY Rats KDR gene Knowledge Leukocytes Mediator Mesenchymal Microcirculation Modeling Molecular N-Cadherin Names Optic Disk Oxygen Pathologic Pathway interactions Perfusion Pharmaceutical Preparations Phenotype Platelet Glycoproteins Population Predisposition Prevalence Proteoglycan Recovery Retina Retinal Artery Occlusion Retinal Diseases Risk Factors S100A4 gene Smooth Muscle Smooth Muscle Myocytes Surface Swelling Testing Thinness Thrombus United States Vascular Cell Adhesion Molecule-1 Vasodilation Vimentin Vision Work arteriole blood pressure reduction cadherin 5 collagenase cotton wool spots driving force endothelial dysfunction experimental study hypertensive male migration moesin muscle degeneration negative affect normotensive novel optical disc pharmacologic pressure prevent response retina blood vessel structure retina circulation retinal neuron sex syndecan therapeutically effective vein occlusion von Willebrand factor receptor

项目摘要

Approximately 32-44% of the adult US population has hypertension, with one of the many complications being hypertensive retinopathy. In one study, the prevalence of retinopathy was found to be 85% amongst those with severe hypertension, and 25% for those with mild hypertension. Retinal consequences of hypertension include arteriolar narrowing, hemorrhages, cotton wool spots (localized hypoxia), and optic disk swelling. Other retinal changes include hyalinization of arteriolar walls, thickening of the vascular basement membrane, closure of capillaries, smooth muscle degeneration, and blood-retinal barrier dysfunction. Additionally, hypertension is a major risk factor for the highly threatening events of retinal artery or vein occlusion. The primary treatment for hypertensive retinopathy is to reduce blood pressure; however, consequences of the disease including narrowing of arterioles persist even following anti-hypertension medication. Therefore, a better knowledge of the mechanisms of the disease could lead to the development of additional and more effective therapeutic options. Our overall hypothesis is that the vascular complications of hypertensive retinopathy are due phenotypic changes in endothelial and smooth muscle cells, with vessel wall remodeling limiting recovery even with anti-hypertensive medication. The specific aims are to: (1) determine the sex-dependent expression of the glycocalyx in the retina, and determine the consequences of hypertension on this expression, (2) examine the sex-dependent expression of platelet endothelial adhesion molecule-1 and vascular endothelial cadherin in the retina, and test the hypothesis that changes in these junctional molecules in the hypertensive retina are due to endothelial-to- mesenchymal transition, and (3) test the hypothesis that remodeling of blood vessel walls in the SHR retina induces susceptibility to poor retinal perfusion when high blood pressure is reduced to normal.

大约32-44%的美国成年人患有高血压，并伴有多种并发症之一