Mindfulness and Cognitive Behavioral Therapy for Sleep in Cancer
癌症睡眠的正念和认知行为疗法
基本信息
- 批准号:10686464
- 负责人:
- 金额:$ 0.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-12-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAcute Myelocytic LeukemiaAddressAnxietyBedsBehaviorBehavior TherapyBehavioral SymptomsCancer PatientChronicChronic DiseaseChronic InsomniaClient satisfactionCognitiveCognitive TherapyCombined Modality TherapyCoping SkillsDisease ProgressionDisease remissionDistressExacerbated InsomniaExerciseExpert OpinionFamilyFatigueFocus GroupsFoundationsFutureGoalsHematologic NeoplasmsHomeHospitalizationImmunocompromised HostImmunologic MarkersIndividualInpatientsInterventionLearningLengthLinkLymphoblastic lymphomaMalignant NeoplasmsManualsMeditationMental DepressionMethodologyMindfulness TrainingMissionNappingNational Cancer InstituteNeurosecretory SystemsNon-Hodgkin&aposs LymphomaOutcomePainParticipantPatientsPharmaceutical PreparationsPhasePilot ProjectsPopulationPredisposing FactorProceduresProcessProtocols documentationProviderQuestionnairesRandomizedReportingResearchResearch PersonnelScanningSelf EfficacySeveritiesSleepSleep disturbancesSleeplessnessStandardizationStimulusStructureSurvival RateSymptomsTechniquesTestingThinkingTimeTrainingVulnerable PopulationsWorkacceptability and feasibilityanxiety symptomsarmchemotherapycost effectivedepressive symptomsdisorder riskefficacy trialexperienceheuristicshigh riskimmunosuppressedimprovedinformation gatheringleukemia/lymphomamindfulnessnovel strategiespain symptompharmacologicphase 1 studyphase 2 studypilot testpoor sleeppost interventionprimary outcomeprogramsresponseruminationsatisfactionsecondary outcomeskillssleep difficultysleep patternsleep qualitysymptom managementsymptomatic improvementtheoriestumor progression
项目摘要
Hematologic cancer patients are at high risk for developing insomnia and daytime fatigue, pain, and distress in
the months after inpatient treatment. Extended hospitalization for chemotherapy can activate predisposing
factors (e.g., hyperarousal) and precipitate poor sleep patterns. Lack of sleep and subsequent worry about
poor sleep quality may negatively impact daytime fatigue, pain, and distress, and lead to problematic behaviors
that further exacerbate insomnia (e.g., napping/extended time in bed, medication use). Sleep difficulties can
become chronic as patients struggle to disengage from thoughts about insomnia and its interference to valued
activities. Chronic insomnia places cancer patients at elevated risk for disease progression. Mindfulness-Based
Therapy for Insomnia (MBTI) is new group-based treatment that combines sleep restriction and stimulus
control with mindfulness principles and meditations to treat insomnia, reduce rumination, and promote positive
responses to poor sleep (e.g., less time in bed, less medication). To date, MBTI has not been applied to
hematologic cancer patients who are particularly prone to both nighttime sleep disturbance and daytime
fatigue, pain, and distress in the months following discharge from inpatient chemotherapy. Adaptations to MBTI
are warranted to better address the unique challenges facing immunosuppressed hematologic cancer patients
with insomnia, fatigue, pain, and distress after demanding inpatient treatments. The proposed study seeks to
adapt and assess an MBTI protocol that includes mindfulness-based sleep techniques and training in coping
skills for daytime fatigue, pain, and distress. Participants will be hematologic cancer patients endorsing
insomnia, fatigue, pain, and distress 1-4 weeks after discharge from inpatient chemotherapy. Phase I aims to
use information gathered from patient (N=3) and provider (N=1) focus groups to adapt MBTI for individual
treatment and improved symptom management. Intervention content and procedures will be further refined
through iterative user testing (N=5). We hypothesize these activities will result in a manualized, adapted MBTI
protocol including patient materials and a structured therapist manual to standardize the intervention. Phase II
aims to conduct a single-arm pilot study (N=30) to assess the feasibility, acceptability, and examine pre- to
post-intervention outcomes. We hypothesize that participants will report improvement in the primary outcome
of insomnia symptoms (i.e., severity and interference) and secondary outcomes (i.e., fatigue, pain, anxiety and
depressive symptoms, hyperarousal, mindfulness, and self-efficacy for symptom management). Consistent
with the National Cancer Institute’s mission to reduce suffering from cancer, this project initiates a program of
research focused on critical symptom management needs for the understudied hematologic cancer population.
Positive results from this study would provide support for a larger, methodologically rigorous randomized
efficacy trial. Future work might examine the effects of adapted MBTI on neuroendocrine and immune markers
that are linked to sleep and have implications for cancer progression.
血液学癌症患者出现失眠、日间疲劳、疼痛和焦虑的风险很高
项目成果
期刊论文数量(0)
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Hannah M Fisher其他文献
Hannah M Fisher的其他文献
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{{ truncateString('Hannah M Fisher', 18)}}的其他基金
Mindfulness and Cognitive Behavioral Therapy for Sleep in Cancer
癌症睡眠的正念和认知行为疗法
- 批准号:
10231363 - 财政年份:2021
- 资助金额:
$ 0.25万 - 项目类别:
Mindfulness and Cognitive Behavioral Therapy for Sleep in Cancer
癌症睡眠的正念和认知行为疗法
- 批准号:
10377339 - 财政年份:2021
- 资助金额:
$ 0.25万 - 项目类别:
Mindfulness and Cognitive Behavioral Therapy for Sleep in Cancer
癌症睡眠的正念和认知行为疗法
- 批准号:
10599911 - 财政年份:2021
- 资助金额:
$ 0.25万 - 项目类别:
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