Structural and functional understanding of bacterial defense and viral counter defense

项目摘要 感染细菌和古细菌的病毒是地球上最多样化和最丰富的生物制剂。 这些无处不在的病毒捕食者所施加的选择压力对人类产生了深远的影响。 微生物群落在每个生态环境中的组成和行为。为了击退这些病毒 作为捕食者，微生物已经进化出多种防御机制来保护自己免受病毒感染。 尽管在这一尚处于萌芽阶段的领域取得了迅速的进展，但在我们的基本认识上仍有许多盲点 以及这些免疫系统与真核生物中保存的免疫系统的关系。的 此补充的目的是募集资金，以取代我们目前的液相色谱系统。该系统 已经停止服务了新的液相色谱系统将用于支持旨在使用 生物化学和结构的方法来了解细菌免疫系统和这些之间的关系 真核生物的免疫系统。

Project Summary Viruses that infect bacteria and archaea are the most diverse and abundant biological agents on the planet. The selective pressures imposed by these ubiquitous viral predators has a profound impact on the composition and the behavior of microbial communities in every ecological setting. To fight off these viral predators, microbes have evolved diverse defense mechanisms to protect themselves from viral infections. Despite the rapid progress in this still nascent field, there are still many blind spots in our basic understanding of bacterial immunology and the relationship of these immune systems to those preserved in eukaryotes. The intent of this supplemental is to solicit funds to replace our current liquid chromatography system. This system is now out of service. The new liquid chromatography system will be used to support projects aimed at using biochemical and structural methods to understand bacterial immune systems and the relationship of these systems to the immune systems in eukaryotes.