Clinical Research and Protocol Support Services

临床项目由临床主任http://www.nei.nih.gov/intramural/cbranch.asp办公室集中管理，该办公室由一家最先进的门诊设施和一支由眼科医生、眼科成像师、眼科技术人员和临床研究协调员组成的多学科团队组成，所有这些人都拥有支持临床研究的高技能和训练有素的人员。 临床主任办公室继续在临床研究方案审批过程的所有阶段为国家眼科研究所的研究员提供核心临床研究服务支持，从概念到CNS-IRB的批准，直到完成。这项支持包括诊断、统计、方案设计、协调、监管、管理和临床设施，使NEI临床研究人员能够将他们的时间和资源集中在开发和进行创新性和高风险临床研究上。这种支持平均涵盖40个以上的活动协议。有关NEI内部科学资料包的完整描述，请访问http://www.nei.nih.gov/intramural/.。在马里兰州贝塞斯达的沃伦·格兰特·马格努森临床中心正在进行的特定NEI临床试验可在http://clinicalstudies.info.nih.gov/cgi/protinstitute.cgi?NEI.0.html上找到，其中包括：成像/诊断、糖尿病黄斑水肿、白内障和视觉运动障碍；针对视网膜血管和遗传性眼病的营养、药物和/或基因疗法；以及针对老年性黄斑变性的新生血管的激光治疗方法和补充方法。 此外，临床主任办公室还向NIH社区提供眼科咨询服务。这些会诊提供了罕见病理的有趣组合，例如：神经囊虫病(NIAID)、转移性黑色素瘤-一种伴有自身免疫性眼部炎症(NCI)的疾病、移植物抗宿主病伴眼部受累(NHLBI)和韦格纳肉芽肿病(NIAID)，它促进了长期的合作并导致了临床试验和额外的研究。

The clinical program is centrally managed by the Office of the Clinical Director http://www.nei.nih.gov/intramural/cbranch.asp which consists of a state-of-the-art outpatient facility and a multidisciplinary team of ophthalmic physicians, ophthalmic imagers, ophthalmic technicians, and clinical research coordinators, all highly skilled and trained to support clinical research. The Office of the Clinical Director continues to provide core clinical research service support to National Eye Institute investigator during all phases of the clinical research protocol approvals process from concept to approval by the CNS-IRB and until completion. This supports includes; diagnostic, statistical, protocol design, coordinating, regulatory, management, and clinical facilites that enable NEI clinical investigators to focus their time and resourses on developing and conducting inovative and high risk clinical research. This support covered, on average, 40 plus active protocols. A complete description of NEI's intramural scientific portfolio can be found at http://www.nei.nih.gov/intramural/. Specific NEI clinical trials being conducted at the Warren Grant Magnuson Clinical Center in Bethesda, Maryland can be found at http://clinicalstudies.info.nih.gov/cgi/protinstitute.cgi?NEI.0.html and include among others: imaging/diagnostic, diabetic macular edema, cataract, and vision motor disorders; nutritional, pharmacologic, and/or gene therapies for retinal vascular and genetically-inherited ocular diseases; and laser approaches and supplemental methodologies for neovascularization in age-related macular degeneration. In addition the Office of the Clinical Director provides ophthalmic consult services to the NIH community. These consultations provide an interesting mix of rare pathologies such as: neurocysticercosis (NIAID), metastatic melanoma-a disease with autoimmune ocular inflammation (NCI), graft versus host disease with ocular involvement (NHLBI), and Wegener's granulomatosis (NIAID) which has fosterd longterm collaborations and has lead to clinical trials and additional investigations.