2023 Barrier Function of Mammalian Skin Gordon Research Conferences and Gordon Research Seminar

项目总结 成立于1989年的戈登哺乳动物皮肤屏障功能研究会议，已有30多年的历史 仍然是成功地融合了多个学科和 主题侧重于了解哺乳动物皮肤屏障的机制及其在健康和健康中的维护 疾病。会议的成功(从议题和发言者的多样性、申请者群体的规模、 非常正面的评价)源于话题的多样性、性别/种族/民族的包容性和对 在科学家职业生涯的早期阶段提拔他们。2023年大会的首要主题是“智能” 和个性化的皮肤屏障：细胞和生物学、生物工程和物理化学的翻译 汇集年轻调查人员和知名领导人的独特组合，介绍 细胞生物学、病理学、微生物学、环境科学、生物工程、生物物理学、物理化学、 和药物递送，专注于利用精准医学方法来个性化临床护理并最大限度地减少 接触化学物质。本次会议的总体目标和长期目标是提出新颖的 发现并讨论这些不同专业领域的最新发展 非正式讨论，并为协同团队方法的新协作机会提供平台 促进未来的发现和新的治疗方法，将推动这一多学科领域的发展。 此外，目标也是鼓励关于新领域和未来重大问题的讨论。 挑战以及应对挑战的方法。为促进讨论并使发言者和主题多样化， 所有演讲者将被新邀请(没有在2019 GRC上发言)，30%的计划将致力于 年轻的研究人员从提交的摘要中挑选出来。我们将举办一次动力小时活动，以方便重要的 讨论“科学歧视”的各个方面，包括促进种族/民族多样性 通过将致力于表皮屏障的不同研究人员社区的科学家聚集在一起。这个 2023年会议的主要主题将包括老龄化和环境对屏障的影响， 动态平衡和疾病中的微生物区系和宿主反应，预测渗透和化学风险的方法 暴露、药物传递的优化、大数据和精准医学(从基因组学、临床 从诊断到成像)，以及优化疗法。虽然这些主题定义了议程，但该计划将 包括从提交的摘要中挑选出来的简短口头演讲。每节课将包含1-2篇这样的短文 演讲，最大限度地提供机会，包括最新的研究，并为年轻的受训人员提供一个平台和知名度。 在这次会议上形成的新进展、知识共享和新的多学科合作， 再加上与会者之间的互动，将极大地促进共同的理解目标 表皮屏障功能，以改善局部、皮肤和全身的健康。

PROJECT SUMMARY Established in 1989 The Gordon Research Conference on Barrier Function of Mammalian Skin, for over 30 years remains to be the premiere international scientific meeting that successfully incorporates multiple disciplines and topics focusing on understanding the mechanisms of mammalian skin barrier and its maintenance in health and disease. The success of the meeting (evidenced by diversity of topics and speakers, size of the applicant pool, extremely positive reviews) derives from variety in topics, gender/race/ethnicity inclusion and commitment to promote scientists in the early stage of their careers. The overarching theme of the 2023 conference is "Intelligent and personalized skin barrier: translation of cell and biology, bioengineering and physical chemistry” which will bring together a unique blend of young investigators and prominent leaders to present latest developments in cell biology, pathology, microbiology, environmental sciences, bioengineering, biophysics, physical chemistry, and drug delivery focusing on utilizing precision medicine approaches to personalize clinical care and minimize chemical exposure. The overarching objective and long-term goals of this conference is to present novel discoveries and discuss the latest developments in these different fields of expertise through both formal and informal discussions and to provide a platform for new collaborative opportunities of synergistic team approaches to facilitate future discoveries and novel therapeutic approaches that will advance this multi-disciplinary field. Moreover, the goal is also to stimulate discussions regarding new frontiers and future big questions and challenges as well as approaches to tackle them. To promote discussions and diversify of speakers and topics, all speakers will be newly invited (did not speak at the 2019 GRC) and 30% of the program will be dedicated to young investigators selected from submitted abstracts. We will hold a power hour to facilitate important discussions regarding various aspects of “discrimination in science” including promotion of racial/ethnic diversity by bringing together scientists from the diverse community of researchers working on the epidermal barrier. The major themes of the 2023 conference will include aging and environmental effects on barrier, cross talk of microbiota and host-response in homeostasis and disease, approaches to predict permeation and chemical risk exposure, optimization of drug delivery, big data and precision medicine (ranging from genomics, clinical diagnostics to imaging), and optimizing therapeutics. While these themes define the agenda, the program will incorporate short oral talks selected from the submitted abstracts. Each session will incorporate 1-2 such short talks, maximizing the opportunity to include latest research and provide a platform and visibility to young trainees. The new advances, knowledge sharing, and new multi-disciplinary collaborations forged at this conference, coupled with the interactions between attendees, will greatly advance the shared goal of understanding epidermal barrier function to improve health both locally, in the skin, and systemically.