HEPA Filtration on Reducing Cardiometabolic Risk During Wildfires

HEPA 过滤可降低野火期间的心脏代谢风险

• 批准号: 10838186
• 负责人: Zhanghua Chen
• 金额: $ 62.09万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10838186
• 关键词: Accounting; Acer; Acute; Address; Adverse effects; Affect; Age; Air; Air Conditioning; Air Pollution; Area; Aromatic Polycyclic Hydrocarbons; Biological Markers; Blood; Blood Pressure; Blood Pressure Monitors; Blood Vessels; Blood specimen; Burn injury; California; Cardiac; Cardiovascular Diseases; Cardiovascular system; Clinical; Coagulation Process; Collection; Country; Cross-Over Trials; Data; Devices; Diagnostic Reagent Kits; Double-Blind Method; Effectiveness; Effectiveness of Interventions; Elderly; Emergency department visit; Enrollment; Epidemic; Event; Exposure to; Filtration; Fire - disasters; Future; Gelatinase B; Health; Health Benefit; Home; Home visitation; Human; Hypertension; Incidence; Individual; Infiltration; Inflammation; Inflammatory; Interdisciplinary Study; Interleukin-6; Intervention; Los Angeles; Measurement; Measures; Mediating; Metabolic; Methods; Modeling; Monitor; Myocardial Ischemia; Noise; Outcome; Participant; Particulate; Patients; Persons; Population; Predisposition; Preventive; Proteomics; Questionnaires; Recording of previous events; Research Design; Risk; Sampling; Seasons; Series; Shelter facility; Smoke; Source; Statistical Data Interpretation; Stress; Surveys; TNF gene; Temperature; Testing; Thrombosis; Time; United States; Urine; VWF gene; Wildfire; aged; air filtration; arm; arterial stiffness; atherothrombosis; behavior change; cardiometabolic risk; cardiometabolism; cardiovascular effects; cardiovascular health; climate change; climate impact; cost; digital; digital health; effectiveness evaluation; epidemiology study; exposed human population; fine particles; follow-up; heart rate variability; improved; indoor air; indoor exposure; insight; novel; prevent; public health relevance; randomized trial; remote monitoring; response; sensor; tool; wearable device; wood smoke

ABSTRACT In this supplemental study, we propose to investigate the climate change effects on health, focusing specifically on the impact of wildland fire-enhanced air pollution on human health. The supplemental study will be built upon the ongoing SAPIA study, "Slowing Atherothrombosis Progression through Indoor Air Filtration," aiming to assess the effectiveness of HEPA filtration in reducing indoor PM2.5 exposure and the subsequent effects on improving atherothrombosis outcomes. The SAPIA study will enroll and follow up 52 participants aged 65-84 years old with ischemic heart disease history and living in the Los Angeles area in year 2023-2024. The aims of this supplemental study will extend the original SAPIA aims to focus on investigating adverse effects of wildfire exposures and assess the effectiveness of residential HEPA filtration in 1) reducing indoor exposure to PM2.5 during wildfire events and 2) alleviating the wildfire-induced adverse effects on acute cardiovascular outcomes (blood pressure, heart rate variability and biomarkers). We will use existing national and regional wildfire and air pollution monitoring networks to monitor wildfire events during the wildfire season (May-September). We will employ low-cost air quality sensors at participants' residential addresses to monitor indoor and outdoor PM2.5 levels. By using both time-series and dispersion models, we will validate the indoor and outdoor levels of wildfire- derived PM2.5 in both HEPA and non-HEPA settings. This approach will enable us to assess the effectiveness of HEPA filtration in reducing indoor PM2.5 concentrations. Once a wildfire event is identified, participants will be informed to complete questionnaires and collect urine and blood samples using pre-distributed and self-collection test kits. Daily blood pressure (BP) and heart rate variability will be remotely collected using Withings BP monitors and wearable Oura® rings. The advantages of this study include the use of a two-arm randomized trial nested within the ongoing SAPIA cross-over trial, wearable digital devices for real-time health monitoring, and self- collection of blood and urine samples, which enable the assessment of the acute health effects of wildfires. Findings of this study will help to assess the effectiveness of HEPA filtration as a preventive tool for the adverse health effects of wildfire-originated air pollution exposure. In conclusion, this supplemental study will contribute significantly to understanding the impact of climate change-enhanced wildfires on human health and the potential health benefits of HEPA filtration by reducing exposure to wildfire-originated PM2.5. By combining state-of-the- art exposure assessment methods, real-time health outcome monitoring and self-collection of biosamples, this study will provide valuable insights into the relationship between wildfire-originated air pollution and cardiovascular health, paving the way for future larger-scale studies in this field.

抽象的 在这项补充研究中，我们建议研究气候变化对健康的影响，专门针对 关于野外火灾增强空气污染对人类健康的影响。补充研究将建立在 正在进行的SAPIA研究，“通过室内空气过滤减慢动脉粥样硬化进展”，目的是 评估HEPA过滤在减少室内PM2.5暴露和随后对的影响方面的有效性 改善动脉粥样硬化结果。 SAPIA研究将注册和跟进52名65-84岁的参与者 2023 - 2024年，患有缺血性心脏病史并居住在洛杉矶地区。目的 这项补充研究将扩大原始SAPIA的目的是专注于研究野火的不利影响 在1）减少室内暴露于PM2.5中的居民HEPA过滤的效果并评估HEPA过滤的有效性 在野火事件和2）减轻野火引起的急性心血管结局的不良影响 （血压，心率变异性和生物标志物）。我们将使用现有的国家和地区野火和空中 在野火季节（5月至9月），污染监测网络以监视野火事件。我们将 参与者居民的低成本空气质量传感器地址，以监视室内和室外PM2.5 水平。通过使用时间序列和分散模型，我们将验证室内和室外水平的野火 在HEPA和非HEPA设置中均得出PM2.5。这种方法将使我们能够评估 HEPA过滤减少室内PM2.5浓度。一旦确定了野火事件，参与者将 通知以完成问卷调查并使用预分配和自我收集收集尿液和血液样本 测试套件。每日血压（BP）和心率变异性将使用withings BP监视器进行远程收集 和可穿戴的outa®环。这项研究的优点包括使用两臂随机试验嵌套 在正在进行的SAPIA交叉试验中，用于实时健康监测的可穿戴数字设备以及自我 血液和尿液样品的收集，可以评估野火的急性健康影响。 这项研究的结果将有助于评估HEPA过滤作为逆境的预防工具的有效性 野火注射空气污染的健康影响。总之，这项补充研究将有助于 显着了解气候变化增强的野火对人类健康的影响 HEPA过滤的健康益处通过减少暴露于野火注射的PM2.5。通过结合最新 艺术暴露评估方法，实时健康结果监测和生物样本的自我收集，此 研究将为野火注射空气污染与 心血管健康，为该领域的未来大规模研究铺平了道路。