NICHD Neonatal Research Network - Stanford University

NICHD 新生儿研究网络 - 斯坦福大学

• 批准号: 10682147
• 负责人: Valerie Chock
• 金额: $ 33.97万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682147
• 关键词: Academic Medical Centers; Address; Admission activity; Adoption; Advisory Committees; Area; Asian; Asian population; Beds; Birth; Blood Transfusion; COVID-19 pandemic; Caring; Cerebrum; Certification; Clinical Investigator; Clinical Research; Collaborations; Communities; Data Coordinating Center; Development; Disparity; Education; Electroencephalography; Ensure; Faculty; Family; Funding; Future; Goals; Grant; Growth; Healthcare; Helping to End Addiction Long-term; Hispanic; Hispanic Populations; Hospitals; Industry; Infant; Infant Care; Information Dissemination; Institution; Intervention Trial; Investigation; Journals; Lactation; Lead; Leadership; Low Birth Weight Infant; Magnetic Resonance Imaging; Manuscripts; Medical center; Medicine; Mission; Morbidity - disease rate; Mothers; Multi-Institutional Clinical Trial; Multicenter Neonatal Research Network; Multicenter Trials; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; Near-Infrared Spectroscopy; Neonatal; Neonatology; Neurodevelopmental Impairment; Newborn Infant; Observational Study; Outcome; Oxygen saturation measurement; Participant; Patient Care; Patients; Peer Review; Perinatology; Phototherapy; Policies; Population; Population Heterogeneity; Positioning Attribute; Pregnant Women; Premature Infant; Procedures; Process; Productivity; Protocols documentation; Public Health; Publications; Publishing; Quality of Care; Reader; Recording of previous events; Reproducibility; Research; Research Design; Research Personnel; Resources; Rest; Secondary to; Shapes; Site; Talents; Time; Training; Transfusion; Underserved Population; United States National Institutes of Health; Universities; Visit; Woman; base; clinical center; clinical research site; community engagement; demographics; experience; follow-up; health goals; high risk; improved; innovation; member; natural hypothermia; neonatal care; neonatal encephalopathy; neonate; new technology; novel strategies; opioid exposure; outcome prediction; pandemic disease; patient population; perinatal medicine; premature; protocol development; randomized trial; safety net; symposium; tool

PROJECT SUMMARY The Division of Neonatal and Developmental Medicine at Stanford University submits a competing renewal application to participate in the NICHD Neonatal Research Network (NRN). The Division and its faculty members have a long history of innovative research accomplishments in neonatal medicine. This expertise dovetails with the NRN goal of conducting definitive and rigorous multicenter trials and observational studies in newborns to improve survival without neurodevelopmental impairment. As a participant in the NRN since 1991, this center has proven to be highly productive, contributing to leadership, study design, protocol development, execution, analysis, and results dissemination. Led by PI, Krisa Van Meurs, Alternate PI, Valerie Chock, and Follow-up PI, Susan Hintz, the site neonatologists and subspecialty collaborators have wide-ranging expertise and significant clinical research experience with 613 manuscripts published in neonates since 2016. Within the NRN, Stanford investigators have 55 subcommittee assignments and appear as co-authors 117 times on NRN manuscripts. Dr. Van Meurs is Chair of the Publications Committee and coordinated 131 manuscript reviews, spearheaded a review of NRN policies leading to a reduction in time to publication, and was Editor for the Seminars in Perinatology volume describing NRN contributions over the last grant cycle. As Lead Follow-up PI and Chair of Follow-up Protocol Development, Dr. Hintz has been responsible for advancing protocols and proposals, and assuring the quality of NRN follow up visits, and enhancing rigor of training and certification procedures. During the COVID pandemic she led re-envisioning of certification processes, launched new tools, and developed individualized improvement plans for challenged sites. Cody Arnold is Co-PI for the ongoing Cycled Phototherapy trial. Valerie Chock led a NHLBI-funded secondary to the Transfusion in Prematures trial on near-infrared spectroscopy (NIRS), Dr. Van Meurs led a secondary to the Optimizing Cooling trial on amplitude-integrated EEG, and Courtney Wusthoff led a secondary study to the Preemie Hypothermia trial on EEG. Stanford neuroradiologists have been MRI central readers for all the NRN cooling trials. The Stanford site with its 2 satellite sites, El Camino Hospital and Santa Clara Valley Medical Center, provide an annual delivery base of >12,000 births with 59% born to high risk mothers, 140 NICU beds, and >1900 NICU admissions with 83% inborn. Two sites anticipate growth in deliveries over the next 3 years. Our aggregate population is diverse in comparison to the rest of the US with 25% Asian and 52% Hispanic. Over the last 6 grant cycles Stanford has demonstrated wide-ranging expertise, exceptional leadership, and strong collaborative abilities that have served the NRN well. One of the greatest strengths Stanford has to offer is our extensive and talented pool of young clinical investigators that will become the clinical research leaders of the future. In summary, the Stanford site has the neonatal and subspecialty faculty, physical space, research resources, professional staff, institutional support, and patient population necessary to continue as one of the finest centers participating in the NRN.

项目总结 斯坦福大学新生儿和发育医学部提交了一份竞争性的续签申请 申请参加NICHD新生儿研究网络(NRN)。该司及其教职员工 会员在新生儿医学方面的创新研究成就源远流长。这一专业知识 与NRN在以下方面进行最终和严格的多中心试验和观察研究的目标相吻合 在没有神经发育障碍的情况下提高新生儿的存活率。自1991年以来，作为NRN的参与者， 该中心已被证明是高效的，有助于领导力、研究设计、方案开发、 执行、分析和结果发布。由Pi、Krisa Van Meur、Alternate Pi、Valerie Chock和 跟进Pi，Susan Hintz，该网站的新生儿专家和专科合作者拥有广泛的专业知识 自2016年以来发表在新生儿身上的613篇手稿，具有重要的临床研究经验。在 NRN，斯坦福大学的调查人员有55个小组委员会的任务，并以合著者的身份出现在NRN上117次 手稿。Van Meur博士是出版委员会主席，负责协调131份手稿评审工作， 带头审查NRN政策，缩短出版时间，并担任 围产期专题讨论会卷，描述了在上一个赠款周期中NRN的贡献。作为领先的跟进PI 作为后续协议开发的主席，欣茨博士一直负责推进协议和 建议，并确保NRN后续访问的质量，并加强培训和认证的严格性 程序。在COVID疫情期间，她领导了认证流程的重新设想，推出了新的工具， 并为有困难的地点制定了个性化的改进计划。科迪·阿诺德是正在进行的 循环光疗试验。Valerie Chock领导了NHLBI资助的早产儿输血试验的次要项目 在近红外光谱(NIRS)方面，Van Meur博士领导了优化冷却试验的次要步骤 幅度积分EEG，和Courtney Wusthoff领导了Preemie低温试验的二次研究 脑电波。斯坦福大学的神经放射学家一直是所有NRN冷却试验的MRI中心读者。斯坦福大学 网站及其两个卫星网站，埃尔卡米诺医院和圣克拉拉谷医疗中心，提供年度 12000名新生儿的分娩基地，其中59%是高危母亲所生，140张NICU床位和1900张NICU 83%的招生对象是先天的。两家网站预计未来3年的交货量将会增长。我们的总和 与美国其他地区相比，美国人口是多样化的，25%是亚裔，52%是西班牙裔。在过去6年中 格兰特循环斯坦福大学展示了广泛的专业知识、非凡的领导力和强大的 合作能力很好地服务于NRN。斯坦福大学提供的最大优势之一是我们的 广泛而有才华的年轻临床研究人员队伍，他们将成为 未来。总而言之，斯坦福大学的网站上有新生儿和子专业的教员、物理空间、研究 资源、专业人员、机构支持和患者人数，以继续成为 参加NRN的最好的中锋。