2023 Barrier Function of Mammalian Skin Gordon Research Conferences and Gordon Research Seminar

项目摘要 成立于1989年的Gordon Research Conference on Barrier Function of Mammalian Skin，已有30多年的历史。 仍然是成功融合多学科的首要国际科学会议， 主题侧重于了解哺乳动物皮肤屏障的机制及其在健康和 疾病会议的成功（由主题和发言者的多样性，申请人的规模， 非常积极的评价）源于主题的多样性、性别/种族/民族的包容性和对 促进科学家在其职业生涯的早期阶段。2023年会议的首要主题是“智能 和个性化的皮肤屏障：翻译细胞和生物学，生物工程和物理化学”，这将 汇集了年轻的研究人员和杰出的领导人的独特组合，介绍最新的发展， 细胞生物学，病理学，微生物学，环境科学，生物工程，生物物理学，物理化学， 和药物输送，重点是利用精准医学方法来个性化临床护理， 化学暴露本次会议的总体目标和长期目标是提出新颖的 发现和讨论在这些不同的专业领域的最新发展，通过正式和 进行非正式讨论，并为采用协同团队方法的新合作机会提供平台 以促进未来的发现和新的治疗方法，将推动这一多学科领域。 此外，其目标还在于激发关于新领域和未来重大问题的讨论， 挑战以及应对这些挑战的方法。为了促进讨论并使发言者和主题多样化， 所有演讲者都将是新邀请的（没有在2019年GRC上发言），30%的节目将用于 从提交的摘要中选出的年轻研究人员。我们将举行一个电力小时，以促进重要的 讨论“科学歧视”的各个方面，包括促进种族/族裔多样性 通过将来自不同研究社区的科学家聚集在一起，研究表皮屏障。的 2023年会议的主要主题将包括老化和环境对屏障的影响， 微生物群和宿主在体内平衡和疾病中的反应，预测渗透和化学风险的方法 暴露、药物递送优化、大数据和精准医学（从基因组学、临床 诊断到成像），以及优化治疗。虽然这些主题定义了议程，但该计划将 纳入从提交的摘要中选出的简短口头发言。每节课将包括1-2个这样的短 讲座，最大限度地利用机会，包括最新的研究，并提供一个平台和能见度，以青年学员。 新的进展，知识共享，以及在这次会议上形成的新的多学科合作， 再加上与会者之间的互动，将大大促进共同的目标， 表皮屏障的功能，以改善健康的局部，在皮肤上，和全身。

PROJECT SUMMARY Established in 1989 The Gordon Research Conference on Barrier Function of Mammalian Skin, for over 30 years remains to be the premiere international scientific meeting that successfully incorporates multiple disciplines and topics focusing on understanding the mechanisms of mammalian skin barrier and its maintenance in health and disease. The success of the meeting (evidenced by diversity of topics and speakers, size of the applicant pool, extremely positive reviews) derives from variety in topics, gender/race/ethnicity inclusion and commitment to promote scientists in the early stage of their careers. The overarching theme of the 2023 conference is "Intelligent and personalized skin barrier: translation of cell and biology, bioengineering and physical chemistry” which will bring together a unique blend of young investigators and prominent leaders to present latest developments in cell biology, pathology, microbiology, environmental sciences, bioengineering, biophysics, physical chemistry, and drug delivery focusing on utilizing precision medicine approaches to personalize clinical care and minimize chemical exposure. The overarching objective and long-term goals of this conference is to present novel discoveries and discuss the latest developments in these different fields of expertise through both formal and informal discussions and to provide a platform for new collaborative opportunities of synergistic team approaches to facilitate future discoveries and novel therapeutic approaches that will advance this multi-disciplinary field. Moreover, the goal is also to stimulate discussions regarding new frontiers and future big questions and challenges as well as approaches to tackle them. To promote discussions and diversify of speakers and topics, all speakers will be newly invited (did not speak at the 2019 GRC) and 30% of the program will be dedicated to young investigators selected from submitted abstracts. We will hold a power hour to facilitate important discussions regarding various aspects of “discrimination in science” including promotion of racial/ethnic diversity by bringing together scientists from the diverse community of researchers working on the epidermal barrier. The major themes of the 2023 conference will include aging and environmental effects on barrier, cross talk of microbiota and host-response in homeostasis and disease, approaches to predict permeation and chemical risk exposure, optimization of drug delivery, big data and precision medicine (ranging from genomics, clinical diagnostics to imaging), and optimizing therapeutics. While these themes define the agenda, the program will incorporate short oral talks selected from the submitted abstracts. Each session will incorporate 1-2 such short talks, maximizing the opportunity to include latest research and provide a platform and visibility to young trainees. The new advances, knowledge sharing, and new multi-disciplinary collaborations forged at this conference, coupled with the interactions between attendees, will greatly advance the shared goal of understanding epidermal barrier function to improve health both locally, in the skin, and systemically.