Investigating Pathways to Optimal Reproductive Outcomes Among Women with Rheumatic Diseases

研究患有风湿病的女性获得最佳生殖结果的途径

基本信息

项目摘要

ABSTRACT Pregnancy is a major cause of morbidity and mortality among women with rheumatic diseases and their children; thus, one of the most important decisions that a woman with a rheumatic disease may make is if and/or when she wishes to conceive. However, my foundational work has found that many of these women are unable to make informed decisions around pregnancy because their information needs are unmet. To meet this immediate and urgent patient need, I will develop a novel, patient-facing decision aid called MyVoice to help women to make informed pregnancy decisions and augment family planning care receipt in the rheumatology clinical setting (Aim 1). I will pilot MyVoice in rheumatology clinics to assess its feasibility, acceptability, and implementation potential (Aim 2). This work will serve as the foundation for a future hybrid implementation-effectiveness trial to evaluate if MyVoice increases women’s disease-specific reproductive knowledge and family planning care receipt, and ultimately improves their downstream reproductive outcomes. One of the major predictors of adverse pregnancy and perinatal outcomes among women with rheumatic diseases is active disease at the time of conception and during pregnancy. My prior work suggests that some women may experience active disease during pregnancy because they decide not to adhere to pregnancy-compatible anti- rheumatic drugs; they fear that their medications might adversely affect fetal development. In Aim 3, I will develop a longitudinal, exploratory cohort of young women with rheumatic diseases to evaluate how medication adherence is influenced by key time-varying and time-invariant upstream risk factors (i.e., pregnancy intentions, reproductive knowledge, symptom severity, family planning care receipt). In a subsequent R01 study, I will assess how these upstream factors lead to healthy or adverse reproductive outcomes-- thus, positioning me to identify novel targets for interventions that may enhance reproductive outcomes. I will maintain and expand this cohort over my career to serve as a source of additional hypotheses and scientific inquiry. Eighty percent of patients with rheumatic diseases are women, many of whom are reproductive-age when they are diagnosed; thus, my Aims are highly clinically relevant to rheumatology patients and practitioners. This K23 project will generate new knowledge that may be used to enhance the reproductive outcomes of a vulnerable group of women and their children. These Aims will also help me to meet my career objectives through development of a skill set that includes patient-centered intervention development, conduct of clinical trials, practical implementation, cohort creation, and advanced growth curve modeling to evaluate time-varying risk factors in my proposed cohort. My project provides preliminary data for two distinct but complementary paths to R01 funding. My outstanding mentorship team will support the successful completion of my Aims and career development milestones, to facilitate my transition to an independent outcomes researcher in rheumatology.
摘要

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Tough Choices: Exploring Medication Decision-Making During Pregnancy and Lactation Among Women With Inflammatory Arthritis.
  • DOI:
    10.1002/acr2.11240
  • 发表时间:
    2021-07
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Birru Talabi M;Eudy AM;Jayasundara M;Haroun T;Nowell WB;Curtis JR;Crow-Hercher R;White W;Ginsberg S;Clowse MEB
  • 通讯作者:
    Clowse MEB
How to Provide Sexual and Reproductive Health Care to Patients: Focus Groups With Rheumatologists and Rheumatology Advanced Practice Providers.
如何为患者提供性和生殖保健:风湿病学家和风湿病高级实践提供者的焦点小组。
  • DOI:
    10.3899/jrheum.220217
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Mitchell,Daiva;Lesoon,Leslie;Edens,Cuoghi;Kazmerski,TraciM;Stransky,OliviaM;Cameron,FlorA;Clowse,MeganEB;Borrero,Sonya;Hamm,Megan;Talabi,MehretBirru
  • 通讯作者:
    Talabi,MehretBirru
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Mehret Birru Talabi其他文献

Development of ReproKnow, a reproductive knowledge assessment for women with rheumatic diseases
开发 ReproKnow,针对患有风湿病的女性进行生殖知识评估
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Mehret Birru Talabi;M. Clowse;S. Blalock;G. Switzer;Lanskikh Yu;Alaina Chodoff;S. Borrero
  • 通讯作者:
    S. Borrero
Medication decision making under uncertainty: Considering chronic disease and pregnancy potential
不确定情况下的药物决策:考虑慢性病和怀孕的可能性
  • DOI:
    10.1016/j.semperi.2025.152057
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    3.200
  • 作者:
    Mehret Birru Talabi;Rebekah Miller;Tamar Krishnamurti
  • 通讯作者:
    Tamar Krishnamurti
Antirheumatic medications in pregnancy and breastfeeding.
妊娠期和哺乳期的抗风湿药物。
A Framework for Femtech: Guiding Principles for Developing Digital Reproductive Health Tools in the United States
女性科技框架:美国开发数字生殖健康工具的指导原则
  • DOI:
    10.2196/preprints.36338
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    T. Krishnamurti;Mehret Birru Talabi;L. Callegari;T. Kazmerski;S. Borrero
  • 通讯作者:
    S. Borrero
Overturning Roe v. Wade: Toppling the Practice of Rheumatology
推翻罗伊诉韦德案:推翻风湿病学实践
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    13.3
  • 作者:
    B. Bermas;I. Blanco;Ashira Blazer;M. Clowse;C. Edens;R. Ramsey‐Goldman;Mehret Birru Talabi
  • 通讯作者:
    Mehret Birru Talabi

Mehret Birru Talabi的其他文献

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{{ truncateString('Mehret Birru Talabi', 18)}}的其他基金

Time-Sensitive Research to Assess the Effects of Reproductive Health Policy on the Health Outcomes of People with Chronic Diseases
评估生殖健康政策对慢性病患者健康结果影响的时间敏感研究
  • 批准号:
    10768227
  • 财政年份:
    2023
  • 资助金额:
    $ 16.84万
  • 项目类别:
Development of a novel, patient-centered measure of reproductive autonomy in the healthcare context
在医疗保健环境中开发一种新颖的、以患者为中心的生殖自主权测量方法
  • 批准号:
    10508732
  • 财政年份:
    2022
  • 资助金额:
    $ 16.84万
  • 项目类别:
Development of a novel, patient-centered measure of reproductive autonomy in the healthcare context
在医疗保健环境中开发一种新颖的、以患者为中心的生殖自主权测量方法
  • 批准号:
    10670966
  • 财政年份:
    2022
  • 资助金额:
    $ 16.84万
  • 项目类别:
Investigating Pathways to Optimal Reproductive Outcomes Among Women with Rheumatic Diseases
研究患有风湿病的女性获得最佳生殖结果的途径
  • 批准号:
    10263313
  • 财政年份:
    2020
  • 资助金额:
    $ 16.84万
  • 项目类别:
Investigating Pathways to Optimal Reproductive Outcomes Among Women with Rheumatic Diseases
研究患有风湿病的女性获得最佳生殖结果的途径
  • 批准号:
    10478252
  • 财政年份:
    2020
  • 资助金额:
    $ 16.84万
  • 项目类别:
Investigating Pathways to Optimal Reproductive Outcomes Among Women with Rheumatic Diseases
研究患有风湿病的女性获得最佳生殖结果的途径
  • 批准号:
    10054710
  • 财政年份:
    2020
  • 资助金额:
    $ 16.84万
  • 项目类别:

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