Mount Sinai Health System Kidney Precision Medicine Project
西奈山卫生系统肾脏精准医学项目
基本信息
- 批准号:10703420
- 负责人:
- 金额:$ 42.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAcuteAcute Renal Failure with Renal Papillary NecrosisAddressAgingAmericanApolipoproteinsBiologicalBiological AssayBiopsyBlood BanksCOVID-19COVID-19 pandemicCOVID-19 patientCaringChronic Kidney FailureClinicClinicalClinical DataClinical ResearchCocaCommunitiesCommunity OutreachComplicationConsentCountryDNADataDedicationsDevelopmentDiabetes MellitusDiabetic NephropathyDialysis procedureDiseaseDisease MarkerDisease ProgressionDocumentationElectronic Health RecordEnrollmentEthicistsEthicsEthnic OriginFinancial HardshipFutureHealthHealth systemHealthcareHemorrhageHospitalizationHumanHypertensionImageIndividualInfrastructureInjuryInstitutionKidneyKidney DiseasesKidney TransplantationLinkMeasurementMolecularMorbidity - disease rateNational Institute of Diabetes and Digestive and Kidney DiseasesObesityOutcomeParticipantPathway interactionsPatientsPhenotypePlasmaProteomicsPublic HealthRaceRecontactsRegistriesRenal functionResearchResourcesRiskSafetySamplingServicesSiteSpecimenSystemTimeTissuesUrinebiobankclinical databasecohortcomorbiditycoronavirus diseasedisorder subtypeethnic diversityethnic minorityexome sequencingexperiencefollow-upgenome sequencinghigh riskhigh standardhuman tissueinnovationkidney biopsymachine learning algorithmmetabolomicsminimal riskmortalitymultidisciplinarymultiple omicsnew therapeutic targetnovelnovel strategiesparticipant enrollmentpatient orientedpatient populationpatient retentionphenotypic datapost SARS-CoV-2 infectionpost-COVID-19precision medicinepredictive toolsprognosticationprogramsracial minorityrecruitresponserisk predictionrisk stratificationsociodemographicstargeted treatmenttherapeutic targettherapy developmenttooltranscriptome sequencingwhole genome
项目摘要
Project Summary
Forty million Americans live with kidney disease and this number is projected to increase with rising rates of
CKD comorbid conditions, including diabetes, obesity, and hypertension, superimposed on an aging patient
population. A tremendous financial burden is imparted by dialysis therapy and kidney transplantation for end-
stage CKD. At present, however, there are limited tools in existence to predict the progression of AKI and
CKD, and development of therapies has been disappointingly restricted. The overall objective of this
application is to establish the Mount Sinai Kidney Precision Medicine Project (KPMP) recruitment site in
support of the larger consortium’s tissue interrogation and phenotyping activities. There is a tremendous need
to utilize human kidney tissue as a research tool for the identification of AKI and CKD disease markers to
elucidate molecular pathways that contribute to kidney disease development and progression. We have
proposed three Specific Aims: Aim 1 will establish a robust system of patient centered oversight to recruit
diverse patients into a kidney biopsy cohort while maintaining the highest standards of safety, quality and
ethical research conduct. In Aim 2 we will recruit and retain a spectrum of patients with CKD in response to
KPMP priorities. This includes leveraging existing institutional risk stratification tools and resources to identify
and recall patients at risk for CKD progression due to diabetes, hypertension, prior COVID-19 infection and
apolipoprotein L1 associated disease. Aim 3 will recruit and retain patients with AKI as well as those at high
risk for AKI identified by a machine learning algorithm. These Aims overseen by a stakeholder board and
executed by an experienced multidisciplinary team, will integrate with the KPMP consortium to accomplish its
transformative aims.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Kirk N Campbell', 18)}}的其他基金
Mount Sinai Health System Kidney Precision Medicine Project
西奈山卫生系统肾脏精准医学项目
- 批准号:
10493649 - 财政年份:2022
- 资助金额:
$ 42.5万 - 项目类别:
Hippo-YAP in podocyte health and disease
Hippo-YAP 在足细胞健康和疾病中的作用
- 批准号:
10618369 - 财政年份:2019
- 资助金额:
$ 42.5万 - 项目类别:
Hippo-YAP in podocyte health and disease
Hippo-YAP 在足细胞健康和疾病中的作用
- 批准号:
9917038 - 财政年份:2019
- 资助金额:
$ 42.5万 - 项目类别:
Hippo-YAP in podocyte health and disease
Hippo-YAP 在足细胞健康和疾病中的作用
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10433862 - 财政年份:2019
- 资助金额:
$ 42.5万 - 项目类别:
Hippo-YAP in podocyte health and disease
Hippo-YAP 在足细胞健康和疾病中的作用
- 批准号:
10188524 - 财政年份:2019
- 资助金额:
$ 42.5万 - 项目类别:
Hippo-YAP in podocyte health and disease
Hippo-YAP 在足细胞健康和疾病中的作用
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10006878 - 财政年份:2019
- 资助金额:
$ 42.5万 - 项目类别:
The role of dendrin in glomerular disease progression
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- 批准号:
9344584 - 财政年份:2015
- 资助金额:
$ 42.5万 - 项目类别:
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