Structural and functional understanding of bacterial defense and viral counter defense

项目摘要 感染细菌和古菌的病毒是地球上种类最多、数量最多的生物制剂。 这些无处不在的病毒捕食者施加的选择压力对 每种生态环境中微生物群落的组成和行为。为了击退这些病毒 捕食者、微生物进化出不同的防御机制来保护自己免受病毒感染。 尽管在这个仍处于萌芽状态的领域取得了快速进展，但在我们的基本认识上仍有许多盲点 细菌免疫学以及这些免疫系统与保存在真核生物中的免疫系统之间的关系。这个 这项补充的目的是募集资金，以更换我们目前的液相色谱系统。这个系统 现已停止服务。新的高效液相色谱系统将用于支持旨在使用 了解细菌免疫系统及其相互关系的生化和结构方法 真核生物的免疫系统。

Project Summary Viruses that infect bacteria and archaea are the most diverse and abundant biological agents on the planet. The selective pressures imposed by these ubiquitous viral predators has a profound impact on the composition and the behavior of microbial communities in every ecological setting. To fight off these viral predators, microbes have evolved diverse defense mechanisms to protect themselves from viral infections. Despite the rapid progress in this still nascent field, there are still many blind spots in our basic understanding of bacterial immunology and the relationship of these immune systems to those preserved in eukaryotes. The intent of this supplemental is to solicit funds to replace our current liquid chromatography system. This system is now out of service. The new liquid chromatography system will be used to support projects aimed at using biochemical and structural methods to understand bacterial immune systems and the relationship of these systems to the immune systems in eukaryotes.