Multi-Scale Multi-Modality High Resolution Mapping of the Adult Human Lung

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Project Summary/Abstract Data Analysis Core Synthesis of the Multimodality High Resolution 3-D Atlas of Human Lung The Data Analysis Core (DAC) is responsible for all aspects of data and metadata management, processing, analysis, mapping, and sharing for this Tissue Mapping Center (TMC) and of the Organ Specific Project focused on the adult healthy human lung (i.e., Lung Specific Project or LSP). We will take a long view of an Atlas, as a collection of 2D and 3D maps containing images, tabular data, facts about multiple locations at varying resolution and indexes of named objects keyed to coordinates of a locational grid analogous to latitude and longitude, to cartographically present the whole range of salient features of the human Lung. The DAC will support the TMC in these activities by providing a protected environment for data storage and computation, and by developing robust reproducible, reusable, and scalable computational workflows thus enabling the integration of data types into 3D maps for the purpose of creating an interactive and queryable biomolecular human atlas. The DAC is an essential part of the TMC in its objectives to produce and deliver to the HIVE extensive sets of high-resolution spatial mappings of molecular entities, using open formats, and within the context of the cellular and extracellular organization of the Lung. The DAC will accomplish its role through the following Specific Aims: 1) Ingest and process TMC datasets, 2) Analyze datasets in support of generating multiscale, multiparameter lung tissue maps, tabular data, and annotations, 3) Construct 2D and 3D lung tissue maps with integrated datasets and 4) Coordinate planning and atlas production with the HuBMAP Consortium.