Approaches and Outcomes of Shared Decision-making and Patient Centered Care Delivery in Barrett's Esophagus

巴雷特食管的共同决策和以患者为中心的护理服务的方法和结果

• 批准号: 10688102
• 负责人: Swathi Eluri
• 金额: $ 20.03万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10688102
• 关键词: Ablation; Affect; American; Anxiety; Award; Awareness; Barrett Esophagus; Biology; Caring; Clinical; Clinical Investigator; Clinical Sciences; Comparative Effectiveness Research; Cost of Illness; Data; Databases; Decision Aid; Detection; Development; Digestive System Disorders; Disease; Dysplasia; Early Diagnosis; Eligibility Determination; Endoscopy; Ensure; Environment; Epidemiology; Esophageal Adenocarcinoma; Esophageal Diseases; Faculty; Fostering; Foundations; Funding; Funding Opportunities; Future; Gastroenterology; Generations; Goals; High grade dysplasia; Incidence; Institution; International; Interview; Knowledge; Malignant Neoplasms; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Modality; North Carolina; Online Systems; Outcome; Outcome Measure; Pathway interactions; Patient Outcomes Assessments; Patient-Centered Care; Patient-Focused Outcomes; Patients; Phase; Physicians; Prevention; Publications; Qualitative Research; Quality of life; Randomized, Controlled Trials; Research; Research Methodology; Research Personnel; Research Project Grants; Scientist; Standardization; Survival Rate; Symptoms; Teacher Professional Development; Testing; Training; Translational Research; Treatment outcome; United States; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; administrative database; cancer risk; care delivery; career; career development; cognitive interview; collaborative environment; comparative effectiveness; comparative effectiveness study; design; experience; gastrointestinal; high risk; higher education; implementation science; improved; instrument; interest; large datasets; patient oriented; patient oriented research; patient population; patient-clinician communication; personalized care; preference; prevent; psychosocial; research and development; screening; shared decision making; skill acquisition; skills; tool

PROJECT SUMMARY This is a resubmission application for a five-year mentored patient-oriented research career development award (K23). The candidate is a motivated clinical researcher at the University of North Carolina Chapel Hill (UNC) with a background in digestive disease epidemiology, a strong publication record, and an established commitment to the study of esophageal diseases, specifically Barrett’s esophagus (BE). The objective of the K23 proposal is to obtain advanced mentored training in patient-oriented research methodologies required to achieve the candidate’s long-term career goal of becoming an independently funded physician-scientist improving detection of esophageal adenocarcinoma (EAC) by implementing patient-centered and shared decision care pathways in BE. Specifically, the candidate’s proposed career development goals are: 1) to obtain training in implementation science and development of patient decision aids; 2) to gain experience in the development of patient-reported outcomes (PRO) measures; 3) to develop knowledge in conducting comparative effectiveness research using large real-world databases; and 4) to transition to independence. To achieve these career development goals, the candidate will 1) take advanced, graduate level coursework in implementation science, decision aid design, PRO measures, and comparative effectiveness research; 2) participate in scholarly activities designed to foster independence and national recognition; and 3) conduct mentored research. The candidate’s mentoring team consists of internationally recognized, independently-funded investigators with expertise in Barrett’s esophagus and gastrointestinal epidemiology (Shaheen), implementation science and decision aids (Reuland), PROs (Keefer) and comparative effectiveness (Lund). Each mentor has a track record of commitment to mentoring junior faculty. The specific aims of the research project are: 1) to develop and test a web-based, patient-directed BE screening decision aid to improve screening rates screen-eligible patients; 2) to develop a BE-specific PRO instrument using in-depth interviews for concept elicitation to generate instrument items and perform cognitive interviews to ensure content validity; 3) to evaluate the comparative effectiveness of endoscopic surveillance versus ablation for BE patients with low-grade dysplasia (LGD) using administrative claims data to aid in shared decision making. Finally, the candidate’s research and training environment at UNC, a preeminent academic research institution, is strong and well-established. For fiscal year 2020, UNC ranked sixteenth for National Institutes of Health (NIH) research funding to domestic institutions of higher education, and has access to NIH funded centers (Translational and Clinical Sciences Institute and Center for Gastrointestinal Biology and Disease) that are tailored to support the proposed studies. This collaborative environment, mentorship, didactics, and research experience will provide the candidate with the strong foundation and unique skillset to successfully achieve the proposed research and training goals. Support from the K23 is critical to achieve the candidate’s goal of transitioning to an independent physician-scientist.

项目总结

项目成果

Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response.

嗜酸性粒细胞性食管炎与自身免疫和结缔组织疾病的关联以及对治疗反应的影响。

• DOI: 10.1093/dote/doac043
• 发表时间: 2022
• 期刊: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
• 作者: Xue,Zeyun;Miller,TalyaL;Abramson,Lior;Thakkar,KisanP;Ketchem,CoreyJ;Reddy,Sumana;Greenberg,SydneyB;Abichandani,Sonia;Chang,NicoleC;Eluri,Swathi;Reed,CraigC;Dellon,EvanS
• 通讯作者: Dellon,EvanS

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.

• DOI: 10.1016/j.gtc.2022.06.004
• 发表时间: 2022-09
• 期刊: GASTROENTEROLOGY CLINICS OF NORTH AMERICA
• 影响因子: 3.7
• 作者: Cotton, Cary C.;Eluri, Swathi;Shaheen, Nicholas J.
• 通讯作者: Shaheen, Nicholas J.

Association between eosinophilic esophagitis and esophageal dysmotility: A systematic review and meta-analysis.

嗜酸性粒细胞性食管炎与食管运动障碍之间的关联：系统评价和荟萃分析。

• DOI: 10.1111/nmo.14475
• 发表时间: 2023
• 期刊: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
• 作者: Reddy,SumanaB;Ketchem,CoreyJ;Dougherty,MichaelK;Eluri,Swathi;Dellon,EvanS
• 通讯作者: Dellon,EvanS