2023 Functional Genomics of Human Brain Development and Disease Gordon Research Conference

2023年人脑发育与疾病功能基因组学戈登研究会议

• 批准号: 10683598
• 负责人: ELISABETH B. BINDER
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-05 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10683598
• 关键词: Academia; Acceleration; Alzheimer' s Disease; Biological Assay; Biotechnology; Brain; Brain Diseases; Career Choice; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Complex; DNA Sequence; Development; Diagnostic; Disease; Disease Progression; Education; Engineering; Environment; Epigenetic Process; Female; Fostering; Future; Gene Expression Regulation; Generations; Genes; Genetic study; Genome engineering; Genomics; Goals; Grant; Health; Hour; Human; Industry; Learning; Maps; Modeling; Molecular; Nerve Degeneration; Neuroglia; Neurologic; Neurons; Neurosciences Research; Nobel Prize; Organoids; Participant; Patients; Postdoctoral Fellow; Public Health; Research; Research Personnel; Schizophrenia; Scientist; Stem Cell Research; Technology; Therapeutic Intervention; Time; Translating; Underrepresented Minority; United States National Academy of Sciences; United States National Institutes of Health; Universities; Variant; Wisconsin; Woman; autism spectrum disorder; career; clinically actionable; disorder risk; diversity and inclusion; empowerment; environmental enrichment for laboratory animals; functional genomics; genetic architecture; genome editing; genome-wide; graduate student; human disease; human model; human stem cells; improved; individualized medicine; informal atmosphere; insight; male; meetings; member; multidisciplinary; neurogenomics; new technology; new therapeutic target; novel; novel strategies; posters; prognostic; programs; stem cell model; stem cells; symposium; tool

Project Summary/Abstract This 2023 Functional Genomics of Human Brain Development and Disease GRC conference seeks to bring together a multidisciplinary and diverse group of geneticists, neuroscientists, and stem cell biologists endeavoring to improve diagnostics, prognostics, and treatment of brain disease. The conference will explore (1) genomics of brain diseases, (2) applications of high-throughput genomic assays and screens, (3) technological advances in reprogramming, differentiation, and genome-engineering; (4) new insights into human brain development and disorders obtained through technologies; and (5) progress towards novel therapeutic targets and interventions. Whereas large-scale genomic studies are uncovering the complex genetic architecture of gene regulation and disease risk, the causal cellular mechanisms of disease risk and progression remain unclear. While the generation of patient-specific neurons, glia, and organoids facilitate the study of human brain development, CRISPR-based engineering approaches facilitate single or genome-wide perturbations in DNA sequence or epigenetic activity; their integration makes it possible to investigate the molecular mechanisms of disease-associated variations. Together, these approaches translate the myriad advances from large-scale genetic studies into clinically actionable information. This 2023 Functional Genomics of Human Brain Development and Disease GRC conference will contribute to improving our understanding the cellular and molecular mechanisms involved in regulating human brain development in health and disease. The attendees are also expected to form new connections with the leaders in industry and academia for setting new collaborations and starting new careers.

项目摘要/摘要 2023年人类大脑发育和疾病的功能基因组学GRC会议寻求带来 一个由遗传学家、神经学家和干细胞生物学家组成的多学科和多样化的团体聚集在一起 致力于改善脑部疾病的诊断、预后和治疗。会议将探讨 (1)脑部疾病的基因组学，(2)高通量基因组分析和筛选的应用，(3) 重新编程、分化和基因组工程方面的技术进步；(4)对 通过技术获得的人脑发育和障碍；以及(5)向创新的进展 治疗目标和干预措施。而大规模的基因组研究正在揭示这种复合体 基因调控和疾病风险的遗传结构，疾病风险的原因细胞机制和 进展尚不清楚。而患者特有的神经元、神经胶质细胞和器官类物质的产生促进了 人脑发育研究，基于CRISPR的工程方法促进单个或全基因组 DNA序列或表观遗传活性的扰动；它们的整合使研究 疾病相关变异的分子机制。总而言之，这些方法转化了无数 从大规模基因研究到临床可操作信息的进展。 2023年人类大脑发育和疾病功能基因组学GRC会议将有助于 提高我们对调节人脑的细胞和分子机制的理解 健康和疾病方面的发展。预计与会者还将与领导人建立新的联系 在工业界和学术界建立新的合作和开始新的职业生涯。