The impact of COVID-19 pandemic-related stressors on childhood obesity and cardiometabolic risk

COVID-19 大流行相关压力源对儿童肥胖和心脏代谢风险的影响

• 批准号: 10706570
• 负责人: Alicia S Kunin-Batson
• 金额: $ 67.01万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-19 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10706570
• 关键词: 14 year old; 4 year old; Adult; Affect; African American; Age; Behavioral Mechanisms; Biological; Biological Markers; Body Composition; Body fat; Body mass index; Buffers; COVID-19; COVID-19 pandemic; COVID-19 pandemic effects; Cardiovascular system; Cell Aging; Child; Child Care; Child Health; Child Rearing; Childhood; Chronic; Clinical; Communities; Data; Data Collection; Development; Economics; Energy Intake; Enrollment; Ethnic Origin; Exhibits; Goals; Health; Health behavior; Heel; Hospitalization; Household; Hydrocortisone; Inadequate Sleep Hygiene; Income; Inflammation; Inflammatory; Intervention; Job loss; Latino; Longitudinal cohort; Low income; Measures; Mediating; Mental Health; Metabolic; Neighborhoods; Neurosecretory Systems; Obesity; Outcome; Overweight; Oxidative Stress; Parents; Pathway interactions; Physical activity; Policies; Population; Prevalence; Race; Recording of previous events; Reducing diet; Research; Resources; Risk; Security; Self Efficacy; Social Network; Social isolation; Stress; Surveys; Time; Weight maintenance regimen; Youth; biobehavior; cardiometabolic risk; cardiometabolism; cohort; effective intervention; ethnic diversity; executive function; experience; food insecurity; future outbreak; housing instability; imprint; obesity in children; obesity risk; obesity treatment; pandemic disease; pandemic impact; population health; prevent; prospective; protective factors; psychosocial stressors; public health priorities; racial diversity; resilience; response; risk mitigation; school disruption; stressor; trend; tv watching

Project Summary/Abstract The COVID-19 pandemic has had an alarming impact on already unacceptably high childhood obesity rates, and emerging evidence shows that traditional approaches to pediatric weight management have been markedly less effective since the onset of the pandemic. As obesity during childhood is much more likely to be sustained during adulthood, and children with obesity and other chronic conditions are more likely to have severe forms of COVID-19 requiring hospitalization, this alarming increase in childhood obesity rates is poised to have a broad and long-term impact on population health unless effective interventions are implemented. Yet, we know very little about the unique drivers of this dramatic increase in childhood obesity and whether BMI increases will persist and become lifelong. We know even less about the protective factors that mitigate this risk, as some youth will not develop obesity/worsening cardiometabolic health or may recover quickly despite risk exposures. Our goals are to uncover the biobehavioral pathways through which pandemic-related stressors drive childhood obesity and cardiometabolic risk, and to identify protective factors and intervention targets to mitigate the long-term impact of the pandemic on children’s health. The proposed research offers a unique, time-sensitive opportunity to prospectively examine the impact of multilevel stressors brought on by the pandemic to identify factors influencing BMI and cardiometabolic health trajectories. We will leverage an established longitudinal cohort of racially/ethnically diverse children (60% Latino) from predominantly low- income households, who were enrolled at 2-4 years of age (U01HD068890) and followed annually through ages 7-11 (R01HD090059). Underscoring the timeliness, uniqueness, and significance of this cohort, body composition, cardiovascular and metabolic functioning, neuroendocrine, oxidative stress, and inflammatory biomarkers, and health behaviors were obtained just prior to the onset of the pandemic (n=338). Drawing on a rich history of longitudinal data over 5 previous timepoints including immediately prior to the pandemic, we propose to add two new waves of data collection (7- and 8-years after inception of the cohort, 2-3 years post- onset of the pandemic) when children will be 10-14 years of age, an important developmental window of obesity and cardiometabolic imprinting. Multiple levels of pandemic-related stressors will be measured, alongside gold standard biological measures of stress activation, adiposity and cardiometabolic health, objective health behavior measures, and parent-child surveys. Our specific aims focus on identifying the pathways, parent-child factors, and neighborhood/community contexts needed to guide effective childhood obesity interventions in the aftermath of the pandemic and reduce adverse health consequences among vulnerable and understudied populations.

项目总结/摘要 2019冠状病毒病大流行对本已高得令人无法接受的儿童肥胖率产生了令人担忧的影响， 新出现的证据表明，传统的儿科体重管理方法 自大流行病爆发以来，效果明显下降。由于儿童时期的肥胖更有可能是 在成年期持续，肥胖和其他慢性疾病的儿童更有可能有 严重的COVID-19需要住院治疗，儿童肥胖率的惊人增长 除非采取有效的干预措施，否则，这将对人口健康产生广泛和长期的影响。然而， 我们对儿童肥胖症急剧增加的独特驱动因素知之甚少， 增长将持续下去，并成为终身。我们对减轻这种情况的保护因素所知更少 风险，因为一些年轻人不会发展肥胖/心脏代谢健康恶化，或者尽管 风险暴露。我们的目标是揭示生物行为途径，通过这些途径， 压力因素驱动儿童肥胖和心脏代谢风险，并确定保护因素和干预措施 目标是减轻这一流行病对儿童健康的长期影响。这项研究提供了一个 独特的，时间敏感的机会，前瞻性地检查多层次的压力源带来的影响， 大流行，以确定影响BMI和心脏代谢健康轨迹的因素。我们将利用 建立了种族/族裔多样化儿童（60%拉丁裔）的纵向队列，主要来自低收入家庭， 收入家庭，在2-4岁时入组（U 01 HD 068890），每年随访一次， 7-11岁（R 01 HD 090059）。强调这一群体的及时性、独特性和重要性， 组成、心血管和代谢功能、神经内分泌、氧化应激和炎症 生物标志物和健康行为在大流行开始之前获得（n=338）。借鉴一 在过去5个时间点（包括大流行之前）的纵向数据的丰富历史， 建议增加两波新的数据收集（队列开始后7年和8年， 这是一个重要的发展窗口期， 肥胖和心脏代谢印记。将测量与流行病相关的多个层面的压力源， 除了压力激活、肥胖和心脏代谢健康的黄金标准生物测量外， 客观的健康行为测量和亲子调查。我们的具体目标集中在确定 引导有效童年所需的途径、亲子因素和邻里/社区环境 在大流行病之后采取肥胖干预措施， 弱势和未被充分研究的人群。