TASK ORDER #3. NIMH. SYNTHESIS AND DISTRIBUTION OF DRUGS OF ABUSE AND RELATED COMPOUNDS.

承包商应经政府授权生产、分析真实性和纯度，并储存有标签和无标签的化合物(包括多肽)。承包商应接收、储存和维护来自NIMH化学合成和药物供应(CSDSP)库存(从合同HHSN271201400001l过渡)的化合物以及分析和技术信息。应通过承包商应维护的可公开访问的计划网站(https://nimh-repository.rti.org/).)向承包商提交清单中化合物的请求承包商应维护网站，提供以下信息：CSDSP的说明、NIMH清单中可用化合物的最新清单，以及提交化学合成或化合物申请的程序和表格。承包商应对库存化合物(有标签和无标签)的稳定性进行持续评估，并持续进行研发工作。经COR批准后，应在请求化合物时进行评价。纯度评估的必要性应基于自上次评估一种化合物以来的日期以及化合物在保持其最佳保质期条件下的已知稳定性。如果发生化学或放射化学变质，应进行再净化。承包商应使用新发现的或最新发现的对药物滥用研究有用的化合物以及该计划的任何新指南来识别、获取和更新药品供应库存(研究资源/目录)。

The Contractor shall produce, analyze for authenticity and purity, and store labeled and unlabeled chemical compounds (including peptides) upon government authorization. The Contractor shall receive, store, and maintain compounds, along with analytical and technical information, from the NIMH Chemical Synthesis and Drug Supply (CSDSP) inventory (to be transitioned from contract HHSN271201400001l). Requests for compounds in the inventory shall be submitted to the Contractor through the publicly accessible program website which shall be maintained by the Contractor (https://nimh-repository.rti.org/). The Contractor shall maintain the website with the following information: a description of the CSDSP, a up-to-date list of compounds available in the NIMH inventory, and procedures and forms for submitting requests for chemical synthesis or for compounds. The Contractor shall perform an on going evaluation of the stability of inventoried chemical compounds (labeled and unlabeled) and maintain research and development work continuously. The evaluation shall be conducted at the time a compound is requested, upon approval of the COR. The need for purity evaluation should be based on the date since the last assessment of a compound and the known stability of the compounds under the optimal shelf-life conditions in which they are maintained. Repurification shall be carried out if chemical or radiochemical deterioration occurs. The Contractor shall identify, acquire, and update the drug supply inventory (research resources/catalog) with new or latest discovered chemical compounds useful for drug abuse research and any new guidelines for the program.