A prospective study of heat exposure and miscarriage
热暴露和流产的前瞻性研究
基本信息
- 批准号:10701681
- 负责人:
- 金额:$ 21.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-10 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAmerican College of Obstetricians and GynecologistsBehavior TherapyBiologicalBirthBlood flowBudgetsCanadaCharacteristicsClinicalClinical Practice GuidelineCohort StudiesConceptionsConsensusCouplesDataDevelopmentDietEmergency SituationEnrollmentEnvironmentEnvironmental ExposureEtiologyEventExposure toFemaleFetal healthFrequenciesFundingGeographyGreen spaceHealthHomeHouseholdHousingHumanIncomeIndividualInfrastructureInterventionKnowledgeLong-Term EffectsLow Birth Weight InfantMeasurementMeasuresMediatingMicroclimateMonitorMorbidity - disease rateNational Institute of Environmental Health SciencesNeighborhoodsOnline SystemsOutcomeOzoneParticipantPatternPerfusionPersonsPhysical environmentPhysiologicalPlacentaPopulationPopulation DensityPre-EclampsiaPredictive FactorPredispositionPregnancyPregnancy TestsPregnancy lossPregnant WomenPremature BirthProspective StudiesProvinceQuestionnairesRaceReproductionResearchResearch DesignRiskRisk AssessmentRisk FactorsRisk ReductionRoleSample SizeShapesSmokingSpontaneous abortionTemperatureTimeUnited StatesUrineWeatherWomanWomen&aposs HealthWorkadverse pregnancy outcomebuilt environmentclimate changeclimate zoneclimate-related healthcohortearly pregnancyexperienceextreme heatextreme temperatureextreme weatherheat islandhigh riskimprovedinsightlifestyle factorsneonatal outcomeparent grantpeople of colorperinatal healthpredictive modelingpregnancy hypertensionpregnantprospectivepsychologicrecruitreproductivereproductive epidemiologyreproductive outcomesocioeconomicsstillbirthteratogenesistrying to conceivewearable monitorweather stations
项目摘要
ABSTRACT
Given the scientific consensus regarding the role of climate change in causing increased temperatures and
higher frequency of extreme weather events in the coming decades, it is crucial to clarify the effects of climate
change on human reproduction. A substantial body of research has documented that exposure to heat is
associated with adverse pregnancy and neonatal outcomes, including preeclampsia, gestational hypertension,
low birth weight, and preterm birth. However, there has been limited assessment of the association between
ambient heat and spontaneous abortion (SAB), defined as a pregnancy loss before 20 weeks’ gestation. SAB
is a particularly challenging reproductive event to measure because many SABs occur early in gestation, often
before pregnancy recognition. The ideal study design for accurately measuring SAB is a preconception cohort
where early reproductive events are closely monitored. In addition, most research on the health effects of heat
have measured ambient rather than personal temperature exposure, despite the fact that ambient temperature
does not sufficiently represent the environmental conditions individuals experience as they move throughout
time and space. In the present proposal, we will utilize the infrastructure of an ongoing preconception cohort
study, Pregnancy Study Online (PRESTO), to explore the role of ambient and personal heat exposure in the
etiology of SAB. PRESTO has successfully enrolled a geographically, racially, and socioeconomically diverse
cohort of couples trying to conceive from across the United States and Canada, and using these data, we have
prospectively identified SAB, including early SAB (<6 weeks’ gestation), and assessed risk factors for SAB.
Specifically, in the present proposal, we aim to 1) examine the association between ambient heat and SAB risk
and measure the extent to which select geospatial features mediate or modify this association, and 2) deploy
wearable personal temperature monitors for one week among 400 newly-enrolled female PRESTO participants
and use monitoring data to identify geospatial, neighborhood, and individual-level predictors of heat exposure.
The proposed study will have a large and sustained impact on the fields of reproductive epidemiology and
climate health. This will be the first study to measure personal exposure to heat in pregnant women, a
population with underlying physiologic susceptibility to heat. Our predictive models of heat exposure have vast
applications in fields of environmental exposure assessment. The ability to measure personal heat exposure
using questionnaire and geospatial data, rather than relying on personal monitoring, could revolutionize the
study of the health effects of extreme temperatures. In addition, this study could provide critical information on
the etiology of SAB, inform specific interventions to reduce SAB risk, and challenge current clinical practice
guidelines for advising women early in pregnancy that focus on lifestyle factors such as smoking and diet.
Finally, we seek to shift current research paradigms by advancing knowledge on the role of climate change in
shaping reproductive outcomes.
摘要
项目成果
期刊论文数量(0)
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Amelia Kent Wesselink其他文献
Amelia Kent Wesselink的其他文献
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{{ truncateString('Amelia Kent Wesselink', 18)}}的其他基金
An assessment of environmental and neighborhood-level risk factors for subfertility among Black women in the U.S.
对美国黑人女性生育力低下的环境和社区风险因素的评估
- 批准号:
10636026 - 财政年份:2023
- 资助金额:
$ 21.6万 - 项目类别:
A prospective study of heat exposure and miscarriage
热暴露和流产的前瞻性研究
- 批准号:
10452143 - 财政年份:2022
- 资助金额:
$ 21.6万 - 项目类别:
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- 批准号:
8849159 - 财政年份:2014
- 资助金额:
$ 21.6万 - 项目类别: