Neuronal Avalanches in the Neocortex

新皮质中的神经元雪崩

• 批准号: 10703916
• 负责人: Dietmar Plenz
• 金额: $ 243.43万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10703916
• 关键词: Action Potentials; Animals; Architecture; Biological Markers; Brain; Clinical Data; Cognition; Communication; Complex; Development; Diagnosis; Disease; Equilibrium; Goals; Human; International; Intramural Research Program; Laboratories; Mediating; Mental disorders; Monitor; Monkeys; Movement; Neocortex; Neurons; Neurosciences; Perception; Phase Transition; Physics; Population; Preparation; Publishing; Research; Rest; Rodent; Role; System; Technology; Time; Translational Research; United States National Institutes of Health; Work; awake; base; brain abnormalities; information processing; insight; interdisciplinary approach; large datasets; nervous system disorder; research study; spatiotemporal; theories

1. We demonstrated for the first time that the specific and unique brain architecture formed by neuronal avalanches is stable over many weeks and months. The findings obtained with advanced multielectrode technology demonstrate avalanches to represent an overarching principle of brain activity despite ongoing developmental and other related plasticity changes. Miller et al., 2021 2. We published a comprehensive review on the experimental evidence provided by numerous groups over the last 20 years on self-organized criticality in the brain. This review demonstrates that the most robust signature of self-organized criticality in the form of neuron avalanches arises in so-called superficial cortical layers of the mammalian brain. Accordingly, brain preparations that do not include superficial layers do not show robust signatures of criticality. This review provides an important guide for future research with respect to potential experimental pitfalls in criticality research. Plenz et al., 2021 3. We provided a comprehensive review on how collective phenomena in the brain and in animal groups share common theoretical aspects such as the presence of so-called phase transition. This review for the first time provides an important bridge between numerous, diverse fields of research studying the robust present and potential advantage of collective dynamics. Lins-Ribeiro et al., 2021.

1.我们首次证明了由神经元雪崩形成的特定和独特的大脑结构在数周和数月内是稳定的。 利用先进的多电极技术获得的研究结果表明，雪崩代表了大脑活动的总体原则，尽管正在进行发育和其他相关的可塑性变化。 米勒等人，2021 2.我们发表了一份关于过去20年来许多小组提供的关于大脑自组织临界性的实验证据的全面评论。 这篇评论表明，最强大的签名的自组织临界神经元雪崩的形式出现在所谓的哺乳动物大脑的表层皮层。 因此，不包括表面层的脑制备物不显示出临界性的稳健特征。 这篇评论为未来的研究提供了重要的指导，就潜在的实验陷阱在临界研究。 Plenz等人，2021 3.我们对大脑和动物群体中的集体现象如何共享共同的理论方面进行了全面的回顾，例如所谓的相变的存在。 这篇评论第一次提供了一个重要的桥梁之间的众多，不同的研究领域研究强大的集体动力学的现状和潜在的优势。 Lins-Ribeiro等人，2021.