Predictors of Influenza-Associated Absenteeism and Impact of Vaccination in a Cohort of Guatemalan Agricultural Workers

危地马拉农业工人群体中流感相关缺勤的预测因素和疫苗接种的影响

• 批准号: 10686288
• 负责人: Daniel Olson
• 金额: $ 18.64万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10686288
• 关键词: Absenteeism; Acute; Age; Agricultural Workers; Alcoholism; Appointment; Area; Banana; Biological; Biological Markers; Board Certification; Caring; Childhood; Chronic Kidney Failure; Clinic; Clinical; Clinical Data; Clinical Trials Design; Colorado; Communicable Diseases; Communities; Community Health; Competence; Country; Data; Databases; Detection; Disease; Economic Burden; Elderly; Enrollment; Environment; Epidemiology; Future; Genotype; Guatemala; Guatemalan; Health; Healthcare; Human Development; Illness Days; Immunization Programs; Incidence; Income; Individual; Infectious Disease Epidemiology; Influenza; Influenza A Virus, H1N1 Subtype; Influenza vaccination; K-Series Research Career Programs; Laboratories; Latin America; Lead; Longitudinal cohort study; Measurable; Measures; Mediating; Medical; Mentors; Mentorship; Morbidity - disease rate; Nutritional; Onset of illness; Outcome; Outcome Measure; Participant; Pediatrics; Perception; Performance at work; Population; Prediabetes syndrome; Pregnant Women; Production; Productivity; Public Health; Public Health Schools; Quality of life; Recommendation; Registries; Research; Research Training; Risk; Rural; Sampling; Secondary to; Sentinel Surveillance; Serum; Severities; Severity of illness; Site; Specialist; Symptoms; System; Testing; Time; Training; United States; Universities; Vaccination; Vaccines; Vertebral column; Wages; Weight; Work; Workplace; biomarker panel; burden of illness; career development; cohort; comorbidity; cost; cost effective; economic impact; economic outcome; effectiveness evaluation; effectiveness measure; experience; food insecurity; global health; health economics; high risk population; improved; influenza virus strain; influenza virus vaccine; low and middle-income countries; medical schools; mid-career faculty; mortality; novel; pandemic disease; pandemic influenza; patient oriented; pediatric department; pediatrician; population health; professor; programs; prospective; research and development; screening; seasonal influenza; secondary endpoint; skills; socioeconomics; symposium; trend; vaccinology

PROJECT SUMMARY/ABSTRACT This is an application for a K23 Patient-Oriented Mentored Career Development award by Daniel Olson, MD. The proposed research will assess the clinical and socioeconomic impacts of influenza in a cohort of agricultural workers in Guatemala, evaluate clinical, biological, and socioeconomic predictors of influenza- associated absenteeism, and measure the effectiveness of workplace-based influenza vaccine in reducing disease and absenteeism. Candidate. Dr. Olson is a board-certified pediatrician and infectious disease (ID) specialist who is an Assistant Professor in the Department of Pediatrics at the University of Colorado (CU) School of Medicine, with a secondary appointment in the Department of Epidemiology in the Colorado School of Public Health. Training. Through hands-on mentored research, didactic coursework, and conferences/seminars, Dr. Olson’s K23 Career Development aims include: 1) Develop and formalize skills in clinical trial design and implementation, 2) Establish expertise in vaccinology, and 3) Obtain competencies to manage and develop a high quality global health research site. Mentors/Environment. Dr. Olson has assembled a diverse team of mentors, each with specific skills in his proposed research and career development aims. Dr. Edwin Asturias, an Associate Professor of Pediatric ID and Epidemiology at CU and the Jules Amer Chair of Community Pediatrics, will be his primary mentor. The remaining mentorship committee includes Dr. Lee Newman, Dr. Kathryn Edwards, Dr. May Chu, and Dr. Frederick Hayden, providing a diverse group of senior level mentors with broad experience and expertise. Research. Low- and middle-income countries (LMICs) continue to suffer a disproportionate burden of influenza disease. Workplace influenza vaccination programs may offer a cost-effective strategy to limit absenteeism and lost productivity due to influenza. Agricultural workers represent an economically strategic workforce in Latin America, and the drivers of illness-associated absenteeism, such as influenza, are unknown. The CU research site in Guatemala has an established cohort of 2,706 agricultural workers from a nearby banana plantation and a well-trained research team. To better understand the impact of influenza on agricultural workers and the drivers of work absenteeism, we aim to 1) Evaluate the clinical and socioeconomic impacts of influenza on a cohort of Guatemalan agricultural workers and determine predictors of work absenteeism due to influenza, and 2) Measure the effectiveness of influenza vaccination on disease incidence, absenteeism, and job performance in the same cohort. We hypothesize that influenza places a significant burden on agricultural workers, that specific clinical, biological, and socioeconomic predictors may be associated with greater absenteeism, and that a workplace-based influenza vaccine program will significantly reduce clinical disease and influenza-associated absenteeism.

项目总结/文摘

项目成果

Cumulative Febrile, Respiratory, and Gastrointestinal Illness Among Infants in Rural Guatemala and Association With Neurodevelopmental and Growth Outcomes.

危地马拉农村地区婴儿的累积发热、呼吸系统和胃肠道疾病及其与神经发育和生长结果的关系。

• DOI: 10.1097/inf.0000000000004006
• 发表时间: 2023
• 期刊: The Pediatric infectious disease journal
• 作者: Olson,Daniel;Lamb,MollyM;Connery,AmyK;Colbert,AlisonM;Calvimontes,DivaM;Bauer,Desiree;Paniagua-Avila,MAlejandra;Martínez,MaríaAlejandra;Arroyave,Paola;Hernandez,Sara;Colborn,KathrynL;Roell,Yannik;Waggoner,JesseJ;Natrajan,
• 通讯作者: Natrajan,

COVID-19 Attitudes and Vaccine Hesitancy among an Agricultural Community in Southwest Guatemala: A Cross-Sectional Survey.

• DOI: 10.3390/vaccines11061059
• 发表时间: 2023-06-02
• 期刊: Vaccines
• 影响因子: 7.8
• 作者: Rojop N;Calvimontes DM;Barrios E;Lamb MM;Paniagua-Avila A;Monzon J;Duca LM;Iwamoto C;Chard AN;Gomez M;Arias K;Roell Y;Bolanos GA;Zielinski-Gutierrez E;Azziz-Baumgartner E;Lopez MR;Cordon-Rosales C;Asturias EJ;Olson D
• 通讯作者: Olson D