Predictors of Influenza-Associated Absenteeism and Impact of Vaccination in a Cohort of Guatemalan Agricultural Workers

项目摘要/摘要 这是一份由医学博士Daniel Olson颁发的以病人为导向的K23指导职业发展奖的申请书。 这项拟议的研究将评估流感的临床和社会经济影响。 危地马拉的农业工人评估流感的临床、生物学和社会经济预测因素- 相关缺勤，并衡量工作场所流感疫苗在减少 疾病和旷工。 候选人。奥尔森博士是一名获得董事会认证的儿科医生和传染病(ID)专家，他是一名助理 科罗拉多大学医学院儿科教授，拥有 科罗拉多公共卫生学院流行病学系的二级职位。 训练。通过实践指导的研究、教学课程和会议/研讨会，奥尔森博士 K23职业发展目标包括：1)培养和形成临床试验设计和培训的技能 实施，2)建立疫苗专业知识，以及3)获得管理和制定 高质量的全球健康研究网站。 导师/环境。奥尔森博士组建了一个不同的导师团队，每个人都有自己的特殊技能 建议的研究和职业发展目标。埃德温·阿斯图利亚斯博士，儿科ID副教授 加州大学的流行病学和社区儿科的朱尔斯·阿梅尔主席将是他的主要导师。这个 其余的导师委员会成员包括Lee Newman博士、Kathryn Edwards博士、May Chu博士和Dr。 Frederick Hayden，提供具有广泛经验和专业知识的不同的高级导师团队。 研究。低收入和中等收入国家继续承受着不成比例的 流行性感冒。工作场所流感疫苗接种计划可能提供一种成本效益高的策略来限制 因流感导致的旷工和生产力损失。农业工人代表着一种经济战略 拉丁美洲的劳动力和流感等与疾病相关的旷工的驱动因素尚不清楚。 CU在危地马拉的研究站点已经建立了一个由2706名农业工人组成的队列，他们来自附近的 香蕉种植园和训练有素的研究团队。为了更好地了解流感对 农业工人和旷工的驱动因素，我们的目标是1)评估临床和社会经济学 流感对危地马拉农业工人队列的影响和确定工作预测因素 2)衡量流感疫苗接种对疾病发病率的有效性， 旷工，以及同一队列中的工作表现。我们假设流感给人类带来了显著的 农业工人的负担，具体的临床、生物和社会经济预测因素可能是 与更多的缺勤有关，以工作场所为基础的流感疫苗计划将显著 减少临床疾病和流感相关旷工。

PROJECT SUMMARY/ABSTRACT This is an application for a K23 Patient-Oriented Mentored Career Development award by Daniel Olson, MD. The proposed research will assess the clinical and socioeconomic impacts of influenza in a cohort of agricultural workers in Guatemala, evaluate clinical, biological, and socioeconomic predictors of influenza- associated absenteeism, and measure the effectiveness of workplace-based influenza vaccine in reducing disease and absenteeism. Candidate. Dr. Olson is a board-certified pediatrician and infectious disease (ID) specialist who is an Assistant Professor in the Department of Pediatrics at the University of Colorado (CU) School of Medicine, with a secondary appointment in the Department of Epidemiology in the Colorado School of Public Health. Training. Through hands-on mentored research, didactic coursework, and conferences/seminars, Dr. Olson’s K23 Career Development aims include: 1) Develop and formalize skills in clinical trial design and implementation, 2) Establish expertise in vaccinology, and 3) Obtain competencies to manage and develop a high quality global health research site. Mentors/Environment. Dr. Olson has assembled a diverse team of mentors, each with specific skills in his proposed research and career development aims. Dr. Edwin Asturias, an Associate Professor of Pediatric ID and Epidemiology at CU and the Jules Amer Chair of Community Pediatrics, will be his primary mentor. The remaining mentorship committee includes Dr. Lee Newman, Dr. Kathryn Edwards, Dr. May Chu, and Dr. Frederick Hayden, providing a diverse group of senior level mentors with broad experience and expertise. Research. Low- and middle-income countries (LMICs) continue to suffer a disproportionate burden of influenza disease. Workplace influenza vaccination programs may offer a cost-effective strategy to limit absenteeism and lost productivity due to influenza. Agricultural workers represent an economically strategic workforce in Latin America, and the drivers of illness-associated absenteeism, such as influenza, are unknown. The CU research site in Guatemala has an established cohort of 2,706 agricultural workers from a nearby banana plantation and a well-trained research team. To better understand the impact of influenza on agricultural workers and the drivers of work absenteeism, we aim to 1) Evaluate the clinical and socioeconomic impacts of influenza on a cohort of Guatemalan agricultural workers and determine predictors of work absenteeism due to influenza, and 2) Measure the effectiveness of influenza vaccination on disease incidence, absenteeism, and job performance in the same cohort. We hypothesize that influenza places a significant burden on agricultural workers, that specific clinical, biological, and socioeconomic predictors may be associated with greater absenteeism, and that a workplace-based influenza vaccine program will significantly reduce clinical disease and influenza-associated absenteeism.