Baylor College of Medicine & Texas Children's Clinical Center for Research in the NICHD Maternal-Fetal Medicine Units (MFMU) Network

贝勒医学院

• 批准号: 10682975
• 负责人: MICHAEL A BELFORT
• 金额: $ 33.34万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682975
• 关键词: Affect; Caring; Certification; Child; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Clinical Trials Unit; Collaborations; Dedications; Discipline of obstetrics; Elements; Eligibility Determination; Enrollment; Funding; Goals; Infant; Institution; Lactation; Leadership; Letters; Longterm Follow-up; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Medical center; Medicine; Mission; Multi-Institutional Clinical Trial; National Institute of Child Health and Human Development; Neonatal; Neonatal Intensive Care; Outcome; Participant; Patients; Performance; Perinatal; Persons; Physicians; Population; Pregnancy; Prenatal care; Productivity; Research; Research Infrastructure; Resources; Rewards; Risk; Science; Science Enrichment; Scientific Advances and Accomplishments; Scientist; Site; Texas; Time; Translational Research; Translations; United States; United States National Institutes of Health; Vision; Vulnerable Populations; Work; clinical care; clinical center; clinical research site; college; experience; follow-up; high risk; improved; innovation; maternal morbidity; member; mortality; neonatal morbidity; obstetric care; perinatal medicine; pregnancy health; pregnant; recruit; research study; success; translational impact; trial design

In 1986, the NICHD established the MFMU Network to respond to the need for well-designed trials in perinatal medicine. The primary objective of the MFMU Network is to improve obstetrics care, pregnancy health, and outcomes for pregnant and lactating people and their infants by establishing and maintaining a cooperative network of academic centers that perform multi-center clinical protocols in a rigorous manner. Our application entitled ‘Baylor College of Medicine (BCM) and Texas Children’s Clinical Center for Research in the NICHD Maternal-Fetal Medicine Units (MFMU) Network’ will meet and exceed these stated goals. In anticipation of this application, we have spent the last decade cultivating a culture amongst our academic Maternal-Fetal Medicine (MFM) team which encourages clinical research as part and parcel to reducing maternal and neonatal morbidity and mortality. The innovation and state-of-the-science translational and clinical research infrastructure we have developed along the way will enable successful implementation and execution of MFMU studies at our Center, and enrich the science of the Network. Specific Aim 1. Work cooperatively and collaboratively as a team of dedicated academic Maternal-Fetal Medicine (MFM) physicians and physician scientists to develop, implement, and execute MFMU Network trials. From our academic division of 38 ABOG certified/eligible MFM physicians, we have assembled a core team of clinician scientists with prior significant MFMU and other clinical trials experience, demonstrated academic productivity, and a breadth of clinical and translational capabilities. Drs. Kjersti Aagaard (PI) and Carey Eppes (Alternate PI) will continue their decade-long journey as dedicated “MFM clinical team science leaders”. Working hand-in-hand with existing dedicated MFM research staff, this team is built with the firm promise of Departmental and Institutional Commitment (dedicated time & financial resources) and is dedicated to generating the evidence necessary to inform best clinical care for all pregnant people. Specific Aim 2. Enable the recruitment, enrollment, and long term follow up of our unique and robust population of gravidae available for clinical trials. Our two principal MFMU clinical sites are nearly adjacent to each other in the Texas Medical Center in Houston, and are the site of over 11,000 deliveries annually, with nearly 2/3 “high risk” and having received the majority of their prenatal care at our MFMU clinical center sties. We will address how we will synergistically enrich the overall Network scope and impact by recruiting & retaining populations who are disproportionately affected. Specific Aim 3. Leverage the clinical and translational research capabilities at Baylor College of Medicine/Texas Children’s MFMU Clinical Center in order to develop and expand the scientific richness of the MFMU Network. The depth and breadth of clinical expertise, clinical trials experience, and notably cutting-edge translational research that focus on pregnancy and lactation are unique strengths of this application. We will detail the proven capabilities of our Division members and our collaborators, and identify how our nearly unparalleled special strengths will be shared and available to bolster the innovation and advancement of the scientific goals, vision and mission of the MFMU and the NICHD.

1986年，NICHD建立了MFMU网络，以满足对精心设计的围产期试验的需求