NICHD Neonatal Research Network

NICHD 新生儿研究网络

• 批准号: 10682748
• 负责人: Jill Lamanna Maron
• 金额: $ 1.75万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682748
• 关键词: 7 year old; Affect; Area; Behavioral; Biological Markers; Caring; Childhood; Clinical; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Critical Illness; Development; Diagnostic tests; Evidence based treatment; Family; Foundations; Genomics; Goals; Healthcare; Home; Hospital Costs; Hospitals; Image; Infant; Infusion procedures; Intensive Care; Leadership; Link; Magnetic Resonance Imaging; Massachusetts; Maternal-Fetal Medicine Units Network; Maternal-fetal medicine; Measures; Mission; Morbidity - disease rate; Mothers; Multicenter Neonatal Research Network; Multicenter Studies; Multicenter Trials; National Institute of Child Health and Human Development; Neonatal; Neonatal Intensive Care Units; Newborn Infant; Outcome; Outcome Study; Perinatal; Physicians; Pregnancy; Premature Infant; Productivity; Protocols documentation; Reproducibility; Research; Research Infrastructure; Research Personnel; Rhode Island; Scientist; Sepsis; Site; Solid; Term Birth; United States; Woman; Work; clinical practice; critically ill newborn; data sharing; design; early childhood; evidence base; experience; follow-up; high risk; hospitalization rates; improved; improved outcome; innovation; neurobehavior; novel; novel marker; outreach; patient population; perinatal medicine; premature; preterm newborn; prognostic assays; programs

PROJECT SUMMARY/ABSTRACT Advances in the care of preterm and term newborns continues to demonstrate progress. However, adverse childhood outcomes following morbidities of prematurity (BPD, IVH, NEC and others) and conditions affecting late preterm and term infants (HIE, PPHN, sepsis) remain excessively high. The overarching goal of the Brown Neonatal Research Network (NRN) Center is to identify critical gaps that contribute to undesirable newborn outcomes and expand the evidence base to guide treatment and management with exceptionally high-quality clinical research. Our specific goals are to bring fresh innovation to the NRN in domains of novel biomarkers, genomics, neurobehavior and imaging and apply these to the design of timely clinical trials. New trials need to be rigorous and reproducible since the ultimate measure of impact is whether the results drive change in clinical practice. To accomplish our goals, the Brown NRN Center has been invigorated with important leadership transitions among our physician scientists and research coordinator. We anticipate that our new investigators will provide an infusion of novel ideas and areas of expertise which will build upon our solid foundation. The latter has been created by our current investigators who will remain active in the NRN and help maintain our longstanding clinical and research practices. That includes meaningful contributions to the NRN since 1991 in which Brown investigators have led multi-center trials, made substantial contributions to trial development, and conducted trials well. Our clinical research productivity is also reflected in our ability to perform high quality clinical trials outside the NRN framework and reflects a deep commitment to our academic mission. The Brown NRN Center is based at a single center, Women & Infants Hospital of Rhode Island (WIH) which functions as the hub of a well-organized perinatal region encompassing all of Rhode Island and southeastern Massachusetts. WIH performs 80% of the deliveries in Rhode Island and through its Maternal Fetal Medicine outreach, and maternal/neonatal transports, impacts close to 15,000 deliveries a year. The Brown NRN Center has close links with our Maternal Fetal Medicine Unit Network (MFMU) colleagues and have demonstrated the ability to perform secondary studies of a MFMU clinical trial across the two networks. Our state-of-the-art Neonatal Intensive Care Unit has fully embraced a family-oriented approach to newborn intensive care where research and clinical management are linked reflecting our strong culture of research. Critical to the mission of the NRN and any regional center is a well-developed and effective follow-up program since primary study outcomes are often assessed between 2-7 years of age. The Brown NRN Center uses innovative programs such as Transition Home Plus to maintain relationships with families after discharge to home while reducing hospitalization rates and costs. The Brown NRN Center has a comprehensive array of clinical and research abilities to examine the mother-infant dyad and provide critical collaboration for the conduct of rigorous, cutting edge, multi-center trials that are the goals of the NRN.

项目概要/摘要 早产儿和足月新生儿的护理继续取得进展。然而，不利 早产儿发病（BPD、IVH、NEC 等）和影响疾病的情况后的儿童结局 晚期早产儿和足月儿（HIE、PPHN、脓毒症）的比例仍然过高。布朗的总体目标 新生儿研究网络 (NRN) 中心旨在找出导致不良新生儿的关键差距 结果并扩大证据基础以指导高质量的治疗和管理 临床研究。我们的具体目标是在新型生物标志物领域为 NRN 带来新的创新， 基因组学、神经行为和成像，并将其应用于及时临床试验的设计。新的试验需要 是严格的和可重复的，因为影响的最终衡量标准是结果是否推动变革 临床实践。为了实现我们的目标，布朗 NRN 中心注入了重要的活力 我们的医师科学家和研究协调员之间的领导层过渡。我们预计我们的新 调查人员将提供新颖的想法和专业领域的注入，这将建立在我们坚实的基础上 基础。后者是由我们当前的研究人员创建的，他们将继续活跃在 NRN 中并帮助 保持我们长期的临床和研究实践。这包括对 NRN 的有意义的贡献 自1991年以来，布朗大学的研究人员领导了多中心试验，为试验做出了重大贡献 开发并进行了良好的试验。我们的临床研究生产力还体现在我们的能力 在 NRN 框架之外进行高质量的临床试验，体现了对我们学术的坚定承诺 使命。布朗 NRN 中心位于罗德岛州妇婴医院 (WIH) 的单一中心 它是一个组织良好的围产期区域的中心，涵盖整个罗德岛州和 马萨诸塞州东南部。 WIH 负责罗德岛州 80% 的分娩，并通过其母公司 胎儿医学推广和孕产妇/新生儿运输每年影响近 15,000 例分娩。这 布朗 NRN 中心与我们的母胎医学单位网络 (MFMU) 同事有着密切的联系， 已证明能够跨两个网络对 MFMU 临床试验进行二次研究。 我们最先进的新生儿重症监护室完全采用以家庭为导向的新生儿护理方法 研究和临床管理相结合的重症监护反映了我们强大的研究文化。 对于 NRN 和任何区域中心的使命至关重要的是完善且有效的后续计划 因为主要研究结果通常在 2-7 岁之间进行评估。布朗 NRN 中心使用 诸如 Transition Home Plus 等创新计划可在出院后维持与家人的关系 回家，同时降低住院率和费用。布朗 NRN 中心拥有一系列全面的 检查母婴二元并为母婴提供关键合作的临床和研究能力 进行严格、前沿、多中心的试验是 NRN 的目标。