Natural History of Lung Cancer Diagnosed Within and Across Diverse Health Systems Implementing Lung Cancer Screening

项目摘要/摘要 该应用程序的目标是支持硕士尼基·卡罗尔作为研究专家和 科罗拉多州凯撒永久健康研究所的生物统计学家。她支持 在Debra Ritzwoller博士的指导下，癌症和基因组研究核心。的核心是 卡罗尔女士作为研究专家和生物统计学家的多产和成功的职业生涯是在 与癌症相关的治疗模式和结果。这项研究专家奖将允许5名 多年的资金，以维持受保护的时间，让卡罗尔女士专门致力于支持和 领先的癌症研究，旨在产生关于癌症护理的真实证据 在临床试验之外。特别是，她将研究治疗模式和复发风险。 在那些筛查出肺癌的人中，与在国外确诊的肺癌相比 放映。这些结果可能会影响预后评估、治疗选择和未来的试验。 为早期筛查发现的肺制定量身定制的治疗和监测方案 为未来肺癌自然病史的研究奠定了基础 在社区环境中进行筛选。结果将通过当地和 国家会议以及同行评议的期刊手稿。

Project Summary/Abstract The goal of this application is to support Nikki Carroll, MS, as a Research Specialist and Biostatistician at Kaiser Permanente Colorado Institute for Health Research. She supports the Cancer and Genomics Research Core under the direction of Debra Ritzwoller, PhD. The core of Ms. Carroll’s productive and successful career as a Research Specialist and Biostatistician is in cancer related treatment patterns and outcomes. This Research Specialist award would allow 5 years of funding to maintain protected time for Ms. Carroll to work exclusively on supporting and leading cancer research aimed at generating real-world evidence on cancer care that occurs outside of clinical trials. In particular, she will study the treatment patterns and risk of recurrence among those with screen detected lung cancer compared to lung cancers diagnosed outside of screening. These results could impact prognostic estimates, treatment choices, and future trials to develop tailored treatment and surveillance regimens for early-stage, screen-detected lung cancer patients and set the foundation for future studies of the natural history of lung cancer screening in community settings. Results will be broadly disseminated through local and national meetings as well as peer-reviewed journal manuscripts.