Equipment Supplement- Prolonged duration and triggered local anesthesia

总结 用于延长或可耐受的局部麻醉的许多药物递送系统由以下组成： 聚合物聚合物分子量是决定聚合物功能的关键参数， 以及合成。凝胶渗透色谱法是测定 分子量的GPC将使我们能够准确地确定我们的合成产物 无论是聚合物、嵌段聚合物、聚合物-药物缀合物、聚合物 修饰，甚至纳米颗粒。(All这些都是在目前的R35下进行研究的。 GPC还可用于真实的时间中的化学反应监测，以确定我们是否获得 用于持续和/或触发释放系统的所需产品，并优化化学品 合成路线GPC也是研究聚合物生物降解的标准方法-一种重要的生物降解方法。 体内聚合物功能的决定因素。GPC是一种我们经常使用的技术， 由NIGMS资助的研究。获得GPC一直是我们研究的严重瓶颈 因为在我们的机构只有一个，它只用于亲水聚合物， 严重超额认购使用其他机构的GPC是昂贵的，耗时（旅行）， 对于样品稳定性而言是次优的，并且对于真实的时间反应监测而言是不切实际的。我们 因此，申请行政补充，为我们的实验室购买GPC。

Summary Many drug delivery systems for prolonged or triggerable local anesthesia are composed of polymers. Polymer molecular weight is a crucial parameter determining polymer function, as well as synthesis. Gel permeation chromatography is the gold standard way to determine molecular weight. GPC will allow us to determine exactly what the products of our syntheses are, whether these are polymers, block polymers, polymer-drug conjugates, polymer modification, and even nanoparticles. (All of these have been studied under the present R35.) GPC is also useful for chemical reaction monitoring in real time to determine whether we obtain the desired product for sustained and/or triggered release systems and to optimize the chemical synthesis routes. GPC is also the standard way to study polymer biodegradation – an important determinant of polymer function in vivo. GPC is a technique that we have frequently used in our research funded by NIGMS. Access to GPC has been a serious bottleneck to our research since there is only one at our institution and it is used for hydrophilic polymers only and is heavily oversubscribed. Using other institutions’ GPC is costly, time consuming (travel), suboptimal for sample stability, and impractical for real time reaction monitoring. We are therefore applying for an administrative supplement to purchase a GPC for our lab.