Baylor College of Medicine & Texas Children's Clinical Center for Research in the NICHD Maternal-Fetal Medicine Units (MFMU) Network

1986年，NICHD建立了MFMU网络，以满足对围产期精心设计的试验的需求 医药。MFMU网络的主要目标是改善产科护理、妊娠健康和结局 通过建立和维护学术合作网络，为怀孕和哺乳期的人及其婴儿 严格执行多中心临床方案的中心。我们的申请书名为“贝勒学院 医学(BCM)和德克萨斯儿童临床研究中心在NICHD母胎医学部(MFMU) 电视网将达到并超过这些既定目标。在对这一应用的预期中，我们在过去的十年里 在我们的母胎医学(MFM)学术团队中培养一种文化，鼓励临床研究 这是降低孕产妇和新生儿发病率和死亡率的一个重要部分。创新与最新科技 我们一路上开发的翻译和临床研究基础设施将使成功 在我们中心实施和执行MFMU研究，丰富网络科学。具体目标1. 作为一支敬业的母婴医学(MFM)医生团队，通力合作 医生科学家开发、实施和执行MFMU网络试验。来自我们38个ABOG的学术部门 认证/合格的MFM医生，我们已经组建了一支由临床科学家组成的核心团队，他们之前有重要的MFMU和 其他临床试验经验，证明了学术效率，以及广泛的临床和翻译 能力。KJersti Aagaard博士(PI)和Carey Eppes博士(替补PI)将继续他们长达十年的旅程 敬业的“MFM临床团队科学领袖”。与现有的专注的MFM研究人员携手合作，这 团队是在部门和机构承诺的坚定承诺下建立的(投入时间和资金 资源)，并致力于生成必要的证据，为所有孕妇提供最佳临床护理。 具体目标2.支持我们独特而强大的人口的招募、登记和长期跟踪 可用于临床试验的受孕者。我们在德克萨斯州的两个主要MFMU临床地点几乎相邻 休斯顿医疗中心，每年有超过11,000次分娩，有近2/3的“高风险”和 在我们的MFMU临床中心STIES接受了大部分的产前护理。我们将阐述我们将如何协同 通过招募和留住受影响较大的人群来丰富整个网络的范围和影响。 具体目标3.利用贝勒医学院/德克萨斯儿童医院的临床和转化研究能力 MFMU临床中心，以发展和扩大MFMU网络的科学内涵。深度和深度 广泛的临床专业知识、临床试验经验，尤其是专注于 怀孕和哺乳是这一应用的独特优势。我们将详细介绍我们部门经过验证的能力 成员和我们的合作者，并确定我们近乎无与伦比的特殊优势将如何共享和使用 支持创新和推进MFMU和NICHD的科学目标、愿景和使命。

In 1986, the NICHD established the MFMU Network to respond to the need for well-designed trials in perinatal medicine. The primary objective of the MFMU Network is to improve obstetrics care, pregnancy health, and outcomes for pregnant and lactating people and their infants by establishing and maintaining a cooperative network of academic centers that perform multi-center clinical protocols in a rigorous manner. Our application entitled ‘Baylor College of Medicine (BCM) and Texas Children’s Clinical Center for Research in the NICHD Maternal-Fetal Medicine Units (MFMU) Network’ will meet and exceed these stated goals. In anticipation of this application, we have spent the last decade cultivating a culture amongst our academic Maternal-Fetal Medicine (MFM) team which encourages clinical research as part and parcel to reducing maternal and neonatal morbidity and mortality. The innovation and state-of-the-science translational and clinical research infrastructure we have developed along the way will enable successful implementation and execution of MFMU studies at our Center, and enrich the science of the Network. Specific Aim 1. Work cooperatively and collaboratively as a team of dedicated academic Maternal-Fetal Medicine (MFM) physicians and physician scientists to develop, implement, and execute MFMU Network trials. From our academic division of 38 ABOG certified/eligible MFM physicians, we have assembled a core team of clinician scientists with prior significant MFMU and other clinical trials experience, demonstrated academic productivity, and a breadth of clinical and translational capabilities. Drs. Kjersti Aagaard (PI) and Carey Eppes (Alternate PI) will continue their decade-long journey as dedicated “MFM clinical team science leaders”. Working hand-in-hand with existing dedicated MFM research staff, this team is built with the firm promise of Departmental and Institutional Commitment (dedicated time & financial resources) and is dedicated to generating the evidence necessary to inform best clinical care for all pregnant people. Specific Aim 2. Enable the recruitment, enrollment, and long term follow up of our unique and robust population of gravidae available for clinical trials. Our two principal MFMU clinical sites are nearly adjacent to each other in the Texas Medical Center in Houston, and are the site of over 11,000 deliveries annually, with nearly 2/3 “high risk” and having received the majority of their prenatal care at our MFMU clinical center sties. We will address how we will synergistically enrich the overall Network scope and impact by recruiting & retaining populations who are disproportionately affected. Specific Aim 3. Leverage the clinical and translational research capabilities at Baylor College of Medicine/Texas Children’s MFMU Clinical Center in order to develop and expand the scientific richness of the MFMU Network. The depth and breadth of clinical expertise, clinical trials experience, and notably cutting-edge translational research that focus on pregnancy and lactation are unique strengths of this application. We will detail the proven capabilities of our Division members and our collaborators, and identify how our nearly unparalleled special strengths will be shared and available to bolster the innovation and advancement of the scientific goals, vision and mission of the MFMU and the NICHD.