Nest#2-Sensor Withdrawn from A Remote Module (SWARM)

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• 批准号: 10701816
• 负责人: Nathaniel Steven Makowski
• 金额: $ 51.92万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-10 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701816
• 关键词: Ankle; Cerebral Palsy; Clinical; Communication; Communities; Computer software; Data; Development; Distal; Documentation; Ecosystem; Electromagnetics; Electronics; Equilibrium; Extravasation; Failure; Feasibility Studies; Feedback; Future; Gait; Goals; Hand; Health; Heart; Heel; Human; Implant; Limb structure; Location; Lung; Measurement; Measures; Monitor; Movement; Organ; Output; Paralysed; Pathway interactions; Persons; Positioning Attribute; Process; Protocols documentation; Quality of life; Research; Research Support; Signal Transduction; Spinal cord injury; Stomach; Stroke; System; Testing; Walking; analog; design; detection method; digital; electronic sensor; foot; human subject; implanted sensor; improved; improved mobility; interoperability; open source; sensor; translation to humans

The goal of this Nest is to facilitate research teams’ development and implementation of implantable sensors. Many research teams developing specialized sensors do not have the expertise in-house to develop human grade implants and to transition to testing in human subjects. As part of the Cleveland Open Source Modular Interoperable Implantable Community (COSMIIC), we will simplify and streamline this process for research groups by developing the Sensor Withdrawn from A Remote Module (SWARM). The SWARM System consists of a sensor agnostic module, the SWARM Host, that will communicate with an arbitrary outlying sensor, the SWARM Sensor, based on the clinical need and targeted function. As part of the COSMIIC ecosystem, teams can take advantage of the SWARM Host, power module (PM), and all of the other NNP platform hardware and software protocols, and focus development on a new SWARM sensor for internal health monitoring or other applications. Incorporating stimulation modules will enable closed loop control when clinically appropriate. This project will thereby enhance the development process for other teams and enable more rapid implementation in people with clinical needs. In addition to facilitating development, the proposed modularity enables sensor placement in locations of the body that would be impractical for a full remote module. For example, sensors could be placed in the distal extremities to measure foot and hand movement to support feedback control. Alternatively, sensors could be placed deeper into the body, on the heart, lungs, stomach, or other organs as part of an implanted system regulating autonomic function. This project will develop the SWARM Host and a single SWARM Sensor as a proof of concept. The SWARM Host will utilize the same packaging as existing remote modules, minimizing additional development. In this instance, an inertial measurement unit (IMU) will be implemented as the SWARM Sensor; however, the communication and powering protocols will enable the SWARM Host to receive digital or analog signals from a wide variety of sensors in the future so that the module can be used for many applications. The following Aims will facilitate translation to human users: Aim 1: Develop SWARM Host circuitry for communication with outlying sensors and integrate into a full module. Aim 2: Design and fabricate a SWARM IMU Sensor as a proof-of-concept. Aim 3: Complete bench-top testing for a full SWARM System to generate data for an early feasibility study IDE submission. This project will generate the SWARM System consisting of the Host and sensor. The documentation will create a pathway for other teams to develop sensors to integrate with the SWARM System. The open- source material will enable the COSMIIC community to implement new sensors that amplify potential clinical needs that could be met with the NNP system and then become products to improve quality of life for people.

该 Nest 的目标是促进研究团队开发和实施植入式 传感器。许多开发专用传感器的研究团队没有内部开发专业知识 人类级植入物并过渡到人体测试。作为克利夫兰开源项目的一部分 模块化互操作植入社区（COSMIIC），我们将简化这一流程 研究小组开发了从远程模块中取出的传感器（SWARM）。蜂群 系统由一个与传感器无关的模块（即 SWARM 主机）组成，它将与任意传感器进行通信 外围传感器，即基于临床需求和目标功能的 SWARM 传感器。作为 COSMIIC 的一部分 生态系统，团队可以利用 SWARM 主机、电源模块 (PM) 和所有其他 NNP 平台硬件和软件协议，并重点开发用于内部健康的新型 SWARM 传感器 监控或其他应用程序。结合刺激模块将在以下情况下实现闭环控制： 临床上合适。因此，该项目将增强其他团队的开发流程，并使 在有临床需求的人群中更快速地实施。 除了促进开发之外，所提出的模块化还可以将传感器放置在适当的位置 这对于完整的远程模块来说是不切实际的。例如，传感器可以放置在 四肢远端测量脚和手的运动以支持反馈控制。或者，传感器 作为植入物的一部分，可以被放置在身体更深处，心脏、肺、胃或其他器官上 调节自主功能的系统。 该项目将开发 SWARM 主机和单个 SWARM 传感器作为概念验证。这 SWARM Host 将使用与现有远程模块相同的封装，从而最大限度地减少额外的开发。 在这种情况下，惯性测量单元（IMU）将被实现为群传感器；然而， 通信和供电协议将使 SWARM 主机能够从 未来传感器种类繁多，使该模块可用于多种应用。以下目标 将有助于向人类用户进行翻译：目标 1：开发 SWARM 主机电路以与 外围传感器并集成到一个完整的模块中。目标 2：设计并制造一个 SWARM IMU 传感器作为 概念验证。目标 3：对完整的 SWARM 系统进行完整的台式测试，以生成早期数据 可行性研究 IDE 提交。 该项目将生成由主机和传感器组成的 SWARM 系统。文档 将为其他团队开发与 SWARM 系统集成的传感器创造一条途径。开放式 源材料将使 COSMIIC 社区能够实施新的传感器，以放大潜在的临床 NNP系统可以满足这些需求，然后成为改善人们生活质量的产品。