Administrative Core

项目摘要/摘要 大分子之间的信息传递是在分子水平上定义生命的一个方面 对所有的体内平衡和疾病过程都是至关重要的。内布拉斯加州集成生物分子中心 传播(CIBC)促进了专注于空间和时间方面的跨学科研究 使用跨越从分子到组织的连续体的方法的生物分子通信 级别。CIBC通过自主开发，显著增加了内布拉斯加州的生物医学研究专业知识 资助对复杂疾病进行高影响力研究的跨学科研究合作 从不同的角度来看。行政核心在第二阶段的目标是继续提供总体 协调和行政基础设施，使CIBC能够继续发展跨学科 了解与生物医学相关的监管所需的生物医学专业知识和方法 沟通途径。具体目标是：1)提供科学性、管理性和纲领性 需要领导和研究基础设施，以确保CIBC运营有效和高效地运作，并 支持中心总体目标和具体目标的进展，2)协调强有力的指导和 促进早期研究人员和他们的研究和职业发展的发展计划 过渡到独立调查员身份，3)支持和扩大一套全中心范围的浓缩活动 为创造协作研究环境，为CIBC成员提供有意义的互动机会 并促进一条明确的途径，通过这条途径，更多的教员、博士后研究助理、 研究生和本科生将加入该中心；以及4)支持CIBC的最终过渡 通过支持中心成员的安全计划成为自给自足的生物医学研究卓越中心 项目赠款；大规模多名调查员赠款；个别调查员项目；以及培训赠款。通过 为了实现这些目标，管理核心将支持加拿大帝国商业银行的核心目标：1)支持增长 内布拉斯加州大学的生物医学研究基础设施和2)促进对 调节与生物医学相关的通信路径并开发干预措施以检测、 预防和治疗疾病，改善更广泛人口的健康结果。

PROJECT SUMMARY/ABSTRACT The transfer of information between macromolecules is one of the defining aspects of life at the molecular level and is critical for all homeostatic and disease processes. The Nebraska Center for Integrated Biomolecular Communication (CIBC) fosters interdisciplinary research focused on spatial and temporal aspects of biomolecular communication using approaches that span a continuum ranging from the molecular to the tissue levels. CIBC has significantly increased biomedical research expertise in Nebraska by developing independently funded interdisciplinary research collaborations that are pursuing high impact research into complex diseases from diverse perspectives. The goal of the Administrative Core in Phase 2 is to continue to provide the overall coordination and administrative infrastructure that will enable CIBC to continue growing the interdisciplinary biomedical expertise and approaches needed to understand the regulation of biomedically relevant communication pathways. The specific aims are: 1) provide the scientific, administrative, and programmatic leadership and research infrastructure needed to ensure CIBC operations function effectively and efficiently and support progress toward the Center’s overall goals and specific aims, 2) coordinate a strong mentoring and development plan to catalyze the research and career development of early stage investigators and their transition to independent investigator status, 3) support and expand a suite of Center-wide enrichment activities to create a collaborative research environment, provide meaningful opportunities for CIBC members to interact with one another, and promote a clear pathway by which additional faculty, postdoctoral research associates, and graduate and undergraduate students will affiliate with the Center; and 4) support CIBC’s eventual transition to a self-sustaining center of biomedical research excellence by supporting Center members in securing program project grants; large-scale, multi-investigator grants; individual investigator projects; and training grants. By accomplishing these aims, the Administrative Core will support CIBC’s central goals of 1) supporting the growth of biomedical research infrastructure at the University of Nebraska and 2) advancing the understanding of the regulation of biomedically relevant communication pathways and the development of interventions to detect, prevent, and treat disease, improving health outcomes among the broader population.