Feasibility of Linking the Occupational Exposome to Alzheimer's Disease Neuropathology

职业暴露组涵盖一生中发生的所有职业暴露 当然影响健康。阿尔茨海默病 (AD) 的生物学过程如何，例如 AD 神经病理学，受职业暴露的影响是有限的。证据表明有效 一个人的工作生活与大脑结构变化和健康状况不佳有关 差异。然而，捕获职业暴露在技术上具有挑战性，导致 健康差异和 AD 研究中很少有实际方法。但方法论上 进步是可能的。 生命历程公共数据追踪方法有望成为一种量化生命历程的新方法 职业暴露组，在此过程中创建可链接到 AD 的“新”历史数据库 生物样本库。此类方法通常保留用于谱系研究，但未得到充分利用 将社会决定因素与健康差异联系起来。这些方法涉及 系统地搜索公开的历史记录并提取信息 一个人的生活，包括美国人口普查记录、城市名录、军事记录、死亡记录，以及 报纸来源。职业暴露从未以这种方式与 脑组织和相关神经病理学——诊断 AD 的“金标准”。 建立一种将职业暴露与 AD 生物学结果联系起来的可行方法 可能会帮助新的寡妇了解这种不治之症的驱动因素；提供洞察力 剂量和时间，并揭示所涉及的关键中介和调节因素。然而 揭示这些机械基础的基础工作尚不完善。 本提案是了解工作条件和 生命历程中的环境会影响 AD 大脑健康。我们建议研究可行性 使用生命历程公共数据追踪方法、人行横道来捕获职业历史 在职业信息网络中建立高压力工作特征暴露 数据库 (O*NET)，并将这些暴露附加到我们现有的多 ADRC 脑库样本中 探索与 AD 神经病理学的关联。总体假设是公共数据 追踪方法可用于可靠地构建有效的职业历史，并与 职业暴露来研究工作在 AD 大脑健康差异中的作用。

The occupational exposome encompasses all occupational exposures occurring over the life course that affect health. How Alzheimer's disease (AD) biological processes, such as AD neuropathology, are impacted by the occupational exposome is limited. Evidence suggests work and one's working life is linked to structural brain changes and poorer health and health disparities. Yet capturing the occupational exposome has been technically challenging, leading to few practical approaches within health disparity and AD research. But methodological advancements are possible. Lifecourse public data tracing methods holds promise as a novel way to quantify the occupational exposome, creating “new” historic databases in the process that are linkable to AD biobanks. Such methods are typically reserved for genealogical research and are underutilized in connecting social determinants to study health disparities. These methods involve systematically searching publicly available historical records and extracting information across one's life including US Census records, city directories, military records, death records, and newspapers sources. Never before has the occupational exposome been linked in this way to brain tissue and related neuropathology—the `gold standard' for diagnosing AD. Establishing a feasible way to link the occupational exposome to AD biological outcomes may unlock new widows in understanding the drivers of this incurable disease; providing insight into dosage and timing, and uncovering the key mediating and moderating factors involved. Yet the groundwork to uncover these mechanistic underpinnings is underdeveloped. The present proposal is an initial step towards understanding how working conditions and contexts over the life course impact AD brain health. We propose to study the feasibility of capturing occupational histories using lifecourse public data tracing methods, crosswalk to established high stress job characteristic exposures in the Occupational Information Network database (O*NET), and append these exposures to our existing multi-ADRC brain bank sample to explore associations with AD neuropathology. The overarching hypothesis is that public data tracing methods can be used to reliably construct valid occupational histories, and be linked to occupational exposures to study the role of work in AD brain health disparities.