Meaningful data integration, visualization and distribution for Human Pain Associated Genes & Cells Datasets

项目概要： PRECISION人类疼痛项目的主要目标是开发一个全面的分子数据集， 标志细胞类型和作为人类疼痛信号基础的细胞功能表型或标志 转导、传递和加工。为了最大限度地发挥通过这项工作产生的数据的影响， 对于标准化和整合U19中心生成的所有数据并使这些数据以 对更大的科学界有意义的方式。作为数据协调和集成中心，我们将 支持PRECISION Heal计划，以生成用于共享、可视化数据集的高影响力资源， 使这些数据集可用于下游分析和科学调查。在过去的七年里， 我们的跨学科团队开发了平台技术、标准和可视化机制， 在几个NIH项目的背景下查看生理数据（例如，REJOIN）。我们的合并域 专业知识涵盖了促进复杂数据集成的要求，特别是神经科学和 生理学数据集。我们将利用现有的平台技术和工作流程， HEAL PRECISION U19集中并领导开发知识和数据集成的工作 支持高影响力研究的能力。 我们将扩大我们的工作流程，与现有的HEAL数据生态系统紧密集成， 存储库以及各个U19数据核心的任何工作流和数据集成要求。在这 我们的目标是：（1）为HEAL Precision开发一个数据管理和知识平台 标准化整个HEAL Precision U19数据收集中心的数据集，提供以下手段 在数据发布之前，以有意义的方式在联合体之间共享数据，并整合知识 （2）开发新颖的可视化和数据探索机制， 这些数据作为集成数据生态系统的一部分。(3)为了增加治愈的影响力 PRECISION计划通过业务支持，推广和教育工作。该项目利用了 在生物信息学、生理学和医学领域的研究者之间建立了机构间合作， 知识管理，成功支持大型NIH数据资源工作的记录 管理

Project Summary: The PRECISION Human Pain project has a primary goal to develop a comprehensive datasets of molecular signature cell types, and cellular function phenotypes or signatures that underlie human pain signal transduction, transmission, and processing. To maximize the impact of the data generated through this effort, it is vital to standardize and integrate all data generated by the U19 centers and make these data available in a meaningful way to the larger scientific community. As the data coordination and integration center, we will support the PRECISION Heal initiative to generate a high impact resource for sharing, visualizing datasets, and making these datasets actionable for downstream analysis and scientific investigations. Over the last 7 years, our interdisciplinary team has developed platform technologies, standards, and visualization mechanisms to look at physiological data in context for several NIH programs (e.g. SPARC and REJOIN). Our combined domain expertise spans the requirements to facilitate complex data integration specifically for Neuroscience and physiology datasets. We will leverage our existing platform technologies and workflows to rapidly engage with the HEAL PRECISION U19 centers and lead the effort to develop the knowledge and data integration capabilities needed to support high impact research. We will expand our workflows to be tightly integrated with the existing HEAL Data Ecosystem, its repositories, and any workflow and data integration requirements by the individual U19 data cores. In this proposal our goals are: (1) To develop a data management and knowledge platform for HEAL Precision centers to standardize datasets across the HEAL Precision U19 data collection centers, provide the means to share data amongst the consortium in a meaningful way prior to data publication and integrate knowledge across all submitted data (2) To develop novel visualization and data exploration mechanisms to interact with these data in context as part of an integrated data ecosystem. (3) To increase the impact of the HEAL PRECISION program through operational support, outreach and educational efforts. This project leverages an established inter institutional collaboration between investigators across BioInformatics, Physiology and Knowledge Management with a track record of successfully supporting large NIH efforts with data resource management.