Administering oral vaccines and modulating gastrointestinal immunity using a new physical device

使用新的物理设备注射口服疫苗并调节胃肠道免疫力

• 批准号: nhmrc : 1144167
• 金额: $ 27.82万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/administering-oral-vaccines-physical-device/1320136
• 关键词: Administering; oral; vaccines; modulating; gastrointestinal

Oral vaccination is an ideal delivery route due to its ease of administration, abundance of immune cells in the GI tract and production of protective mucosal immunity at pathogen entry sites. However, its exploitation is limited by delivery challenges such as vaccine degradation in the stomach and poor uptake across mucosa. I will develop a biomedical device which carries and directly delivers vaccines to intestinal mucosa, which ultimately has the potential to replace the needle and syringe.

口服疫苗接种是一种理想的递送途径，因为其易于给药，胃肠道中免疫细胞丰富，并在病原体进入部位产生保护性粘膜免疫。然而，其开发受到递送挑战的限制，例如疫苗在胃中降解和粘膜吸收不良。我将开发一种生物医学设备，它携带并直接将疫苗输送到肠粘膜，最终有可能取代针头和注射器。