eMOM: enhanced Monitoring to Optimize Maternal Diabetes detection
eMOM:增强监测以优化孕产妇糖尿病检测
基本信息
- 批准号:10701660
- 负责人:
- 金额:$ 32.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-20 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:Adverse eventAffectAgeBeta CellBiological AssayBiological MarkersBirth traumaBlindedBody mass indexC-PeptideCalibrationCell DeathChildhoodContinuous Glucose MonitorDataData CollectionDetectionDevelopmentDiagnosisDystociaEarly DiagnosisEarly treatmentEligibility DeterminationEthnic OriginFingersFirst Pregnancy TrimesterFollow-Up StudiesFrequenciesFunctional disorderFundingGenerationsGestational AgeGestational DiabetesGlucagonGlucoseHourHypoglycemiaIndividualInfantInsulinInsulin ResistanceKnowledgeLeptinMaternal AgeMaternal complicationMeasurementMetabolicMethodsMonitorMothersNon-Insulin-Dependent Diabetes MellitusOGTTObservational StudyOutcomeParticipantPatternPerformancePhysiologicalPlasmaPostpartum PeriodPre-EclampsiaPregnancyPregnancy TrimestersPregnant WomenProcessRaceRecommendationRiskRisk FactorsSample SizeSecond Pregnancy TrimesterShoulderSpontaneous abortionSubgroupTestingThird Pregnancy TrimesterTimeVariantVisitWeight GainWomanadiponectinadverse maternal outcomesadverse pregnancy outcomecohortcongenital anomalyglucose sensorglycationhigh riskimprovedinsulin sensitivityintrauterine environmentmaternal diabetesmaternal outcomematernal weightmetabolic abnormality assessmentmetabolic profilemonitoring deviceneonatal outcomenon-diabeticoffspringoutcome predictionparityperinatal outcomesprepregnancyprospectivescreeningstandard of carestillbirththerapy outcome
项目摘要
Project Summary/Abstract
Over 250,000 women develop gestational diabetes mellitus (GDM) each year in the U.S,
affecting 6.4% of all pregnancies. Current methods for the diagnosis of GDM are not conducted
until the end of the second or early in the third trimester; however, it is possible dysglycemia
leading to both adverse maternal and neonatal outcomes are present well before this gold
standard screening. With the newest generation of continuous glucose monitors (CGM), the
ability to collect accurate data that does not require fingerstick calibration and can be
comfortably worn long enough to capture glucose dynamics is now feasible. The present
proposal seeks to longitudinally assess glycemia in healthy, non-diabetic pregnant women by
using blinded CGM data collection in 4-week intervals beginning between 6-12 weeks’
gestation. These data will allow for determination if a difference in mean sensor glucose levels
exists between women who develop GDM vs. those who do not using standard of care oral
glucose tolerance test (OGTT) screening. Furthermore, with the frequency of CGM data
collection, the optimal time to first detect the difference in mean sensor glucose levels can be
explored. Finally, more rigorous OGTTs will be conducted allowing for assessment of the
metabolic abnormalities that underlie the diagnosis of GDM including whether the dysglycemia
is due to insulin resistance or β-cell dysfunction. With the use of a consortium to conduct the
present study, a large cohort is feasible which will allow for assessment of factors that may
contribute to risk of dysglycemia and GDM, including race/ethnicity, pre-pregnancy BMI,
maternal age, parity and weight gain during pregnancy. The findings of this study may provide
a paradigm shift in how we diagnose GDM if blinded CGM can be used in place of an OGTT
and understanding of the metabolic alterations that lead to diagnosis of GDM.
项目摘要/摘要
在美国,每年有超过25万名妇女患上妊娠期糖尿病(GDM),
影响6.4%的怀孕。目前诊断妊娠期糖尿病的方法还没有进行。
直到第二个月末或第三个月初;然而,它可能是血糖异常
导致母亲和新生儿的不良结局早在这个黄金出现之前就已经出现了
标准筛查。凭借最新一代的连续血糖监测仪(CGM),
能够收集准确的数据,不需要手指棒校准,并且可以
舒适的佩戴足够长的时间来捕捉血糖动态现在是可行的。现在
该提案寻求通过以下方式纵向评估健康、非糖尿病孕妇的血糖
使用盲法CGM数据收集,从6-12周开始,间隔4周
怀孕了。这些数据将允许确定传感器平均血糖水平的差异
患有妊娠期糖尿病的女性与不使用标准口腔护理的女性之间存在差异
糖耐量试验(OGTT)筛选。此外,随着CGM数据的频率
收集时,首先检测平均传感器血糖水平差异的最佳时间可以是
探索过了。最后,将进行更严格的OGTT,以评估
代谢异常是诊断妊娠期糖尿病的基础,包括血糖异常是否
是由于胰岛素抵抗或β细胞功能障碍。利用一个财团进行
目前的研究,一个大的队列是可行的,这将允许评估可能
导致血糖紊乱和妊娠期糖尿病的风险,包括种族/民族、孕前体重指数、
孕妇的年龄、产次和孕期体重增加。这项研究的发现可能会提供
如果盲目的CGM可以取代OGTT,我们诊断GDM的方式将发生范式转变
以及对导致诊断妊娠期糖尿病的代谢变化的了解。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Audrey Merriam其他文献
Audrey Merriam的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Audrey Merriam', 18)}}的其他基金
eMOM: enhanced Monitoring to Optimize Maternal Diabetes detection
eMOM:增强监测以优化孕产妇糖尿病检测
- 批准号:
10227762 - 财政年份:2019
- 资助金额:
$ 32.33万 - 项目类别:
eMOM: enhanced Monitoring to Optimize Maternal Diabetes detection
eMOM:增强监测以优化孕产妇糖尿病检测
- 批准号:
10021648 - 财政年份:2019
- 资助金额:
$ 32.33万 - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
$ 32.33万 - 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
- 批准号:
2601817 - 财政年份:2021
- 资助金额:
$ 32.33万 - 项目类别:
Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
- 批准号:
2029039 - 财政年份:2020
- 资助金额:
$ 32.33万 - 项目类别:
Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
- 批准号:
9888417 - 财政年份:2019
- 资助金额:
$ 32.33万 - 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
- 批准号:
17K11318 - 财政年份:2017
- 资助金额:
$ 32.33万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
$ 32.33万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
$ 32.33万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
$ 32.33万 - 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
- 批准号:
BB/M50306X/1 - 财政年份:2014
- 资助金额:
$ 32.33万 - 项目类别:
Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
- 批准号:
288272 - 财政年份:2013
- 资助金额:
$ 32.33万 - 项目类别:
Miscellaneous Programs