Using Patients' Stated Preferences to Inform and Support Proxy Decision-making during Palliative Treatment: Instrument Development and Evaluation
在姑息治疗期间利用患者陈述的偏好来告知和支持代理决策:仪器开发和评估
基本信息
- 批准号:10819002
- 负责人:
- 金额:$ 4.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAfrican AmericanAfrican American populationAnxietyAreaAwardCancer EtiologyCancer PatientCareer MobilityCessation of lifeClinicalClinical Cancer CenterCommunicationConflict (Psychology)Decision MakingDeteriorationDevelopmentDevice or Instrument DevelopmentDiagnosisDiseaseDisease ProgressionDocumentationEconomicsEnrollmentEquityEthnic PopulationEvaluationExclusionFaceFamilyFellowshipFoundationsFutureGoalsGuiltHealthInterventionInterviewK-Series Research Career ProgramsMalignant NeoplasmsMalignant neoplasm of prostateMeasuresMedical RecordsMental DepressionMentorshipMethodologyMinorityMinority GroupsModelingNational Cancer InstituteNeoplasmsOutcomeOutcome MeasureOutputPalliative CareParentsParticipantPartner CommunicationsPatient Outcomes AssessmentsPatient PreferencesPatient-Centered CarePatient-Focused OutcomesPatientsPerformancePolicy DevelopmentsPractice GuidelinesProcessProductivityProstateProviderProxyPublishingQualitative ResearchRecording of previous eventsRecurrenceReduce health disparitiesReportingResearchResearch Project GrantsResearch SupportResourcesRoleSamplingSolidSourceSpiritualityStressTechniquesTestingTrainingUncertaintyValidity and Reliabilityadvanced prostate canceranticancer treatmentcancer carecancer diagnosiscancer health disparitycancer therapyclinical careclinical practicedesigndisparity reductiondrug developmentempowermentexperienceexperimental studyimprovedinnovationinstrumentmenminority patientmortalitypalliativepatient engagementpatient orientedpreferencepreventprovider communicationracial populationrandomized trialrecruitstress reductionsupport toolstool
项目摘要
Project Summary
We will develop a discrete choice experiment (DCE) instrument to measure the trade-offs that advanced prostate
cancer patients make when deciding among palliative anti-cancer treatment options. Only one out of three
patients diagnosed with advanced prostate cancer is alive after five years. During disease progression, patient’s
capacity for treatment decision making often wanes and decision partners undertake increased treatment
decision making responsibility. This can result in elevated burden for decision partners, especially when there is
uncertainty regarding the patients’ treatment preferences. Our proposed DCE will be designed to elicit patient
treatment preferences to serve as a tangible guide to decision partners and the clinical team for future palliative
anti-cancer treatment decision making. Importantly, the development process will focus on the inclusion of
minority patients by oversampling African Americans and following models of decision making informed by
research with African American participants. In Aim 1, Q methodology and qualitative interview techniques will
be applied with patients and their decision partner to identify the important attributes of palliative anti-cancer
treatment options and explore decision partners role in decision making. In Aim 2, a DCE instrument will be
created and a subsequent sample of dyads (patient and decision partner) will be interviewed to engage patients
and their decision partner in instrument development and initial piloting for validity and reliability. We will
undertake a rigorous process to develop the DCE instrument following published best-practice guidelines. The
output of this research project will include a DCE instrument to quantify patient’s palliative anti-cancer treatment
preferences. This project will impact clinical practice by providing an objective measure of patients’ palliative
anti-cancer treatment preferences to decision partners and the clinical team that can help guide treatment
decisions. Future research will investigate the potential role of DCEs in decision support. This award will support
the research, training, and professional development necessary for the Applicant to transition into a career
advancing decision support research to mitigate health disparities and reduce negative outcomes for patients
and their decision partners, including stress, anxiety, guilt, and depression. Upon completion of this Fellowship,
the Applicant will have a solid foundation for future research to investigate decision support, beginning with a
career development award to test the developed DCE instrument in larger samples to derive generalizable
results. This application is aligned with the National Cancer Institute Scientific Priority Area of preventing,
understanding, and mitigating cancer health disparities due to our unique focus on inclusive sampling. The
Applicant is well supported to accomplish this goal with a Sponsor and Cosponsor who have a long history of
working together productively in the area of cancer health disparities, and collaborators with expertise in the
scientific areas relevant to the proposed research.
项目摘要
我们将开发一种离散选择实验(DCE)仪器来测量前列腺增生的利弊,
癌症患者在决定姑息性抗癌治疗方案时所做的决定。只有三分之一
诊断为晚期前列腺癌的患者在五年后仍然存活。在疾病进展期间,患者的
治疗决策能力往往减弱,决策伙伴承担更多治疗
决策责任。这可能会增加决策伙伴的负担,特别是在有
患者治疗偏好的不确定性。我们提出的DCE旨在引起患者
治疗偏好作为决策伙伴和临床团队未来姑息治疗的有形指南
抗癌治疗决策。重要的是,发展进程将侧重于纳入
少数民族患者通过对非洲裔美国人进行过度抽样,并遵循由
与非裔美国人的研究。在目标1中,Q方法和定性访谈技术将
应用于患者及其决策伙伴,以确定姑息性抗癌的重要属性
治疗方案,并探讨决策伙伴在决策中的作用。在目标2中,一种DCE仪器将
创建一个样本,随后将对二人组(患者和决策伙伴)进行访谈,以吸引患者参与
和他们的决策伙伴在仪器开发和初步试点的有效性和可靠性。我们将
按照已公布的最佳做法准则,开展严格的程序,制定数据交换和环境监测工具。的
该研究项目的成果将包括一个DCE仪器,以量化患者的姑息性抗癌治疗
喜好该项目将通过提供患者姑息治疗的客观措施来影响临床实践。
抗癌治疗偏好的决策伙伴和临床团队,可以帮助指导治疗
决策未来的研究将探讨DCE在决策支持中的潜在作用。该奖项将支持
申请人过渡到职业生涯所需的研究,培训和专业发展
推进决策支持研究,以减轻健康差距,减少患者的负面结果
和他们的决策伙伴,包括压力,焦虑,内疚和抑郁。完成本奖学金后,
申请人将为未来研究决策支持打下坚实的基础,
职业发展奖,在更大的样本中测试开发的DCE工具,以得出可推广的
结果该应用程序与国家癌症研究所的预防科学优先领域保持一致,
了解和减轻癌症健康差异,因为我们独特的重点是包容性抽样。的
申请人得到很好的支持,以实现这一目标的赞助商和共同赞助商谁有悠久的历史,
在癌症健康差异领域富有成效地合作,并与在
与拟议研究相关的科学领域。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Winter Maxwell Thayer其他文献
Effects of deworming on child and maternal health: a literature review and meta-analysis
- DOI:
10.1186/s12889-017-4747-0 - 发表时间:
2017-11-01 - 期刊:
- 影响因子:3.600
- 作者:
Winter Maxwell Thayer;Adrienne Clermont;Neff Walker - 通讯作者:
Neff Walker
Using Latent Class Analysis to Model Preference Heterogeneity in Health: A Systematic Review
- DOI:
10.1007/s40273-017-0575-4 - 发表时间:
2017-10-03 - 期刊:
- 影响因子:4.600
- 作者:
Mo Zhou;Winter Maxwell Thayer;John F. P. Bridges - 通讯作者:
John F. P. Bridges
Winter Maxwell Thayer的其他文献
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{{ truncateString('Winter Maxwell Thayer', 18)}}的其他基金
Using Patients' Stated Preferences to Inform and Support Proxy Decision-making during Palliative Treatment: Instrument Development and Evaluation
在姑息治疗期间利用患者陈述的偏好来告知和支持代理决策:仪器开发和评估
- 批准号:
10469320 - 财政年份:2021
- 资助金额:
$ 4.42万 - 项目类别:
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