Maternal Fetal Medicine Units Network: University of California, San Francisco

母胎医学单位网络：加州大学旧金山分校

• 批准号: 10682872
• 负责人: MARY E NORTON
• 金额: $ 35.53万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682872
• 关键词: Area; Attention; Basic Science; Birth; Black race; COVID-19 impact; COVID-19 pandemic; California; Caring; Clinic; Clinical; Clinical Research; Clinical Services; Clinical Trials; Collection; Comprehensive Health Care; Conscious; DNA; Diabetes Mellitus; Disparity; Education; Endocrinology; Enrollment; Ensure; Environment; Environmental Impact; Environmental Pollutants; Epigenetic Process; Equity; Ethnic Origin; Ethnic Population; Fetal Growth; Gender Identity; General Hospitals; Genetic; Genomics; Goals; Health system; Heart Diseases; Hospitals; Hypertension; Individual; Infant; Infection; Infrastructure; Intervention; Lactation; Maternal Mortality; Maternal complication; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Metagenomics; Methodology; Mission; Molecular; Morbidity - disease rate; Multi-Institutional Clinical Trial; Multicenter Trials; Neurology; Newborn Infant; Outcome; Outpatients; Participant; Patients; Perinatal; Perinatal Care; Persons; Pharmacogenomics; Placental Biology; Plasma; Population; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Prenatal Diagnosis; Public Health; Race; Recruitment Activity; Reproductive Endocrinology; Research; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Research Technics; Resources; Safety; San Francisco; Site; Smoke; Technology; Tissues; Training Programs; Translational Research; Underrepresented Minority; Universities; Vaccines; Wildfire; Work; climate change; climate impact; clinical care; community partnership; coronavirus disease; ethnic diversity; experience; fetal; health disparity; health equity promotion; high risk; implementation science; improved; improved outcome; in utero; infant morbidity/mortality; innovation; marginalized community; medical specialties; metagenomic sequencing; microbial; multidisciplinary; new technology; novel; novel strategies; novel therapeutics; obstetric care; obstetrical complication; opioid epidemic; patient oriented; patient population; perinatal medicine; perinatal mental health; personalized approach; precision medicine; pregnancy health; pregnant; programs; racial diversity; racial population; recruit; reproductive outcome; success; transplantation medicine; treatment program

PROJECT SUMMARY Significant disparities in maternal and infant mortality and morbidity exist in the U.S, and the MFMU Network aims to reduce the rates of preterm birth, fetal growth abnormalities, newborn morbidity, and maternal complications of pregnancy. Novel strategies, including new therapies and technologies, innovative study designs and interventions, attention to implementation science, inclusion of adequately diverse study participants into clinical trials, and input from the stakeholders impacted by health disparities are needed to improve outcomes for pregnant and lactating people. Although California accounts for nearly one eighth of annual U.S. births, the MFMU Network lacks a West Coast site. The University of California, San Francisco (UCSF) has a racially and ethnically diverse patient population, including many individuals with differing gender identities. The inclusion of historically marginalized communities, including segments of the population that are highly represented in California, will ensure the MFMU Network study results are generalizable, and will promote health equity for all persons. UCSF is a pioneer in innovative research techniques, such as genomics and metagenomics, as well as clinical research methods, including community partnership and implementation science. In addition, UCSF has a robust research infrastructure that has supported numerous translational investigations including epigenetics and infection studies, metagenomic sequencing in pregnant patients with obstetric complications, studies of environmental contaminants such as wildfire smoke on reproductive outcomes, and placental biology, including the impact of COVID-19 and COVID vaccines. UCSF has an extensive network of affiliated practices and referring hospitals that provide care for diverse patient populations with a myriad of pregnancy- related complications and together with its affiliate, Zuckerberg San Francisco General Hospital, performs nearly 4000 deliveries per year in mostly high-risk patients. Therefore, to support the mission of the MFMU Network, we will 1) Enroll a large and uniquely diverse, west coast participant population; 2) Contribute multidisciplinary expertise of UCSF investigators to high priority areas of public health that impact pregnant people and/or their infants, such as the COVID pandemic, the opioid crisis, and the impacts of climate change; and 3) Leverage our affiliation with the MFMU Network to develop a diverse group of young academic investigators. UCSF will bring a host of novel and innovative opportunities, including clinical populations and unique technological and research approaches that will strengthen the work of the MFMU Network.

项目摘要 在美国，产妇和婴儿死亡率和发病率存在显著差异，MFMU网络 旨在降低早产率、胎儿生长异常、新生儿发病率和孕产妇死亡率。 妊娠并发症。新策略，包括新疗法和技术，创新研究 设计和干预措施，关注实施科学，纳入充分多样化的研究 参与者进入临床试验，需要受健康差异影响的利益相关者的投入， 改善孕妇和哺乳期人群的结局。虽然加州占了近八分之一的 由于MFMU网络每年在美国出生，因此缺乏西海岸的网站。加州大学旧金山分校弗朗西斯科 （UCSF）有一个种族和种族多样化的患者群体，包括许多不同性别的个体 身份纳入历史上被边缘化的社区，包括被边缘化的人口群体， 在加州有很高的代表性，将确保MFMU网络的研究结果是可推广的，并将 促进所有人的健康公平。 UCSF是创新研究技术的先驱，如基因组学和宏基因组学，以及 临床研究方法，包括社区伙伴关系和实施科学。此外，UCSF 拥有强大的研究基础设施，支持了众多的翻译研究，包括 表观遗传学和感染研究，对有产科并发症的孕妇进行宏基因组测序， 研究环境污染物，如野火烟雾对生殖结果和胎盘 生物学，包括COVID-19和COVID疫苗的影响。UCSF拥有广泛的附属网络， 实践和转诊医院，为各种各样的怀孕患者提供护理- 相关并发症，并与其附属公司，扎克伯格旧金山弗朗西斯科总医院，执行 每年有近4000例分娩，大多数是高危患者。 因此，为了支持MFMU网络的使命，我们将1）招收一个大型的，独特的多样化，西 海岸参与人口; 2）贡献UCSF研究人员的多学科专业知识，以高度优先 影响孕妇和/或其婴儿的公共卫生领域，如COVID大流行， 阿片类药物危机和气候变化的影响;以及3）利用我们与MFMU网络的联系， 培养一批多样化的年轻学术研究人员。UCSF将带来一系列新颖和创新的 机会，包括临床人群和独特的技术和研究方法， 加强MFMU网络的工作。