A Career Development Award in Global Postpartum Health

全球产后健康职业发展奖

• 批准号: 10706338
• 负责人: Mae Bridget Spelke
• 金额: $ 18.45万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706338
• 关键词: Adherence; Administrator; Adoption; Africa South of the Sahara; African; Agreement; Area; Attention; Blood Pressure; Characteristics; Child; Childbirth; Clinical Research; Clinical Trials; Clinical Trials Design; Cohort Studies; Country; Data; Discipline of obstetrics; Education; Eligibility Determination; Ensure; Epidemiology; Equity; Evaluation; Family; Fogarty International Center; Foundations; Frequencies; Future; Goals; Gynecologist; Health; Health Services Accessibility; Health Technology; Heart Rate; Hemorrhage; Home; Hospitals; Hour; Hypertension; Income; Infant; International; Intervention; Intervention Trial; Investigation; K-Series Research Career Programs; Learning; Life; Maintenance; Maternal Health; Maternal Mortality; Maternal-fetal medicine; Measures; Medical Records; Mentored Research Scientist Development Award; Mentors; Mentorship; Modeling; Modification; Monitor; Morbidity - disease rate; North Carolina; Outcome; Oxygen; Participant; Patient Monitoring System; Patients; Physiologic Monitoring; Physiologic pulse; Physiological; Policy Maker; Population; Postpartum Period; Postpartum Programs; Postpartum Women; Pregnancy; Pregnant Women; Premature Birth; Prevention; Procedures; Prospective cohort; Protocols documentation; Provider; Proxy; Qualifying; Qualitative Evaluations; Randomized; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Recommendation; Research; Research Personnel; Resource-limited setting; Resources; Risk; Risk Factors; Sample Size; Sepsis; Series; Solid; System; Technology; Temperature; Time; Training; Universities; Woman; Women' s Health; Zambia; adverse birth outcomes; antenatal; blood pressure control; care delivery; care outcomes; career; career development; clinical epidemiology; clinical phenotype; clinical trial implementation; cohort; design; digital; digital health; effectiveness/implementation trial; experience; feasibility trial; follow-up; future implementation; global health; health application; high risk; hospital readmission; implementation framework; implementation research; implementation science; improved; improved outcome; intrapartum; lifetime risk; maternal morbidity; monitoring device; neglect; novel strategies; obstetric outcomes; post implementation; postpartum care; postpartum complications; postpartum health; postpartum outcome; prevent; programs; randomized trial; remote monitoring; respiratory; sensor; severe maternal morbidity; skills; uptake; wearable sensor technology; wireless sensor

ABSTRACT A Career Development Award in Global Postpartum Health This application is for a Fogarty International Center K01 International Research Scientist Development Award (IRSDA) for Dr. Bridget Spelke, MD, an obstetrician-gynecologist and research fellow in Global Women's Health at the University of North Carolina (UNC). Dr. Spelke is in the formative stages of her research career and aims to establish herself as an independent investigator and future leader in the area of global postpartum health, a high-risk period that has been neglected for too long. She has lived full-time in Lusaka, Zambia since August 2019 where she has established a solid career foundation for clinical research in obstetric outcomes for women in resource-constrained settings. Dr. Spelke's proposed K01 research will leverage a recent expansion of the Zambian Preterm Birth Prevention Study (ZAPPS), a long-standing pregnancy cohort that is following women and their infants through 12 months postpartum. Dr. Spelke will study a novel strategy to identify women at risk for severe maternal morbidity and mortality in the first week after delivery: continuous remote physiologic monitoring with easy-to-use, multiparameter, wearable sensors. To inform the design of a future hybrid effectiveness-implementation trial, Dr. Spelke proposes a mentored research program that will estimate the frequency of severe maternal morbidity in the ZAPPS cohort (Aim 1); implement a pilot randomized feasibility trial of postpartum physiologic monitoring (Aim 2); and evaluate barriers and facilitators to adoption of a digital health intervention in a resource-constrained setting through implementation research frameworks (Aim 3). These three research aims will provide preliminary data toward the design of a future trial. They are interrelated and independent of each other; study results will advance research on digital and postpartum health in resource- constrained settings regardless of outcomes. Each of these studies aligns with individualized career development goals in clinical trials design and analysis, implementation research for digital health technologies, and collaborative global health research partnerships. Dr. Spelke has assembled a highly accomplished and eminently qualified mentorship team comprising: her primary Zambia mentor, Prof. Bellington Vwalika, an expert in clinical trials implementation in sub-Saharan Africa; her primary US mentor, Prof. Elizabeth Stringer, an expert in maternal-fetal medicine and maternal health epidemiology; and her core mentor, Prof. Ben Chi, an expert in implementation science in sub-Saharan Africa. All three mentors have decades of experience in collaborative global health partnerships and extensive experience mentoring early career researchers. The IRSDA will advance Dr. Spelke's skills in each of these fields, supporting both didactic and practice-based learning opportunities, as she establishes her independent area of investigation and progresses towards research independence in global postpartum health.

摘要 全球产后健康职业发展奖 此应用程序是一个福格蒂国际中心K 01国际研究科学家发展奖 （IRSDA）为布里奇特斯佩尔克博士，医学博士，妇产科医生和研究员在全球妇女健康 在北卡罗来纳州大学（北卡罗莱纳州）。Spelke博士正处于研究生涯的形成阶段， 为了使自己成为全球产后健康领域的独立研究者和未来领导者， 长期以来被忽视的高风险时期。自8月以来，她一直全职居住在赞比亚的卢萨卡 2019年，她为女性产科结局的临床研究奠定了坚实的职业基础 在资源有限的情况下。Spelke博士提出的K 01研究将利用最近的扩展， 赞比亚早产预防研究（ZAPPS），一项长期的妊娠队列研究， 以及产后12个月的婴儿。斯佩尔克博士将研究一种新的策略，以确定妇女的风险 对于产后第一周内严重的孕产妇发病率和死亡率：持续远程生理 通过易于使用的多参数可穿戴传感器进行监测。为未来混合动力车的设计提供信息 斯佩尔克博士提出了一个指导性的研究计划，将估计 ZAPPS队列中重度孕产妇发病率的频率（目标1）;实施试点随机可行性 产后生理监测试验（目标2）;并评估采用数字化 通过实施研究框架，在资源有限的情况下进行卫生干预（目标3）。 这三个研究目标将为未来试验的设计提供初步数据。它们是相互关联的 研究结果将推动资源中的数字和产后健康研究- 不考虑结果的约束设置。这些研究中的每一项都与个性化的职业生涯相一致 临床试验设计和分析的发展目标，数字健康技术的实施研究， 和全球卫生研究合作伙伴关系。斯佩尔克博士召集了一个非常有成就的， 她的主要赞比亚导师Bellington Vwalika教授是一名专家， 在撒哈拉以南非洲的临床试验实施;她的主要美国导师，教授伊丽莎白斯特林格，专家 她的导师纪本智教授，是一位研究母胎医学及产妇健康流行病学的专家， 在撒哈拉以南非洲的实施科学。这三位导师都有数十年的合作经验， 全球卫生伙伴关系和指导早期职业研究人员的丰富经验。IRSDA将 推进斯佩尔克博士在这些领域的技能，支持教学和实践为基础的学习 机会，因为她建立了自己的独立调查领域和研究进展 全球产后健康独立。