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mRNA vaccine responses in PLWH

PLWH 中的 mRNA 疫苗反应

基本信息

批准号：
10687989
负责人：
JOEL N BLANKSON
金额：
$ 20.47万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-22 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10687989
关键词：
2019-nCoV Affinity Antibodies Antibody Response Antibody titer measurement Antigens Avidity Binding CD4 Positive T Lymphocytes COVID-19 COVID-19 vaccination Clonal Expansion Coin Common Cold Coronavirus Coronavirus Infections Data Development Future General Population Immunization Immunize Individual Infection Influenza A Virus, H1N1 Subtype Lymphocyte Memory Memory B-Lymphocyte Messenger RNA Outcome Patients Peptides Policies RNA vaccination RNA vaccine Respiratory Disease SARS-CoV-2 B.1.1.7 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 immunity SARS-CoV-2 spike protein T cell response T memory cell T-Lymphocyte T-cell receptor repertoire Testing Upper Respiratory Infections Vaccinated Vaccination Vaccines Variant Virus booster vaccine coronavirus disease cross reactivity efficacy evaluation human coronavirus influenza virus strain mortality pathogen phrases receptor response seroconversion vaccine efficacy vaccine response variants of concern

项目摘要

Project Summary Two mRNA COVID vaccines that have greater than 90% efficacy in healthy donors have been developed. However the efficacy of these vaccines in PLWH is unknown. PLWH have had suboptimal responses to some prior vaccines potentially because they make limited naïve T cell responses. We and others have shown T cell cross-recognition of spike proteins from SARS-CoV-2 and the common cold coronavirus and demonstrated that these cross-reactive responses are less effective against SARS-CoV-2 than mono- reactive responses. We hypothesize that cross-reactive memory responses will contribute more towards the total SARS-CoV-2 responses in PLWH than in healthy donors and this will result in less effective responses to the mRNA vaccines. We will test this hypothesis by comparing CD4+ T cell and antibody responses in vaccinated healthy donors and PLWH. Our results will have major implications for future policies regarding booster shots for PLWH and the general population

项目摘要两种mRNA COVID疫苗在健康供体中的有效性超过90%，开发了然而，这些疫苗在PLWH中的功效尚不清楚。PLWH 对一些先前的疫苗没有最佳的反应，可能是因为它们使有限的幼稚T细胞反应。我们和其他人已经证明T细胞交叉识别 SARS-CoV-2和普通感冒冠状病毒的刺突蛋白，这些交叉反应对SARS-CoV-2的有效性低于单一反应，反应性反应。我们假设交叉反应性记忆反应 PLWH中SARS-CoV-2的总应答率高于健康人，这将导致对mRNA疫苗的有效应答降低。我们将测试通过比较接种疫苗的健康人中的CD 4 + T细胞和抗体应答，捐助者和艾滋病毒携带者。我们的研究结果将对未来的政策产生重大影响，艾滋病毒携带者和一般人群的加强注射