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Mount Sinai Health System Kidney Precision Medicine Project

西奈山卫生系统肾脏精准医学项目

基本信息

批准号：
10703420
负责人：
Kirk N Campbell
金额：
$ 42.5万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10703420
关键词：
Acceleration Acute Acute Renal Failure with Renal Papillary Necrosis Address Aging American Apolipoproteins Biological Biological Assay Biopsy Blood Banks COVID-19 COVID-19 pandemic COVID-19 patient Caring Chronic Kidney Failure Clinic Clinical Clinical Data Clinical Research Coca Communities Community Outreach Complication Consent Country DNA Data Dedications Development Diabetes Mellitus Diabetic Nephropathy Dialysis procedure Disease Disease Marker Disease Progression Documentation Electronic Health Record Enrollment Ethicists Ethics Ethnic Origin Financial Hardship Future Health Health system Healthcare Hemorrhage Hospitalization Human Hypertension Image Individual Infrastructure Injury Institution Kidney Kidney Diseases Kidney Transplantation Link Measurement Molecular Morbidity - disease rate National Institute of Diabetes and Digestive and Kidney Diseases Obesity Outcome Participant Pathway interactions Patients Phenotype Plasma Proteomics Public Health Race Recontacts Registries Renal function Research Resources Risk Safety Sampling Services Site Specimen System Time Tissues Urine biobank clinical database cohort comorbidity coronavirus disease disorder subtype ethnic diversity ethnic minority exome sequencing experience follow-up genome sequencing high risk high standard human tissue innovation kidney biopsy machine learning algorithm metabolomics minimal risk mortality multidisciplinary multiple omics new therapeutic target novel novel strategies participant enrollment patient oriented patient population patient retention phenotypic data post SARS-CoV-2 infection post-COVID-19 precision medicine predictive tools prognostication programs racial minority recruit response risk prediction risk stratification sociodemographics targeted treatment therapeutic target therapy development tool transcriptome sequencing whole genome

项目摘要

Project Summary Forty million Americans live with kidney disease and this number is projected to increase with rising rates of CKD comorbid conditions, including diabetes, obesity, and hypertension, superimposed on an aging patient population. A tremendous financial burden is imparted by dialysis therapy and kidney transplantation for end- stage CKD. At present, however, there are limited tools in existence to predict the progression of AKI and CKD, and development of therapies has been disappointingly restricted. The overall objective of this application is to establish the Mount Sinai Kidney Precision Medicine Project (KPMP) recruitment site in support of the larger consortium’s tissue interrogation and phenotyping activities. There is a tremendous need to utilize human kidney tissue as a research tool for the identification of AKI and CKD disease markers to elucidate molecular pathways that contribute to kidney disease development and progression. We have proposed three Specific Aims: Aim 1 will establish a robust system of patient centered oversight to recruit diverse patients into a kidney biopsy cohort while maintaining the highest standards of safety, quality and ethical research conduct. In Aim 2 we will recruit and retain a spectrum of patients with CKD in response to KPMP priorities. This includes leveraging existing institutional risk stratification tools and resources to identify and recall patients at risk for CKD progression due to diabetes, hypertension, prior COVID-19 infection and apolipoprotein L1 associated disease. Aim 3 will recruit and retain patients with AKI as well as those at high risk for AKI identified by a machine learning algorithm. These Aims overseen by a stakeholder board and executed by an experienced multidisciplinary team, will integrate with the KPMP consortium to accomplish its transformative aims.

项目总结