Approaches and Outcomes of Shared Decision-making and Patient Centered Care Delivery in Barrett's Esophagus

巴雷特食管的共同决策和以患者为中心的护理服务的方法和结果

基本信息

  • 批准号:
    10688102
  • 负责人:
  • 金额:
    $ 20.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2027-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY This is a resubmission application for a five-year mentored patient-oriented research career development award (K23). The candidate is a motivated clinical researcher at the University of North Carolina Chapel Hill (UNC) with a background in digestive disease epidemiology, a strong publication record, and an established commitment to the study of esophageal diseases, specifically Barrett’s esophagus (BE). The objective of the K23 proposal is to obtain advanced mentored training in patient-oriented research methodologies required to achieve the candidate’s long-term career goal of becoming an independently funded physician-scientist improving detection of esophageal adenocarcinoma (EAC) by implementing patient-centered and shared decision care pathways in BE. Specifically, the candidate’s proposed career development goals are: 1) to obtain training in implementation science and development of patient decision aids; 2) to gain experience in the development of patient-reported outcomes (PRO) measures; 3) to develop knowledge in conducting comparative effectiveness research using large real-world databases; and 4) to transition to independence. To achieve these career development goals, the candidate will 1) take advanced, graduate level coursework in implementation science, decision aid design, PRO measures, and comparative effectiveness research; 2) participate in scholarly activities designed to foster independence and national recognition; and 3) conduct mentored research. The candidate’s mentoring team consists of internationally recognized, independently-funded investigators with expertise in Barrett’s esophagus and gastrointestinal epidemiology (Shaheen), implementation science and decision aids (Reuland), PROs (Keefer) and comparative effectiveness (Lund). Each mentor has a track record of commitment to mentoring junior faculty. The specific aims of the research project are: 1) to develop and test a web-based, patient-directed BE screening decision aid to improve screening rates screen-eligible patients; 2) to develop a BE-specific PRO instrument using in-depth interviews for concept elicitation to generate instrument items and perform cognitive interviews to ensure content validity; 3) to evaluate the comparative effectiveness of endoscopic surveillance versus ablation for BE patients with low-grade dysplasia (LGD) using administrative claims data to aid in shared decision making. Finally, the candidate’s research and training environment at UNC, a preeminent academic research institution, is strong and well-established. For fiscal year 2020, UNC ranked sixteenth for National Institutes of Health (NIH) research funding to domestic institutions of higher education, and has access to NIH funded centers (Translational and Clinical Sciences Institute and Center for Gastrointestinal Biology and Disease) that are tailored to support the proposed studies. This collaborative environment, mentorship, didactics, and research experience will provide the candidate with the strong foundation and unique skillset to successfully achieve the proposed research and training goals. Support from the K23 is critical to achieve the candidate’s goal of transitioning to an independent physician-scientist.
项目摘要 这是一份重新提交的申请,申请为期五年的指导式以病人为导向的研究职业发展奖 (K23)。候选人是北卡罗来纳州查佩尔山大学的一名积极的临床研究人员 具有消化系统疾病流行病学背景,有很强的出版记录, 致力于食管疾病的研究,特别是巴雷特食管(BE)。的目的 K23提案旨在获得以患者为导向的研究方法方面的高级指导培训, 实现候选人的长期职业目标,成为一名独立资助的医生-科学家 通过实施以患者为中心和共享,提高食管腺癌(EAC)的检出率 在BE中的决策护理路径。具体而言,候选人提出的职业发展目标是:1) 获得实施科学和患者决策辅助开发方面的培训; 2)获得 制定患者报告结局(PRO)指标; 3)发展进行比较的知识 使用大型真实世界数据库进行有效性研究;以及4)过渡到独立。实现这些 职业发展目标,候选人将1)采取先进的,研究生水平的课程实施 科学,决策辅助设计,PRO措施和比较有效性研究; 2)参与学术 旨在促进独立性和国家承认的活动;以及3)进行指导研究。的 候选人的指导团队由国际公认的独立资助的调查人员组成, 在巴雷特食管和胃肠道流行病学(沙欣),实施科学和 决策辅助工具(Reuland)、PRO(Keefer)和比较有效性(隆德)。每个导师都有一个跟踪记录 致力于指导初级教师。研究项目的具体目标是:1)开发和测试 基于网络的、患者导向的BE筛查决策辅助工具,以提高筛查合格患者的筛查率; 2) 开发BE专用PRO工具,使用深度访谈进行概念启发,以生成工具 项目和进行认知访谈,以确保内容的效度; 3)评估比较有效性 内镜监测与消融术治疗轻度异型增生(LGD)BE患者的比较, 索赔数据,以帮助共同决策。最后,候选人的研究和培训环境, 作为一个卓越的学术研究机构,该研究所实力雄厚,地位稳固。2020财年, 美国国立卫生研究院(NIH)的研究经费在国内高等院校中排名第16位 教育,并有机会获得NIH资助的中心(转化和临床科学研究所和中心, 胃肠道生物学和疾病),旨在支持拟议的研究。这一协作 环境、导师、教学法和研究经验将为候选人提供强大的 基础和独特的技能,以成功地实现拟议的研究和培训目标。的支持 K23对于实现候选人过渡到独立的医生科学家的目标至关重要。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response.
嗜酸性粒细胞性食管炎与自身免疫和结缔组织疾病的关联以及对治疗反应的影响。
Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
  • DOI:
    10.1016/j.gtc.2022.06.004
  • 发表时间:
    2022-09
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Cotton, Cary C.;Eluri, Swathi;Shaheen, Nicholas J.
  • 通讯作者:
    Shaheen, Nicholas J.
Association between eosinophilic esophagitis and esophageal dysmotility: A systematic review and meta-analysis.
嗜酸性粒细胞性食管炎与食管运动障碍之间的关联:系统评价和荟萃分析。
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Swathi Eluri其他文献

Swathi Eluri的其他文献

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{{ truncateString('Swathi Eluri', 18)}}的其他基金

Approaches and Outcomes of Shared Decision-making and Patient Centered Care Delivery in Barrett's Esophagus
巴雷特食管的共同决策和以患者为中心的护理服务的方法和结果
  • 批准号:
    10525554
  • 财政年份:
    2022
  • 资助金额:
    $ 20.03万
  • 项目类别:

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