Approaches and Outcomes of Shared Decision-making and Patient Centered Care Delivery in Barrett's Esophagus

巴雷特食管的共同决策和以患者为中心的护理服务的方法和结果

基本信息

批准号：
10688102
负责人：
Swathi Eluri
金额：
$ 20.03万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10688102
关键词：
Ablation Affect American Anxiety Award Awareness Barrett Esophagus Biology Caring Clinical Clinical Investigator Clinical Sciences Comparative Effectiveness Research Cost of Illness Data Databases Decision Aid Detection Development Digestive System Disorders Disease Dysplasia Early Diagnosis Eligibility Determination Endoscopy Ensure Environment Epidemiology Esophageal Adenocarcinoma Esophageal Diseases Faculty Fostering Foundations Funding Funding Opportunities Future Gastroenterology Generations Goals High grade dysplasia Incidence Institution International Interview Knowledge Malignant Neoplasms Measures Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Modality North Carolina Online Systems Outcome Outcome Measure Pathway interactions Patient Outcomes Assessments Patient-Centered Care Patient-Focused Outcomes Patients Phase Physicians Prevention Publications Qualitative Research Quality of life Randomized, Controlled Trials Research Research Methodology Research Personnel Research Project Grants Scientist Standardization Survival Rate Symptoms Teacher Professional Development Testing Training Translational Research Treatment outcome United States United States Agency for Healthcare Research and Quality United States National Institutes of Health Universities administrative database cancer risk care delivery career career development cognitive interview collaborative environment comparative effectiveness comparative effectiveness study design experience gastrointestinal high risk higher education implementation science improved instrument interest large datasets patient oriented patient oriented research patient population patient-clinician communication personalized care preference prevent psychosocial research and development screening shared decision making skill acquisition skills tool

项目摘要

PROJECT SUMMARY This is a resubmission application for a five-year mentored patient-oriented research career development award (K23). The candidate is a motivated clinical researcher at the University of North Carolina Chapel Hill (UNC) with a background in digestive disease epidemiology, a strong publication record, and an established commitment to the study of esophageal diseases, specifically Barrett’s esophagus (BE). The objective of the K23 proposal is to obtain advanced mentored training in patient-oriented research methodologies required to achieve the candidate’s long-term career goal of becoming an independently funded physician-scientist improving detection of esophageal adenocarcinoma (EAC) by implementing patient-centered and shared decision care pathways in BE. Specifically, the candidate’s proposed career development goals are: 1) to obtain training in implementation science and development of patient decision aids; 2) to gain experience in the development of patient-reported outcomes (PRO) measures; 3) to develop knowledge in conducting comparative effectiveness research using large real-world databases; and 4) to transition to independence. To achieve these career development goals, the candidate will 1) take advanced, graduate level coursework in implementation science, decision aid design, PRO measures, and comparative effectiveness research; 2) participate in scholarly activities designed to foster independence and national recognition; and 3) conduct mentored research. The candidate’s mentoring team consists of internationally recognized, independently-funded investigators with expertise in Barrett’s esophagus and gastrointestinal epidemiology (Shaheen), implementation science and decision aids (Reuland), PROs (Keefer) and comparative effectiveness (Lund). Each mentor has a track record of commitment to mentoring junior faculty. The specific aims of the research project are: 1) to develop and test a web-based, patient-directed BE screening decision aid to improve screening rates screen-eligible patients; 2) to develop a BE-specific PRO instrument using in-depth interviews for concept elicitation to generate instrument items and perform cognitive interviews to ensure content validity; 3) to evaluate the comparative effectiveness of endoscopic surveillance versus ablation for BE patients with low-grade dysplasia (LGD) using administrative claims data to aid in shared decision making. Finally, the candidate’s research and training environment at UNC, a preeminent academic research institution, is strong and well-established. For fiscal year 2020, UNC ranked sixteenth for National Institutes of Health (NIH) research funding to domestic institutions of higher education, and has access to NIH funded centers (Translational and Clinical Sciences Institute and Center for Gastrointestinal Biology and Disease) that are tailored to support the proposed studies. This collaborative environment, mentorship, didactics, and research experience will provide the candidate with the strong foundation and unique skillset to successfully achieve the proposed research and training goals. Support from the K23 is critical to achieve the candidate’s goal of transitioning to an independent physician-scientist.

项目摘要这是为期五年的指导患者研究职业发展奖的重新提交申请（K23）。候选人是北卡罗来纳大学教堂山（UNC）的成熟临床研究员具有消化疾病流行病学的背景，强大的出版记录和已建立的对食管疾病的研究，特别是巴雷特的食管（BE）。目的 K23的建议是获得所需的以患者为导向的研究方法的高级培训实现候选人的长期职业目标，即成为独立资助的身体科学家通过实施以患者为中心和共享的食管腺癌（EAC）的检测 BE的决策护理途径。特别是，候选人提出的职业发展目标是：1）获得实施科学培训和患者决策艾滋病的发展； 2）在开发患者报告的结果（PRO）措施； 3）发展进行比较的知识使用大型现实世界数据库的有效研究； 4）过渡到独立。实现这些职业发展目标，候选人将1）参加实施的高级研究生课程科学，决策援助设计，专业测量和比较有效性研究； 2）参与科学旨在促进独立和民族认可的活动； 3）进行指导研究。这候选人的心理团队由国际认可的，独立资助的调查员组成 Barrett的食道和胃肠道流行病学（Shaheen），实施科学和决策艾滋病（Reuland），专业人士（Keefer）和比较有效性（LUND）。每个精神都有记录致力于初级教师的承诺。研究项目的具体目的是：1）开发和测试基于Web的患者指导的是筛选决策辅助，以提高筛查率符合筛查资格的患者； 2）使用深入的访谈来开发特定的专业仪器以生成仪器的概念启发项目并进行认知访谈以确保内容有效性； 3）评估比较有效性使用行政管理的患有低度发育不良（LGD）的患者的内窥镜监视与消融索赔数据以帮助共享决策。最后，候选人在杰出的学术研究机构UNC既强大又建立了公认。在2020财政年度，UNC 美国国立卫生研究院（NIH）的研究资金排名第16位教育，并可以进入NIH资助的中心（转化和临床科学研究所和中心胃肠道生物学和疾病）是为支持拟议研究而定制的。这个合作环境，精神训练，教学和研究经验将为候选人提供强大的基础和独特的技能，以成功实现拟议的研究和培训目标。支持 K23对于实现候选人将过渡到独立身体科学家的目标至关重要。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Association of eosinophilic esophagitis with autoimmune and connective tissue disorders, and the impact on treatment response.

嗜酸性粒细胞性食管炎与自身免疫和结缔组织疾病的关联以及对治疗反应的影响。

DOI：
10.1093/dote/doac043
发表时间：
2022
期刊：
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
影响因子：
0
作者：
Xue,Zeyun;Miller,TalyaL;Abramson,Lior;Thakkar,KisanP;Ketchem,CoreyJ;Reddy,Sumana;Greenberg,SydneyB;Abichandani,Sonia;Chang,NicoleC;Eluri,Swathi;Reed,CraigC;Dellon,EvanS
通讯作者：
Dellon,EvanS

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.

DOI：
10.1016/j.gtc.2022.06.004
发表时间：
2022-09
期刊：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
影响因子：
3.7
作者：
Cotton, Cary C.;Eluri, Swathi;Shaheen, Nicholas J.
通讯作者：
Shaheen, Nicholas J.

Association between eosinophilic esophagitis and esophageal dysmotility: A systematic review and meta-analysis.

嗜酸性粒细胞性食管炎与食管运动障碍之间的关联：系统评价和荟萃分析。

DOI：
10.1111/nmo.14475
发表时间：
2023
期刊：
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
影响因子：
0
作者：
Reddy,SumanaB;Ketchem,CoreyJ;Dougherty,MichaelK;Eluri,Swathi;Dellon,EvanS
通讯作者：
Dellon,EvanS