Mechanisms underlying the contribution of uremic toxins to cardiorenal syndrome

尿毒症毒素导致心肾综合征的机制

• 批准号: nhmrc : 1087355
• 负责人: A/Pr Bing Wang
• 金额: $ 27.57万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-underlying-contribution-cardiorenal-syndrome/519174
• 关键词: Mechanisms; underlying; contribution; uremic; toxins

Cardiorenal syndrome (CRS) is an umbrella term that defines disorders of the heart and kidneys whereby “acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other”. We have demonstrated a significant association between heart and kidney fibrosis (scarring) and levels of a uremic toxin called indoxyl sulphate (IS), in relevant animal models and that blockade of production of this toxin reduces cardiac fibrosis. This project aims to explore this association.

肾综合征（CRS）是一个总括性术语，定义了心脏和肾脏疾病，其中“一个器官的急性或慢性功能障碍可能引起另一个器官的急性或慢性功能障碍”。我们已经在相关动物模型中证明了心脏和肾脏纤维化（瘢痕形成）与称为硫酸吲哚酚（IS）的尿毒症毒素水平之间的显著相关性，并且阻断这种毒素的产生可减少心脏纤维化。本项目旨在探索这种联系。