Adenosine Receptor Biased Agonism to Treat Ischaemic Heart Disease

腺苷A1受体（A1R）激活对心脏细胞具有强大的保护作用，但由于心率减慢和血压降低等副作用，临床应用仍不理想。重要的是，一类新的化合物，A1R偏倚激动剂，可以在没有副作用的情况下介导有效的心脏保护。该建议将建立相关的分子机制和开发A1R偏向激动剂作为治疗心脏病的新方法的范围。

Adenosine A1 receptor (A1R) activation confers powerful protection to heart cells, however clinical application remains suboptimal due to adverse effects such as a slowing in heart rate and decrease in blood pressure. Importantly a new class of compounds, A1R biased agonists, can mediate potent cardioprotection in the absence of adverse effects. This proposal will establish the molecular mechanisms involved and the scope to develop A1R biased agonists as a novel approach to treat heart disease.