Nest#2-Sensor Withdrawn from A Remote Module (SWARM)

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• 批准号: 10701816
• 负责人: Nathaniel Steven Makowski
• 金额: $ 51.92万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-10 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701816
• 关键词: Ankle; Cerebral Palsy; Clinical; Communication; Communities; Computer software; Data; Development; Distal; Documentation; Ecosystem; Electromagnetics; Electronics; Equilibrium; Extravasation; Failure; Feasibility Studies; Feedback; Future; Gait; Goals; Hand; Health; Heart; Heel; Human; Implant; Limb structure; Location; Lung; Measurement; Measures; Monitor; Movement; Organ; Output; Paralysed; Pathway interactions; Persons; Positioning Attribute; Process; Protocols documentation; Quality of life; Research; Research Support; Signal Transduction; Spinal cord injury; Stomach; Stroke; System; Testing; Walking; analog; design; detection method; digital; electronic sensor; foot; human subject; implanted sensor; improved; improved mobility; interoperability; open source; sensor; translation to humans

The goal of this Nest is to facilitate research teams’ development and implementation of implantable sensors. Many research teams developing specialized sensors do not have the expertise in-house to develop human grade implants and to transition to testing in human subjects. As part of the Cleveland Open Source Modular Interoperable Implantable Community (COSMIIC), we will simplify and streamline this process for research groups by developing the Sensor Withdrawn from A Remote Module (SWARM). The SWARM System consists of a sensor agnostic module, the SWARM Host, that will communicate with an arbitrary outlying sensor, the SWARM Sensor, based on the clinical need and targeted function. As part of the COSMIIC ecosystem, teams can take advantage of the SWARM Host, power module (PM), and all of the other NNP platform hardware and software protocols, and focus development on a new SWARM sensor for internal health monitoring or other applications. Incorporating stimulation modules will enable closed loop control when clinically appropriate. This project will thereby enhance the development process for other teams and enable more rapid implementation in people with clinical needs. In addition to facilitating development, the proposed modularity enables sensor placement in locations of the body that would be impractical for a full remote module. For example, sensors could be placed in the distal extremities to measure foot and hand movement to support feedback control. Alternatively, sensors could be placed deeper into the body, on the heart, lungs, stomach, or other organs as part of an implanted system regulating autonomic function. This project will develop the SWARM Host and a single SWARM Sensor as a proof of concept. The SWARM Host will utilize the same packaging as existing remote modules, minimizing additional development. In this instance, an inertial measurement unit (IMU) will be implemented as the SWARM Sensor; however, the communication and powering protocols will enable the SWARM Host to receive digital or analog signals from a wide variety of sensors in the future so that the module can be used for many applications. The following Aims will facilitate translation to human users: Aim 1: Develop SWARM Host circuitry for communication with outlying sensors and integrate into a full module. Aim 2: Design and fabricate a SWARM IMU Sensor as a proof-of-concept. Aim 3: Complete bench-top testing for a full SWARM System to generate data for an early feasibility study IDE submission. This project will generate the SWARM System consisting of the Host and sensor. The documentation will create a pathway for other teams to develop sensors to integrate with the SWARM System. The open- source material will enable the COSMIIC community to implement new sensors that amplify potential clinical needs that could be met with the NNP system and then become products to improve quality of life for people.

这个Nest的目标是促进研究团队开发和实施植入式 传感器.许多开发专用传感器的研究团队没有内部专业知识来开发 人类级植入物，并过渡到在人类受试者中进行测试。作为克利夫兰开源的一部分， 模块化互操作植入式社区（COSMIIC），我们将简化和精简这一过程， 传感器从远程模块撤回（SWARM）。虫群 系统由一个传感器不可知模块（SWARM主机）组成，该模块将与任意 基于临床需求和目标功能，我们开发了一种外围传感器，即SWARM传感器。作为宇宙的一部分， 生态系统，团队可以利用SWARM主机，电源模块（PM）和所有其他NNP 平台的硬件和软件协议，并专注于开发一种新的SWARM传感器的内部健康 监控或其他应用。在以下情况下，激活刺激模块将启用闭环控制： 临床上合适的。因此，该项目将增强其他团队的开发过程， 在有临床需求的人群中更快速地实施。 除了促进开发外，所提出的模块化还使传感器能够放置在 这对于一个完整的远程模块来说是不切实际的。例如，传感器可以放置在 远端四肢测量脚和手的运动，以支持反馈控制。或者，传感器 可以被放置在身体更深处，在心脏，肺，胃或其他器官上，作为植入的一部分。 调节自主功能的系统。 该项目将开发SWARM主机和单个SWARM传感器作为概念验证。的 SWARM主机将使用与现有远程模块相同的包装，最大限度地减少额外的开发。 在这种情况下，惯性测量单元（IMU）将被实现为SWARM传感器;然而， 通信和供电协议将使SWARM主机能够从 在未来的各种传感器，使该模块可以用于许多应用。以下目标 目标1：开发SWARM主机电路，用于与 外围传感器并集成到完整模块中。目标2：设计和制造SWARM IMU传感器， 概念验证目标3：完成完整SWARM系统的实验室测试，以生成早期 可行性研究IDE提交。 该项目将生成由主机和传感器组成的SWARM系统。的文件 将为其他团队开发与SWARM系统集成的传感器创造一条途径。公开赛- 源材料将使COSMIIC社区能够实现新的传感器， 这些需求可以通过NNP系统得到满足，然后成为改善人们生活质量的产品。