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Equipment Supplement- Prolonged duration and triggered local anesthesia

设备补充-延长持续时间并触发局部麻醉

基本信息

批准号：
10798980
负责人：
Daniel S Kohane
金额：
$ 15.86万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2025-04-30
项目状态：
未结题

项目摘要

Summary Many drug delivery systems for prolonged or triggerable local anesthesia are composed of polymers. Polymer molecular weight is a crucial parameter determining polymer function, as well as synthesis. Gel permeation chromatography is the gold standard way to determine molecular weight. GPC will allow us to determine exactly what the products of our syntheses are, whether these are polymers, block polymers, polymer-drug conjugates, polymer modification, and even nanoparticles. (All of these have been studied under the present R35.) GPC is also useful for chemical reaction monitoring in real time to determine whether we obtain the desired product for sustained and/or triggered release systems and to optimize the chemical synthesis routes. GPC is also the standard way to study polymer biodegradation – an important determinant of polymer function in vivo. GPC is a technique that we have frequently used in our research funded by NIGMS. Access to GPC has been a serious bottleneck to our research since there is only one at our institution and it is used for hydrophilic polymers only and is heavily oversubscribed. Using other institutions’ GPC is costly, time consuming (travel), suboptimal for sample stability, and impractical for real time reaction monitoring. We are therefore applying for an administrative supplement to purchase a GPC for our lab.

摘要许多用于延长或触发局部麻醉的药物输送系统由以下组成聚合物。聚合物相对分子质量是决定聚合物性能的关键参数，因为以及合成。凝胶渗透色谱是测定的金标准方法。分子量。GPC将使我们能够准确地确定我们合成的产品是，无论这些是聚合物，嵌段聚合物，聚合物-药物结合物，聚合物修饰，甚至是纳米颗粒。(所有这些都已在目前的R35下进行了研究。) GPC还可用于化学反应的实时监测，以确定我们是否获得了用于缓释和/或触发释放系统的所需产品，并优化化学品合成路线。凝胶渗透色谱也是研究聚合物生物降解的标准方法--一个重要的体内聚合物功能的决定因素。GPC是我们在我们的由NIGMS资助的研究。获取GPC一直是我们研究的一个严重瓶颈因为我们研究所只有一家，而且它只用于亲水性聚合物，而且是超额认购严重。使用其他机构的GPC既昂贵又耗时(旅行)，样品稳定性不佳，不适用于实时反应监测。我们是因此，申请行政补充，为我们的实验室购买GPC。