SCH: A Novel Bias-mitigated Multimodal Oxygen Monitor

SCH：一种新型的消除偏差的多模式氧监测仪

• 批准号: 10816771
• 负责人: Ulkuhan Guler
• 金额: $ 28.51万
• 依托单位: WORCESTER POLYTECHNIC INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10816771
• 关键词: Admission activity; Adverse effects; Algorithms; Binding; Biomedical Research; Biosensing Techniques; Blood; Blood gas; COVID-19; Clinical; Collection; Custom; Data; Data Set; Diffusion; Ecosystem; Effectiveness; Electronics; Equity; Event; Female; Gases; Goals; Gold; Hemoglobin; Home; International; Journals; Justice; Knowledge; Life; Literature; Lung; Machine Learning; Measurement; Measures; Medical; Medicine; Methods; Miniaturization; Modality; Monitor; Neonatal Intensive Care Units; Outcome; Outpatients; Oxygen; Oxygen Therapy Care; Partial Pressure; Patients; Pigmentation physiologic function; Play; Process; PtcO2; Research; Research Personnel; Resolution; Resources; Respiratory Disease; Respiratory distress; Role; SMART health; Sensitivity and Specificity; Skin; Time; Transcutaneous Blood Gas Monitoring; Validation; Work; clinical practice; connected health; design; graduate student; improved; improved outcome; individualized medicine; infant monitoring; miniaturize; monitoring device; multimodality; neonate; novel; pandemic disease; people of color; racial bias; readmission risk; recruit; remote assessment; remote monitoring; remote patient monitoring; respiratory; sensor; sensor technology; signal processing; skin color; symposium; time use; treatment planning; undergraduate student; wearable device

Annually, ∼300,000 neonates are admitted to the neonatal intensive care unit (NICU) in the U.S., mostly due to respiratory distress. After a successful medical treatment in the NICU, earlier discharge to a stable home life could improve the chance of survival for neonates. However, the outpatient management of babies with fragile respiratory status is challenging in the absence of reliable remote monitoring devices suitable for use at home. Due to the small form factor and ease of use, contemporary home monitoring devices deploy sensors measuring SpO2, the saturation of hemoglobin bound to oxygen. Nevertheless, accurate assessment of oxygenation is complicated and not possible with only one parameter. Therefore, in clinical practice, invasive blood gas measurements - including partial pressure of oxygen (PaO2), which is the free dissolved oxygen (not bound to hemoglobin) - are not entirely replaced with SpO2. PaO2 is an essential cardio-respiratory measurement and the direct indication of lung effectiveness. A direct noninvasive method of assessing PaO2 is PtcO2, oxygen gas that diffuses through the skin. Creating an ability to sense two respiratory parameters (PtcO2 and SpO2) with one wearable is unique and superior to the current practice of measuring only SpO2, filling an important gap in miniaturization of the transcutaneous blood gas monitors.

在美国，每年有130万新生儿进入新生儿重症监护室（NICU），大多 因为呼吸困难在新生儿重症监护室成功治疗后， 家庭生活能提高新生儿的存活率。然而， 在没有可靠的远程监测设备的情况下，呼吸状态脆弱的婴儿是具有挑战性的 适合在家里使用。由于小巧的外形和易用性， 这些设备部署了测量SpO 2的传感器，SpO 2是与氧结合的血红蛋白的饱和度。然而，尽管如此， 氧合的准确评估是复杂的，并且仅用一个参数是不可能的。因此，我们认为， 在临床实践中，有创血气测量-包括氧分压（PaO 2）， 是游离溶解氧（不与血红蛋白结合）-不完全被SpO 2取代。PaO 2是一种 基本的心肺测量和肺有效性的直接指示。直接 评估PaO 2的非侵入性方法是PtcO 2，即通过皮肤扩散的氧气。创建 使用一个可穿戴设备感知两个呼吸参数（PtcO 2和SpO 2）的能力是独一无二的，并且优于上级 目前仅测量SpO 2的做法，填补了小型化的重要空白， 经皮血气监测仪