SCH: A Novel Bias-mitigated Multimodal Oxygen Monitor

在美国，每年有300,000名新生儿被送入新生儿重症监护病房(∼)，其中大部分 由于呼吸窘迫。在NICU成功治疗后，较早出院，情况稳定 家庭生活可以提高新生儿的存活机会。然而，门诊部的管理 在没有可靠的远程监护设备的情况下，患有脆弱呼吸状态的婴儿是具有挑战性的 适合在家里使用。由于外形小巧且易于使用，当代家庭监控 这些设备部署了测量SpO2的传感器，SpO2是与氧气结合的血红蛋白的饱和度。不过， 准确评估氧合作用是复杂的，仅有一个参数是不可能的。因此， 在临床实践中，有创血气测量-包括氧分压(PaO2)， 是游离的溶解氧(不与血红蛋白结合)--并不完全被SpO2取代。PaO2是一种 必要的心肺测量和肺功能的直接指示。一位直接的 评估PaO2的非侵入性方法是PTCO2，一种通过皮肤扩散的氧气。创建一个 在一台可穿戴设备上感知两个呼吸参数(PTCO2和SpO2)的能力是独一无二的，优于 目前仅测量血氧饱和度的做法填补了微型化的重要空白 经皮血气监测仪。

Annually, ∼300,000 neonates are admitted to the neonatal intensive care unit (NICU) in the U.S., mostly due to respiratory distress. After a successful medical treatment in the NICU, earlier discharge to a stable home life could improve the chance of survival for neonates. However, the outpatient management of babies with fragile respiratory status is challenging in the absence of reliable remote monitoring devices suitable for use at home. Due to the small form factor and ease of use, contemporary home monitoring devices deploy sensors measuring SpO2, the saturation of hemoglobin bound to oxygen. Nevertheless, accurate assessment of oxygenation is complicated and not possible with only one parameter. Therefore, in clinical practice, invasive blood gas measurements - including partial pressure of oxygen (PaO2), which is the free dissolved oxygen (not bound to hemoglobin) - are not entirely replaced with SpO2. PaO2 is an essential cardio-respiratory measurement and the direct indication of lung effectiveness. A direct noninvasive method of assessing PaO2 is PtcO2, oxygen gas that diffuses through the skin. Creating an ability to sense two respiratory parameters (PtcO2 and SpO2) with one wearable is unique and superior to the current practice of measuring only SpO2, filling an important gap in miniaturization of the transcutaneous blood gas monitors.