Mechanisms underlying the contribution of uremic toxins to cardiorenal syndrome

心肾综合征（CRS）是一个总称，定义了心脏和肾脏的疾病，其中“一个器官的急性或慢性功能障碍可能导致另一个器官的急性或慢性功能障碍”。在相关的动物模型中，我们已经证明了心脏和肾脏纤维化（瘢痕）与一种称为硫酸吲哚酚（IS）的尿毒症毒素水平之间存在显著关联，并且阻断这种毒素的产生可以减少心脏纤维化。本项目旨在探索这种联系。

Cardiorenal syndrome (CRS) is an umbrella term that defines disorders of the heart and kidneys whereby “acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other”. We have demonstrated a significant association between heart and kidney fibrosis (scarring) and levels of a uremic toxin called indoxyl sulphate (IS), in relevant animal models and that blockade of production of this toxin reduces cardiac fibrosis. This project aims to explore this association.