K.C. Donnelly Externship - Promotion of Translational/Transdisciplinary Efforts in Graduate and Post-Doctoral Research

K.C.

基本信息

批准号：
10797644
负责人：
CHRISTY L HAYNES
金额：
$ 1.36万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2024-01-31
项目状态：
已结题

项目摘要

Project Description-(Abstract) Per-and polyfluoroalkyl substances (PFAS) are a serious concern due to extensive contamination in environment. As compared with other contaminants, PFAS are persistent, bioaccumulative and resistant to degradation. Therefore, effective clean-up of PFAS is urgently needed. Using plants to extract PFAS from soils through phytoremediation may be a practical approach. Our previous studies have investigated uptake of PFAS by hemp plants from soil, but this strategy is mostly limited to the removal of short-chain fluorinated molecules. Our existing R01 project investigates phytoremediation enhancement with novel materials such as ultra-mesoporous silica nanoparticles (UMNs) and carbon dots (CDs). Tuning the surface chemistry of these nanomaterials will enhance uptake of PFAS by plants and luminescent carbon dots will enable real time tracking of these materials in plants. Still, the disposal of PFAS contaminated biomass remains a challenge. Biodegradation of PFAS by microbes is a promising technology. It is a sustainable, green process that requires low capital and maintenance costs. Our preliminary studies achieved >70% degradation of perfluorooctanoic acid (PFOA) from PFAS contaminated hemp biomass following a reductive defluorination method using A6 microbes. Here, we propose to further investigate the microbial degradation of PFAS in contaminated hemp plants via a reductive defluorination method using a novel Acidimicrobiaceae sp. strain A6 and to assess the effect of nanomaterials on the PFAS degradation. 1

项目描述 - （摘要）由于环境中的广泛污染，每种和多氟烷基物质（PFA）是一个严重的问题。作为与其他污染物相比，PFA具有持久性，生物蓄积性和抗降解性。因此，有效迫切需要清理PFA。使用植物通过植物修复从土壤中提取PFA可能是一种实用方法。我们以前的研究调查了土壤中大麻植物对PFA的摄取，但该策略主要是仅限于去除短链氟化分子。我们现有的R01项目研究植物修复使用新型材料（例如超渗透二氧化硅纳米颗粒（UMN）和碳点（CDS））增强。调谐这些纳米材料的表面化学性质将增强植物和发光碳点对PFA的吸收在植物中实现这些材料的实时跟踪。尽管如此，处置PFA被污染的生物质仍然是一个挑战。微生物对PFA的生物降解是一项有前途的技术。这是一个可持续的绿色过程，需要低资本和维护成本。我们的初步研究实现了PFA的全氟辛酸（PFOA）降解> 70％使用A6微生物进行还原性脱氟化方法后，被污染的大麻生物量。在这里，我们建议进一步通过使用A的还原化流化方法研究PFA的微生物降解新颖的酸性细菌科Sp。应变A6并评估纳米材料对PFAS降解的影响。 1