Mount Sinai Health System Kidney Precision Medicine Project

西奈山卫生系统肾脏精准医学项目

基本信息

批准号：
10703420
负责人：
Kirk N Campbell
金额：
$ 42.5万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10703420
关键词：
Acceleration Acute Acute Renal Failure with Renal Papillary Necrosis Address Aging American Apolipoproteins Biological Biological Assay Biopsy Blood Banks COVID-19 COVID-19 pandemic COVID-19 patient Caring Chronic Kidney Failure Clinic Clinical Clinical Data Clinical Research Coca Communities Community Outreach Complication Consent Country DNA Data Dedications Development Diabetes Mellitus Diabetic Nephropathy Dialysis procedure Disease Disease Marker Disease Progression Documentation Electronic Health Record Enrollment Ethicists Ethics Ethnic Origin Financial Hardship Future Health Health system Healthcare Hemorrhage Hospitalization Human Hypertension Image Individual Infrastructure Injury Institution Kidney Kidney Diseases Kidney Transplantation Link Measurement Molecular Morbidity - disease rate National Institute of Diabetes and Digestive and Kidney Diseases Obesity Outcome Participant Pathway interactions Patients Phenotype Plasma Proteomics Public Health Race Recontacts Registries Renal function Research Resources Risk Safety Sampling Services Site Specimen System Time Tissues Urine biobank clinical database cohort comorbidity coronavirus disease disorder subtype ethnic diversity ethnic minority exome sequencing experience follow-up genome sequencing high risk high standard human tissue innovation kidney biopsy machine learning algorithm metabolomics minimal risk mortality multidisciplinary multiple omics new therapeutic target novel novel strategies participant enrollment patient oriented patient population patient retention phenotypic data post SARS-CoV-2 infection post-COVID-19 precision medicine predictive tools prognostication programs racial minority recruit response risk prediction risk stratification sociodemographics targeted treatment therapeutic target therapy development tool transcriptome sequencing whole genome

项目摘要

Project Summary Forty million Americans live with kidney disease and this number is projected to increase with rising rates of CKD comorbid conditions, including diabetes, obesity, and hypertension, superimposed on an aging patient population. A tremendous financial burden is imparted by dialysis therapy and kidney transplantation for end- stage CKD. At present, however, there are limited tools in existence to predict the progression of AKI and CKD, and development of therapies has been disappointingly restricted. The overall objective of this application is to establish the Mount Sinai Kidney Precision Medicine Project (KPMP) recruitment site in support of the larger consortium’s tissue interrogation and phenotyping activities. There is a tremendous need to utilize human kidney tissue as a research tool for the identification of AKI and CKD disease markers to elucidate molecular pathways that contribute to kidney disease development and progression. We have proposed three Specific Aims: Aim 1 will establish a robust system of patient centered oversight to recruit diverse patients into a kidney biopsy cohort while maintaining the highest standards of safety, quality and ethical research conduct. In Aim 2 we will recruit and retain a spectrum of patients with CKD in response to KPMP priorities. This includes leveraging existing institutional risk stratification tools and resources to identify and recall patients at risk for CKD progression due to diabetes, hypertension, prior COVID-19 infection and apolipoprotein L1 associated disease. Aim 3 will recruit and retain patients with AKI as well as those at high risk for AKI identified by a machine learning algorithm. These Aims overseen by a stakeholder board and executed by an experienced multidisciplinary team, will integrate with the KPMP consortium to accomplish its transformative aims.

项目摘要有400万美国人患有肾脏疾病，预计这一数字将随着增加的速度增加 CKD合并症疾病，包括糖尿病，肥胖和高血压，叠加在老年患者身上人口。透析治疗和肾脏移植以最终的方式赋予了巨大的金融伯恩伯恩 CKD阶段。然而，目前存在有限的工具来预测AKI和 CKD和疗法的发展受到令人失望的限制。总体目标应用是在建立西奈山肾脏精密医学项目（KPMP）招聘网站支持较大的财团组织审讯和表型活动。有很大的需求利用人类肾脏组织作为鉴定AKI和CKD疾病标志物的研究工具阐明有助于肾脏疾病发展和进展的分子途径。我们有拟议的三个具体目标：AIM 1将建立一个以患者为中心的监督的强大系统以招募潜水患者进入肾脏活检队列，同时保持最高的安全性，质量和道德研究行为。在AIM 2中，我们将招募并保留一系列CKD患者 KPMP优先级。这包括利用现有的机构风险分层工具和资源来识别并回忆起由于糖尿病，高血压，先前的COVID-19感染而导致CKD进展风险的患者载脂蛋白L1相关疾病。 AIM 3将招募和保留AKI的患者以及高的患者通过机器学习算法确定的AKI风险。这些目标是由利益相关者委员会监督的由经验丰富的多学科团队执行的变革性的目标。